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Terfenadine (Seldane)

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A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

Also Known As:

Seldane; Aliud Brand of Terfenadine; Balkis Saft Spezial; Bial Brand of Terfenadine; Cantabria Brand of Terfenadine; Cyater; Dolorgiet Brand of Terfenadine; Heumann Brand of Terfenadine; Hisfedin; Hoechst Brand of Terfenadine; Merck dura Brand of Terfenadine; Mundipharma Brand of Terfenadine; RMI-9918; Rapidal; Sigma-Tau Brand of Terfenadine; Stadapharm Brand of Terfenadine; Teldane; Terfedura; Terfemundin; Terfenadin AL; Terfenadin Heumann; Terfenadin Stada; Terfenadin-ratiopharm; Terfenidine; Ternadin; Triludan; Wolff Brand of Terfenadine; alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol; ct-Arzneimittel Brand of Terfenadine; ratiopharm Brand of Terfenadine; terfenadin von ct; RMI 9918; RMI9918; Sigma Tau Brand of Terfenadine; ct Arzneimittel Brand of Terfenadine; 1-Piperidinebutanol, alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-

Networked: 430 relevant articles (69 outcomes, 111 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Dao Wen: 3 articles (01/2013 - 06/2009)
2.	Asumendi, Aintzane: 3 articles (12/2011 - 09/2006)
3.	Jangi, Shawkat-Muhialdin: 3 articles (12/2011 - 09/2006)
4.	Nicolau-Galmés, Francesca: 3 articles (12/2011 - 03/2008)
5.	Boyano, María D: 3 articles (12/2011 - 03/2008)
6.	Pérez-Yarza, Gorka: 3 articles (12/2011 - 09/2006)
7.	Fish, Jeffrey M: 3 articles (03/2006 - 01/2003)
8.	Antzelevitch, Charles: 3 articles (03/2006 - 01/2003)
9.	Chen, Chen: 2 articles (01/2013 - 06/2009)
10.	Arroyo-Berdugo, Yoana: 2 articles (12/2011 - 03/2008)

Related Diseases

1.	Seasonal Allergic Rhinitis (Hay Fever) 01/01/1984 - "Eighty patients with hay fever took part in a double-blind study to compare the efficacy of two doses of terfenadine, namely 60 mg b.d., the standard recommended dose, and 120 mg b.d. " 12/01/1989 - "Terfenadine, 120 mg once daily, is as effective as the currently approved dosage of 60 mg twice daily in the treatment of seasonal allergic rhinitis, and terfenadine, 120 mg once daily, has the added convenience of allowing the patient once a day dosing." 10/27/1988 - "The cumulative results indicate that the nonsedative antihistamine terfenadine, given orally at a dosage of 60 mg twice daily, is effective in the treatment of seasonal allergic rhinitis in both adults and children. " 04/01/1988 - "It is concluded that terfenadine is a safe and effective non-sedating antihistamine in the maintenance therapy of seasonal allergic pollinosis and that tolerance is not noted during continued administration." 09/01/1990 - "terfenadine, given to avoid withdrawals from the trial because of hay fever symptoms. "
2.	Rhinitis 01/01/1982 - "No attacks of allergic rhinitis were seen due to the potent prophylactic efficacy of terfenadine. " 01/01/1990 - "Overall, terfenadine improved all rhinitis symptoms except those related to hypersecretion. " 07/01/1987 - "For some patients, terfenadine, in the currently recommended dose of 60 mg twice daily (bid), may be only modestly effective in the treatment of allergic rhinitis. " 09/01/1995 - "The aim of the present study (placebo-controlled, double-blind, randomized) was the evaluation of the antiallergic activity of Terfenadine in the model of the allergic rhinitis due to natural pollen exposure. " 12/01/1988 - "This double-blind, randomized multicentre study was designed to compare efficacy and tolerability of 120 mg terfenadine taken once daily (in the morning) with the established regimen of 60 mg terfenadine taken twice daily in the treatment of seasonal rhinitis. "
3.	Urticaria (Hives) 12/01/1985 - "Terfenadine, a potent and non-sedative antihistamine, was shown to be effective in chronic idiopathic urticaria in a double-blind crossover placebo controlled trial. " 03/01/1988 - "Terfenadine is a useful therapeutic agent for primary management of chronic idiopathic urticaria." 09/01/1989 - "The objective of these three double-blind multi-centre studies was to determine whether terfenadine 120 mg once daily has similar efficacy and tolerability as the standard dosage of 60 mg twice daily in the treatment of chronic urticaria. " 08/01/1987 - "A double-blind placebo controlled study of terfenadine in the treatment of chronic idiopathic urticaria." 04/01/1993 - "Treatment of solar urticaria with terfenadine."
4.	Sneezing 09/01/1989 - "Both treatments were effective in reducing symptom scores but BDP was significantly better than terfenadine in relieving running nose and sneezing (P less than 0.05). " 09/01/2001 - "Only terfenadine (10 mg/kg) significantly inhibited sneezing at any challenge time. " 05/01/1996 - "During the pollen season (March-April), the patients who took the active treatment reported less sneezing and rhinorrhea than the placebo group, on the basis of a symptoms score, and the differences were statistically significant; the need for drugs (terfenadine) was also significantly reduced. " 01/01/1988 - "The results showed a significant inhibitory effect of terfenadine on secretion and sneezing, but no significant difference between treatments with regard to blockage. " 12/01/1991 - "Evaluations by both subjects and physicians suggest that terfenadine at 120 mg given twice daily marginally improved sneezing and total symptom scores at day 4. When comparing terfenadine to placebo, neither the symptoms nor signs of the common cold improved in a clinically or statistically significant manner. "
5.	Perennial Allergic Rhinitis 03/01/1991 - "In a double-blind, parallel-group study to compare the efficacy of 120 mg terfenadine taken orally once daily with that of the conventional regimen of 60 mg terfenadine taken twice daily, 30 patients with perennial allergic rhinitis were enrolled. " 08/20/2010 - "Bepotastine 20 mg/day was significantly more effective than terfenadine 120 mg/day in patients with perennial allergic rhinitis, as evaluated by the final global improvement rating and several other endpoints in a phase III trial. " 03/01/1991 - "The results indicate that the new once-daily regimen of terfenadine was as effective and as well tolerated as the twice-daily regimen for the treatment of perennial allergic rhinitis." 03/01/1991 - "Comparison of terfenadine once daily with terfenadine twice daily for the treatment of perennial allergic rhinitis." 08/01/1993 - "The efficacy of loratadine and terfenadine in perennial allergic rhinitis was evaluated in a double-blind, selected cross-over study consisting of two phases. "

Related Drugs and Biologics

1.	Cetirizine (Zyrtec)
2.	Loratadine (Alavert)
3.	Astemizole
4.	Chlorpheniramine (Chlorphenamine)
5.	Clemastine (Clemastine Fumarate)
6.	Terfenadine (Seldane)
7.	Histamine Antagonists (Antihistamines)
8.	Histamine (Histamine Dihydrochloride)
9.	Budesonide (Pulmicort)
10.	Tablets

Related Therapies and Procedures

1.	Immunotherapy
2.	Premedication
3.	Vagus Nerve Stimulation
4.	Self Medication
5.	Injections