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Fleroxacin

A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.

Also Known As:

AM-833; Grünenthal Brand of Fleroxacin; Quinodis; Ro 23-6240; AM 833; AM833; Ro 23 6240; Ro 236240; 3-Quinolinecarboxylic acid, 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

Networked: 151 relevant articles (36 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinolines: 92
    - Quinolones: 1190
      - Fluoroquinolones: 2005
        Ciprofloxacin: 4530
        Fleroxacin: 151
        Ro-23-9424: 5
        fleroxacin N-oxide: 1
        N-demethylfleroxacin
        Ro 19-7728

Experts

1.	Mutua, Florence M: 1 article (01/2012)
2.	Wiysonge, Charles Shey: 1 article (01/2012)
3.	M'imunya, James Machoki: 1 article (01/2012)
4.	Nishihata, Masaya: 1 article (12/2009)
5.	Ebisuno, Shoichi: 1 article (12/2009)
6.	Hara, Isao: 1 article (12/2009)
7.	Nishikawa, Toru: 1 article (12/2009)
8.	Kohjimoto, Yasuo: 1 article (12/2009)
9.	Goto, Koichi: 1 article (07/2005)
10.	Furuhama, Kazuhisa: 1 article (07/2005)

Related Diseases

1.	Infection 06/01/1986 - "The excellent therapeutic efficacy of AM-833 against these systemic and local infections may be a result of its good oral absorption and high levels in tissues." 03/22/1993 - "Concentrations of fleroxacin in human body fluids and tissues were studied to obtain information about the efficacy of the drug at the site of infection and the ratio of fleroxacin concentrations in tissue or fluid versus those in plasma as a measure of the extent of penetration. " 03/22/1993 - "Efficacy of oral fleroxacin in bone and joint infections." 03/22/1993 - "A total of 20 (91%) of the fleroxacin-treated patients and 29 (88%) of the AMX/CP-treated patients were bacteriologically cured (two fleroxacin- and one AMX/CP-treated patients developed super-infection). " 05/01/1995 - "Fleroxacin 400mg once daily also achieved bacteriological cure in approximately 80% of patients with bone and joint infections in preliminary studies. "
2.	Urinary Tract Infections (Urinary Tract Infection) 07/01/1998 - "Therefore, it may be expected that half of the dose of fleroxacin gives comparable results in the treatment of urinary tract infections; this should be substantiated in comparative clinical trials." 09/01/1995 - "A sequential study of intravenous and oral Fleroxacin for 7 or 14 days in the treatment of complicated urinary tract infections." 10/01/1993 - "In comparison of participant and reference laboratory zone diameters, absolute qualitative agreement was 88.7% for the approved NCCLS interpretive criteria and 94.8% for the criteria used in the fleroxacin urinary tract infection clinical trials. " 03/22/1993 - "This study enrolled patients with complicated urinary tract infections (UTIs) in a trial to determine the efficacy and safety of sequential therapy with intravenous fleroxacin (first 3 days) followed by oral fleroxacin, for a total course of 7-14 days, both administered at a dosage of 400 mg once a day. " 03/22/1993 - "A sequential study of intravenous and oral fleroxacin in the treatment of complicated urinary tract infection."
3.	Chancroid 05/01/1992 - "Fleroxacin, as a single oral dose, is an effective treatment for culture-proven chancroid in patients who are HIV-1 seronegative. " 05/01/1989 - "We performed an initial randomized clinical trial to assess the efficacy of fleroxacin for treatment of chancroid in Nairobi, Kenya. " 03/22/1993 - "Fleroxacin was prescribed to treat both HIV-negative and HIV-positive men with proven chancroid in an open study. " 03/22/1993 - "Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1." 03/22/1993 - "Fleroxacin is an acceptable alternative to existing treatment regimens for chancroid in men."
4.	Endocarditis 04/01/1989 - "Efficacy of fleroxacin in experimental methicillin-resistant Staphylococcus aureus endocarditis." 04/01/1989 - "The efficacy of fleroxacin versus that of vancomycin was assessed by using the rabbit model of methicillin-resistant Staphylococcus aureus endocarditis. " 08/01/1991 - "Development of resistance to fleroxacin during therapy of experimental methicillin-susceptible Staphylococcus aureus endocarditis." 08/01/1991 - "The efficacy of fleroxacin was compared with that of vancomycin by using the rabbit model of methicillin-susceptible Staphylococcus aureus endocarditis. " 03/01/2000 - "Efficacy of amikacin, ofloxacin, pefloxacin, ciprofloxacin, enoxacin and fleroxacin in experimental left-sided Pseudomonas aeruginosa endocarditis."
5.	Diarrhea 03/22/1993 - "This study was designed to test the efficacy of 400 mg fleroxacin given orally as a single dose or once daily for 3 days against acute bacterial diarrhea. " 03/22/1993 - "Treatment of acute bacterial diarrhea: a multicenter international trial comparing placebo with fleroxacin given as a single dose or once daily for 3 days." 03/22/1993 - "In The Gambia, 195 tourists with acute diarrhea were randomized in a double-blind, controlled trial into three treatment groups: fleroxacin 400 mg for 1 day, fleroxacin 400 mg daily for 2 days, and placebo. " 03/22/1993 - "The good overall clinical and bacteriologic responses of most patients with acute bacterial diarrhea of fleroxacin indicate that this convenient single-dose therapy should be advantageous for empiric treatment of certain diarrheal illnesses." 03/22/1993 - "Patients treated with fleroxacin, both single-dose and 3-day regimens, showed faster clinical improvement than did placebo-treated patients, as shown by earlier cessation of diarrhea (p < 0.001) and reduction in mean number of loose stools per day on days 2, 3, and 5 after start of therapy (p < 0.05). "

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Ofloxacin (Levofloxacin)
3.	Norfloxacin
4.	Vancomycin
5.	Pefloxacin
6.	Rifampin (Rifampicin)
7.	Ceftriaxone (Ceftriaxon)
8.	Cefotaxime (Kendrick)
9.	Azithromycin (Zithromax)
10.	Amoxicillin (Wymox)

Related Therapies and Procedures

1.	Catheters
2.	Transurethral Resection of Prostate (TURP)
3.	Oral Administration
4.	Intravenous Injections
5.	Intraperitoneal Injections