Hidradenitis

The inflammation of a sweat gland (usually of the apocrine type). The condition can be idiopathic or occur as a result of or in association with another underlying condition. Neutrophilic eccrine hidradenitis is a relatively rare variant that has been reported in patients undergoing chemotherapy, usually for non-Hodgkin lymphomas or leukemic conditions.

Also Known As:

Networked: 106 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hidradenitis Suppurativa
2.	Infection
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4.	Skin Diseases
5.	Neoplasms (Cancer)

Experts

1.	García-Diez, A: 2 articles (12/2014 - 06/2007)
2.	Larson, Allison R: 1 article (12/2015)
3.	Laga, Alvaro C: 1 article (12/2015)
4.	Granter, Scott R: 1 article (12/2015)
5.	Miller, Iben M: 1 article (09/2015)
6.	Fraga, J: 1 article (12/2014)
7.	Sánchez-Pérez, J: 1 article (12/2014)
8.	García-Martín, P: 1 article (12/2014)
9.	Golshan, Mehra: 1 article (11/2014)
10.	Giess, Catherine S: 1 article (11/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hidradenitis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 10/01/2001 - "All patients had long-standing hidradenitis (mean 12 years), and had been treated with several courses of antibiotics. " 01/01/1954 - "[Roentgenotherapy of hidradenitis after discovery of antibiotics]." 04/01/2011 - "His diagnosis changed along the years and has been treated with antibiotics many times to control pustule formation and hidrosadenitis, which evolved to keloidal scars, requiring neck zethaplasty due to limitation of mobility. " 12/01/1998 - "Antibiotics are often used to treat hidradenitis, but only topical clindamycin has been shown to be effective in a randomized controlled trial. " 04/01/2009 - "Etanercept was generally well tolerated; however, two patients discontinued the study as a result of skin infections at the site of hidradenitis lesions requiring oral antibiotics. "
2.	Clindamycin (Cleocin)FDA LinkGeneric 06/01/1983 - "Thirty patients with recurrent suppurative hidradenitis entered a double blind trial to evaluate the effect of topical clindamycin against placebo in hidradenitis. " 12/01/1998 - "Antibiotics are often used to treat hidradenitis, but only topical clindamycin has been shown to be effective in a randomized controlled trial. " 04/01/2011 - "Rifampicin and clindamycin for hidradenitis."
3.	TNFR-Fc fusion protein (etanercept)FDA Link 04/01/2009 - "Our study demonstrated minimal evidence of clinically significant efficacy of etanercept (50 mg/wk subcutaneously) in the treatment of hidradenitis. " 04/01/2009 - "Etanercept was generally well tolerated; however, two patients discontinued the study as a result of skin infections at the site of hidradenitis lesions requiring oral antibiotics. "
4.	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 12/01/1985 - "In response to a combined thyrotrophin releasing hormone and gonadotrophin releasing hormone test, the prolactin and TSH responses were significantly greater in the hidradenitis patients than the controls. "
5.	ProlactinIBA 12/01/1985 - "In response to a combined thyrotrophin releasing hormone and gonadotrophin releasing hormone test, the prolactin and TSH responses were significantly greater in the hidradenitis patients than the controls. "
6.	HormonesIBA 12/01/1985 - "In response to a combined thyrotrophin releasing hormone and gonadotrophin releasing hormone test, the prolactin and TSH responses were significantly greater in the hidradenitis patients than the controls. "
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/01/2009 - "Randomized, controlled trials will be necessary to demonstrate the risk-to-benefit ratio of tumor necrosis factor-alpha inhibitors in the treatment of hidradenitis." 05/01/2012 - "The descriptions of neutrophilic eccrine hidradenitis-like and Sweet's-like hypersensitivity eruptions induced by anti-TNF-alpha therapies are the first such cases described in the literature. "
8.	Cytarabine (Cytosar-U)FDA LinkGeneric 01/01/2012 - "Neutrophilic eccrine hidradenitis induced by cytarabine." 02/01/2013 - "Part III: Neutrophilic eccrine hidradenitis in the setting of acute myelogenous leukemia treated with cytarabine." 07/01/1986 - "These findings are characteristic of neutrophilic eccrine hidradenitis, which, to our knowledge, has previously been reported only in patients with acute myelogenous leukemia who were receiving cytarabine chemotherapy. " 10/01/1984 - "Neutrophilic eccrine hidradenitis: a distinctive rash associated with cytarabine therapy and acute leukemia." 01/01/2011 - "Neutrophilic eccrine hidradenitis (NEH) was originally described as a distinctive dermatosis occurring in patients undergoing chemotherapy, especially associated with the use of cytarabine in the treatment of acute myelogenous leukemia (AML). "
9.	Isotretinoin (Accutane)FDA LinkGeneric 01/01/1988 - "A review of the literature indicates that the results of treatment with isotretinoin for hidradenitis have been at best equivocal. " 10/22/1983 - "56 patients with nodulocystic acne, hidrosadenitis (2 cases) and steatocystoma multiplex (2 cases) were treated with oral isotretinoin. " 04/01/1982 - "Good to excellent clinical results have been obtained in the treatment of severe inflammatory acne (acne conglobata, acne fulminans, and acne conglobata with hidradenitis and dissecting cellulitis of the scalp) with orally administered isotretinoin (13-cis-retinoic acid). "
10.	infliximab (Remicade)FDA Link 02/01/2008 - "Ten patients with severe, recalcitrant hidradenitis were treated with infliximab (three infusions of 5 mg kg(-1) at weeks 0, 2 and 6) and followed up for at least 1 year. " 06/01/2007 - "Treatment of hidradenitis supurativa with infliximab constitutes a moderately useful alternative in some cases." 12/01/2007 - "Infliximab dramatically and favorably impacted on three cases of hidradenitis, but also in one of the patients who also had pyoderma gangrenosum. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 11/01/2011 - "Neutrophilic eccrine hidradenitis (NEH) presents as tender erythematous papules and plaques and is often associated with chemotherapy for AML. " 11/01/2011 - "Eccrine hidradenitis sine neutrophils: a toxic response to chemotherapy." 06/01/2005 - "Neutrophilic eccrine hidradenitis (NEH) is occasionally reported in patients who have not received chemotherapy. " 05/01/2003 - "We describe a neutrophilic eccrine hidradenitis case unassociated with chemotherapy in a woman with chronic myelogenous leukaemia." 05/01/2003 - "Neutrophilic eccrine hidradenitis was initially described in acute myelogenous leukaemic patients undergoing chemotherapy, suggesting a drug-induced mechanism. "
2.	X-Ray Therapy 06/22/1963 - "[Roentgenotherapy in axillary hidrosadenitis]." 09/01/1961 - "[Roentgenotherapy of hidrosadenitis axillaris]." 10/01/1956 - "[Roentgenotherapy of hidradenitis]." 02/01/1984 - "The antiinflammatory roentgenotherapy was used in 150 patients with pyo-inflammatory processes (post-operative inflammatory complications, periappendicular infiltration, hydradenitis, osteo-articular panaritium, mastitis). " 01/01/1954 - "[Roentgenotherapy of hidradenitis after discovery of antibiotics]."
3.	Gas Lasers 02/01/1991 - "Over the past eight years we treated 11 patients who had extensive, chronic hidradenitis of the anogenital area with the CO2 laser. "
4.	Body Piercing (Piercing, Body) 11/01/2014 - "Known risk factors included lactational (4), recurrent subareolar abscess (4), diabetes (3), hydradenitis suppuritiva (1), nipple piercing (2), smoking (1), pregnancy (1), HIV (1), and lumpectomy (1). "
5.	Transplants (Transplant) 01/01/2004 - "The method of closure with a combination of skin flaps and skin graft in one stage can be considered a valid surgical option for a group of patients with extensive perianal hidradenitis."