Cyclosporine (Ciclosporin)

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).

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Networked: 13440 relevant articles (1432 outcomes, 1363 trials/studies)

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Drug Context: Research Results

Experts

1.	Ovize, Michel: 19 articles (09/2015 - 02/2005)
2.	Yang, Chul Woo: 19 articles (01/2013 - 06/2002)
3.	Young, Neal S: 17 articles (05/2015 - 03/2003)
4.	Nakao, Shinji: 14 articles (01/2012 - 10/2002)
5.	Storb, Rainer: 14 articles (10/2010 - 03/2002)
6.	Atilla, Gül: 13 articles (09/2015 - 04/2003)
7.	Yoshikawa, Norishige: 13 articles (02/2014 - 05/2002)
8.	Li, Can: 13 articles (08/2008 - 06/2002)
9.	Lim, Sun Woo: 12 articles (01/2013 - 12/2002)
10.	Kami, Masahiro: 12 articles (10/2007 - 11/2002)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 09/20/1992 - "Several controlled clinical studies have shown that cyclosporin is highly effective in controlling severe psoriasis. " 06/01/2003 - "Cyclosporin is known to be highly effective in the treatment of psoriasis in adults. " 01/01/2001 - "Cyclosporine is highly effective and well tolerated in the short term treatment of severe psoriasis." 11/29/1997 - "New therapies aimed at reducing T cell activity are most successful, as exemplified by the efficacy of systemic cyclosporine in severe cases of psoriasis. " 06/01/1996 - "Cyclosporine has proved to be highly effective in the treatment of psoriasis. "
2.	Nephrotic Syndrome (Syndrome, Nephrotic) 01/01/1990 - "Results of the available literature and preliminary data of an ongoing multicenter, prospective, randomized Italian trial indicate that ciclosporin (CS), at low doses, may maintain remission of the nephrotic syndrome in most steroid-sensitive patients. " 07/01/2013 - "However, the addition of cyclosporine A finally resulted in complete remission of the nephrotic syndrome. " 06/01/2012 - "Complete remission of his nephrotic syndrome was achieved after 1 year of cyclosporine and corticosteroid therapy. " 04/01/2011 - "All patients showed complete or partial remission of nephrotic syndrome with cyclosporin A and preserved stable renal function over a follow-up period of 5 years. " 11/01/2004 - "Cyclosporine has also been shown to be effective in inducing a partial or the complete remission of nephrotic syndrome. "
3.	Ulcerative Colitis 03/01/2010 - "Cyclosporin A (CSA), an immunosuppressive agent, is highly efficacious in patients with refractory ulcerative colitis (UC). " 10/01/2003 - "Cyclosporine A is highly effective in severe attacks of ulcerative colitis (UC) but is associated with important adverse effects that are mainly dose dependent. " 01/01/2012 - "Ciclosporin has proven to be effective in patients with corticosteroid-refractory ulcerative colitis (UC). " 11/01/2008 - "Cyclosporine A (CsA) has been found to be the first successful therapy used in the recovery of patients with steroid-refractory ulcerative colitis (UC). " 09/04/1998 - "Our data confirm the efficacy of intravenous cyclosporine as a rapid acting drug for severe ulcerative colitis. "
4.	Atopic Dermatitis (Atopic Eczema) 12/01/1992 - "In previous studies, oral cyclosporine was highly effective in the treatment of patients with severe atopic dermatitis. " 09/01/2007 - "Although cyclosporin A treatment is highly efficacious and relatively safe, we report four adult atopic dermatitis (AD) patients who deteriorated during long-term cyclosporin A treatment, with clinical signs and symptoms more severe than at the onset of treatment. " 01/01/2000 - "Cyclosporin (CyA) has been shown to be highly effective and well tolerated in the short-term treatment of severe childhood atopic dermatitis; however, there is limited experience in its longer-term use. " 01/01/1999 - "Cyclosporin A (CsA) has been shown to be highly effective in the therapy of atopic dermatitis (AD). " 04/01/2002 - "During the last decade, oral cyclosporin (CsA) has proven to be effective, in randomized controlled trials, for the treatment of atopic dermatitis (AD) in human patients. "
5.	Graft vs Host Disease (Graft-Versus-Host Disease) 05/01/1985 - "Withdrawal of cyclosporin A, which is highly effective in preventing graft-versus-host disease, can be fatal. " 07/17/1982 - "Oral cyclosporin A is extremely effective at reducing the severity of graft-versus-host disease, but prevention of the disease is limited by toxicity of the drug and variable absorption. " 09/01/2013 - "The safety and efficacy of acute graft-versus-host disease prophylaxis with a higher target blood concentration of cyclosporine around 500 ng/mL." 12/01/2009 - "After a minimum of a 2-month course of treatment with more frequent dosing of cyclosporine 0.05% (3 times a day in 7 patients and 4 times a day in 15 patients), overall dry eye symptoms were improved in 15 (68.2%) patients (9 patients with ocular graft-versus-host disease and 6 patients with Sjögren's syndrome). " 11/01/1996 - "Signs and symptoms of ulcerative oral graft-versus-host-disease improved more than 50% in three of four patients with oral graft-versus-host disease treated with the addition of topical cyclosporine. "

Related Drugs and Biologics

1.	Tacrolimus (Prograf)
2.	Methotrexate (Mexate)
3.	Cyclosporine (Ciclosporin)
4.	Adrenal Cortex Hormones (Corticosteroids)
5.	Azathioprine (Imuran)
6.	Prednisolone (Predate)
7.	Cyclophosphamide (Cytoxan)
8.	Steroids
9.	mycophenolate mofetil (Cellcept)
10.	Antilymphocyte Serum (Anti-Thymocyte Globulin)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Homologous Transplantation (Allograft)
4.	Kidney Transplantation
5.	Colectomy