HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Amyloid beta-Protein Precursor (Amyloid Protein Precursor)

Subscribe to New Research on Amyloid beta-Protein Precursor

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Also Known As:

Amyloid Protein Precursor; Amyloid beta Precursor Protein; Protease Nexin 2; Protease Nexin II; Amyloid beta Protein Precursor; Nexin 2, Protease; Nexin II, Protease; beta Amyloid Protein Precursor; beta-Protein Precursor, Amyloid; Amyloid A4 Protein Precursor; beta-Amyloid Protein Precursor

Networked: 416 relevant articles (1 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	D'Adamio, Luciano: 9 articles (01/2010 - 02/2002)
2.	Smith, Mark A: 7 articles (01/2010 - 09/2002)
3.	Perry, George: 7 articles (01/2010 - 09/2002)
4.	Wolfe, Michael S: 7 articles (07/2008 - 08/2002)
5.	Lahiri, Debomoy K: 6 articles (02/2010 - 10/2002)
6.	Small, David H: 6 articles (01/2010 - 01/2002)
7.	Bredesen, Dale E: 4 articles (06/2015 - 11/2003)
8.	Lannfelt, Lars: 4 articles (05/2015 - 02/2008)
9.	Golde, Todd E: 4 articles (05/2010 - 04/2002)
10.	Zhu, Xiongwei: 4 articles (01/2010 - 09/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 07/01/1995 - "A marked and significant reduction of protease nexin-1 (PN-1) and PN-2/amyloid beta protein precursor (A beta PP) was observed in selected regions of Alzheimer's disease (AD) brains as compared to those of aged-matched controls. " 01/01/2010 - "Since hyper-homocysteinemia (HHcy) was recognized as a risk factor for Alzheimer's disease (AD), many studies tried to induce HHcy in animal models to investigate its effect on amyloid-beta protein precursor (AbetaPP) metabolism. " 03/01/2007 - "This study analyzed whether platelet amyloid beta-protein precursor (AbetaPP) isoform ratio correlates with cognition or cognitive decline in patients with Alzheimer's disease (AD). " 05/01/1993 - "Studies comparing the expression of the amyloid beta protein precursor (APP) gene in brains of patients with Alzheimer's disease (AD) and control individuals have resulted in contradictory findings indicative of selective reductions and relative increases of APP alternative transcripts in AD brain. " 01/01/1991 - "Studies of amyloid beta-protein precursor expression in Alzheimer's disease."
2.	Amyloidosis 08/01/2001 - "APPsw transgenic mice (Tg2576) overproducing mutant amyloid beta protein precursor (betaAPP) show substantial brain Abeta amyloidosis and behavioural abnormalities. " 01/01/2000 - "Common treatments of amyloidoses are based on decreasing the availability of the amyloid protein precursor. " 06/01/1991 - "Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease." 06/01/1990 - "Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)." 10/13/2000 - "Impaired neurotransmitter systems by Abeta amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor."
3.	Neuroblastoma 01/01/2011 - "All four compounds protected MC65 neuroblastoma cells from amyloid beta protein precursor C-terminal fragment (APP CTF)-induced neurotoxicity. " 06/01/2008 - "Exogenous CoQ protected MC65 neuroblastoma cells from amyloid-beta protein precursor C-terminal fragment (APP CTF)-induced neurotoxicity in a concentration dependent manner, with concentrations of 6.25 microM and higher providing near complete protection. " 10/01/1996 - "We have established a stably transformed human neuroblastoma cell line (MC65) that conditionally expresses a C-terminal derivative of the amyloid beta protein precursor (beta PP) termed S beta C (a fusion protein composed of the amino-17 and carboxyl-99 residues of beta PP). " 01/01/1994 - "The toxic effect of Alzheimer amyloid protein precursor overexpressed in the neuroblastoma cell line NB-1 on neurite outgrowth." 01/01/2009 - "In this study, we found that the production of amyloid-beta (Abeta) was reduced by FLZ in Abeta-expressing neuroblastoma cells, and correlated with an increase in the soluble alpha-secretase derived fragment of the amyloid-beta protein precursor (sAbetaPPalpha) in the medium. "
4.	Autolysis 04/01/2001 - "The objective of the study was to explain the effect of autolysis on immunohistochemical detection of neurone-specific enolase (NSE), beta-amyloid protein precursor (beta-APP) and ubiquitine in cerebral tissue. " 09/01/2006 - "Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?"
5.	Pheochromocytoma 12/01/2008 - "Rat pheochromocytoma PC12 cells transfected with amyloid beta precursor protein bearing Swedish double mutation (APPsw) and control PC12 cells transfected with empty vector were used in this study. "

Related Drugs and Biologics

1.	Amyloid (Amyloid Fibrils)
2.	Proteins (Proteins, Gene)
3.	Amyloid Precursor Protein Secretases (beta-Secretase)
4.	Presenilins
5.	Amyloid beta-Peptides
6.	Messenger RNA (mRNA)
7.	Protease Inhibitors (Protease Inhibitor)
8.	Codon (Codons)
9.	Phosphopyruvate Hydratase (Enolase)
10.	Copper

Related Therapies and Procedures

1.	Denervation