A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
Also Known As:
Amyloid Protein Precursor; Amyloid beta Precursor Protein; Protease Nexin 2; Protease Nexin II; Amyloid beta Protein Precursor; Nexin 2, Protease; Nexin II, Protease; beta Amyloid Protein Precursor; beta-Protein Precursor, Amyloid; Amyloid A4 Protein Precursor; beta-Amyloid Protein Precursor