Tacrolimus (Prograf)

A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.

Also Known As:

Prograf; Anhydrous Tacrolimus; FK-506; FK506; FR-900506; Prograft; Tacrolimus Anhydrous; Anhydrous, Tacrolimus; FK 506; FR 900506; FR900506; Tacrolimus, Anhydrous; 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-

Networked: 7819 relevant articles (1154 outcomes, 1103 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Antin, Joseph H: 26 articles (12/2022 - 09/2003)
2.	Soiffer, Robert J: 18 articles (12/2022 - 09/2003)
3.	Champlin, Richard E: 17 articles (12/2021 - 11/2003)
4.	Reitamo, Sakari: 17 articles (08/2014 - 01/2002)
5.	Ruzicka, T: 17 articles (12/2009 - 01/2000)
6.	Alyea, Edwin P: 16 articles (12/2022 - 09/2003)
7.	Cutler, Corey: 16 articles (12/2022 - 09/2003)
8.	Ho, Vincent T: 16 articles (12/2022 - 09/2003)
9.	Koreth, John: 16 articles (12/2022 - 07/2007)
10.	Hesselink, Dennis A: 16 articles (10/2022 - 08/2010)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 07/01/2008 - "The proportion of dendritic cell subpopulations in the skin is important for the severity of atopic dermatitis because topical treatment with tacrolimus leads to rapid depletion of inflammatory dendritic epidermal cells, whereas Langerhans cells (LCs) predominate in cured sites. " 05/01/2002 - " accumulated evidence of the various publications seems to indicate that tacrolimus is a safe and effective treatment of atopic dermatitis in patients aged 2 years or more. " 10/01/2018 - "Therefore, we aimed to fabricate polymeric nanoparticles (NPs) to deliver tacrolimus (TCS) to deeper layers of the skin in order to alleviate its systemic toxicity and improved therapeutic efficacy against atopic dermatitis (AD). " 11/01/2006 - "Topical tacrolimus represents an effective and well-tolerated treatment for atopic dermatitis (AD). " 11/01/2003 - "Topical tacrolimus has recently been found to be an effective treatment for atopic dermatitis (AD). "
2.	Vitiligo 07/01/2021 - "Topical Tacrolimus, especially when combined with Nb-UVB, has been proven clinically to be effective in the treatment of vitiligo. " 01/01/2022 - "Our findings suggest that both treatments are safe and the combination of tacrolimus and 308-nm EL is more effective than 308-nm EL alone for periocular vitiligo." 05/01/2011 - "Topical tacrolimus is more effective for treatment of vitiligo in patients of skin of color." 11/01/2021 - "Topical tacrolimus is effective in vitiligo treatment with minimal effect on extra-facial lesions. " 10/01/2013 - "Combination of narrow-band ultraviolet B and topical tacrolimus is effective for segmental vitiligo."
3.	Ulcerative Colitis 08/01/2019 - "Tacrolimus is very effective at inducing remission in patients with refractory ulcerative colitis. " 07/01/2018 - "Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus." 04/05/2021 - "Nevertheless, for refractory cases such as that of our patient, for whom even this regimen is inefficacious, tacrolimus might be recommended to induce remission as with cases of ulcerative colitis." 01/01/2021 - "Tacrolimus (Tac) is an effective remission inducer of refractory ulcerative colitis (UC). " 10/01/2019 - "Tacrolimus is effective for refractory ulcerative colitis in adults, while data for children is sparse. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 09/01/2005 - "Proven efficacy of tacrolimus for facial and intertriginous psoriasis." 04/01/1996 - "At the end of week 9, tacrolimus+-treated patients had a significantly greater reduction in the Psoriasis Area and Severity Index than did placebo-treated patients (tacrolimus, -83; placebo, -47; P<.02). " 09/01/2020 - "The present study was undertaken to investigate the systemic immunomodulatory and therapeutic efficacy effects of MDSC plus FK-506 in an IMQ-induced mouse model of psoriasis and to investigate the immunomodulatory mechanisms involved. " 01/01/2016 - "Topical tacrolimus is particularly effective for inverse psoriasis, which is likely to be due to the reduced level of induration seen in these psoriatic lesions, which allows greater skin penetrance, compared with hyperkeratotic plaques of psoriasis on the body. " 02/01/2011 - "Tacrolimus is effective in treatment of psoriasis vulgaris. "
5.	Proteinuria 01/01/2012 - "The efficacy and safety of tacrolimus in such refractory IgAN patients are extremely ambiguous, and the mechanism of tacrolimus improving proteinuria remission needs to be investigated. " 04/01/2002 - "After tacrolimus discontinuation, 13/17 patients (76%) relapsed and were treated with a second trial of tacrolimus for 1 year, achieving complete remission in five patients (38.4%), partial remission in four patients (30.7%) and reduction of proteinuria <3 g/day in four patients (30.7%). " 10/01/2006 - "A significant improvement in proteinuria levels was observed in the tacrolimus group compared with the control group, starting at the second week and remaining throughout the study period. " 01/01/2012 - "Tacrolimus showed a rapid proteinuria remission in refractory IgAN patients. " 03/01/2010 - "The decrease of proteinuria was significantly greater in tacrolimus group. "

Related Drugs and Biologics

1.	Ointments (Pastes)
2.	Cyclosporine (Ciclosporin)
3.	Steroids
4.	Tacrolimus (Prograf)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	Immunosuppressive Agents (Immunosuppressants)
7.	Mycophenolic Acid (Cellcept)
8.	Calcineurin Inhibitors
9.	Cyclophosphamide (Cytoxan)
10.	Prednisolone (Predate)

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Transplantation
4.	Kidney Transplantation
5.	Cell Transplantation

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