Choroid Plexus Neoplasms (Choroid Plexus Tumor)

Benign or malignant tumors which arise from the choroid plexus of the ventricles of the brain. Papillomas (see PAPILLOMA, CHOROID PLEXUS) and carcinomas are the most common histologic subtypes, and tend to seed throughout the ventricular and subarachnoid spaces. Clinical features include headaches, ataxia and alterations of consciousness, primarily resulting from associated HYDROCEPHALUS. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072; J Neurosurg 1998 Mar;88(3):521-8)

Also Known As:

Networked: 129 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Glioma (Gliomas)
2.	Meningioma (Meningiomas)
3.	Neoplasms (Cancer)
4.	Carcinoma (Carcinomatosis)
5.	Choroid Plexus Papilloma

Experts

1.	Hasselblatt, Martin: 9 articles (05/2020 - 01/2006)
2.	Paulus, Werner: 6 articles (07/2016 - 01/2006)
3.	Thomas, Christian: 5 articles (05/2020 - 03/2016)
4.	Jeibmann, Astrid: 5 articles (12/2009 - 01/2006)
5.	Malkin, David: 4 articles (01/2019 - 06/2012)
6.	Beschorner, Rudi: 4 articles (03/2016 - 07/2006)
7.	Wolff, Johannes E A: 4 articles (03/2010 - 01/2009)
8.	Wrede, Brigitte: 4 articles (12/2009 - 12/2007)
9.	Kutluk, Tezer: 3 articles (02/2022 - 01/2009)
10.	Dhall, Girish: 3 articles (05/2020 - 06/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Choroid Plexus Neoplasms:

1.	Proteins (Proteins, Gene)FDA Link 07/01/2020 - "FGFR3 and FGFR1 proteins are expressed in a subpopulation of choroid plexus tumors. " 01/01/2002 - "Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children." 07/01/2020 - "The aim of this study was to uncover the expression of FGFR1 and FGFR3 proteins in choroid plexus tumors and to further characterize FGFR-related as well as other genetic alterations in FGFR3 expressing tumors. " 03/01/2016 - "Notable SPDEF protein expression was encountered in 15/19 PTPRs as compared with only 2/36 ependymal tumors, 2/19 choroid plexus tumors and 0/23 samples of other central nervous system (CNS) tumor entities. " 01/01/2017 - "Relative to normal brain tissues, uPAR protein and mRNA expression were significantly greater in canine meningiomas, gliomas, and choroid plexus tumors. "
2.	Messenger RNA (mRNA)IBA 01/01/2017 - "Relative to normal brain tissues, uPAR protein and mRNA expression were significantly greater in canine meningiomas, gliomas, and choroid plexus tumors. "
3.	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 10/01/2017 - "The aim of this study was to review and describe therapeutic approaches in children with choroid plexus tumor (CPT) based on a nationwide series. " 02/01/2011 - "The purpose of this study is to evaluate the results of microsurgical treatment for choroid plexus tumors (CPT) in adult patients. " 02/01/2023 - "There are limited data available on incidence and survival of patients with choroid plexus tumors (CPT). " 01/01/2023 - "Choroid plexus tumors (CPT) are believed to originate from outgrowths of the choroid plexus. " 01/01/2021 - "A diagnosis of spinal choroid plexus tumor (CPT) and intervertebral disc extrusion was made. "
4.	cytidylyl-(3'-5')-cytidine (CpC)IBA 01/01/2020 - "CPC is the most aggressive choroid plexus tumor. " 04/01/2019 - "The description of the presentation and progression of these rare adult-onset CPC provides insight for the diagnosis and treatment of other rare instances of choroid plexus tumors." 12/01/2017 - "A comprehensive search of the PubMed and Google Scholar databases was performed using the following MeSH terms to find all possible reports on CPC: choroid plexus tumor; choroid plexus carcinoma; choroid plexus carcinoma AND treatment; and choroid plexus carcinoma AND survival. " 09/01/1991 - "This limits the usefulness of TTR immunohistochemistry in the diagnosis of primary choroid plexus neoplasms and in the distinction of CPC from metastatic carcinoma." 05/01/2020 - "DNA methylation profiling segregates choroid plexus tumors into three distinct epigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP), infratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial pediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). "
5.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/01/2022 - "This case report serves to broaden knowledge of disseminated CPP and to encourage complete neuro-axis imaging for choroid plexus tumors. " 05/01/2012 - "Cystic choroid plexus tumor is a rare variant of choroid plexus papilloma (CPP), reported mostly in infants. " 02/01/2001 - "A group of choroid plexus tumors fit the cellular criteria for choroid plexus papilloma (CPP) except for invasion into the adjacent parenchyma, with associated loss of the normal villus architecture at the site of invasion. " 05/01/2020 - "DNA methylation profiling segregates choroid plexus tumors into three distinct epigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP), infratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial pediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). " 01/01/2013 - "Overall, 168 pediatric subjects with choroid plexus tumors were identified as follows: 75 cases of CPP, 12 cases of atypical CPP and 81 cases of CPC. "
6.	Tumor Viral Antigens (Large T Antigen)IBA 09/01/2004 - "SV11 mice are immunocompetent, yet immunologically tolerant to large T antigen expressed by choroid plexus tumors. " 11/09/1998 - "SV11 mice transgenic for SV40 large T antigen and its promoter develop solid choroid plexus tumors in the brain. " 04/01/1994 - "While loss of the p53-binding region results in loss of the capacity to induce lymphoid abnormalities, dl1137 retains the ability to induce choroid plexus tumors that are histologically indistinguishable from those induced by wild-type T antigen. " 06/01/1992 - "The results presented here show that binding of T antigen to p53 is not required for induction of choroid plexus tumors. " 02/01/1992 - "Like the wild-type SV40 transgenic mice, mice with the JCV T antigen under the control of the SV40 enhancer and promoter developed choroid plexus tumors and renal pathology. "
7.	Folic Acid (Vitamin M)FDA LinkGeneric 04/01/1997 - "We report that SV11 choroid plexus tumors contain a high affinity folate receptor (KD of 1 nM), detectable by 125I-folate autoradiography and immunohistochemistry. " 04/01/1997 - "Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice." 04/01/1997 - "A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. " 09/01/2004 - "The high affinity folate receptor is expressed on endogenously arising choroid plexus tumors of SV11 mice, which are transgenic for large T antigen under the control of the SV40 promoter. " 11/09/1998 - "We demonstrate that choroid plexus tumor cells are susceptible in vitro to cytolysis mediated by cytotoxic T cells in the presence of the bispecific ligand-antibody conjugate in a folate-inhibitable manner. "
8.	Monoclonal AntibodiesIBA 11/01/1996 - "We studied 10 choroid plexus tumors (four papillomas and six carcinomas) by immunohistochemistry using the DO7 anti-p53 monoclonal antibody. " 11/09/1998 - "The bispecific ligand-antibody conjugate described in this study is a chemical conjugate between an anti-CD3 monoclonal antibody (MAb) and folic acid, the ligand for a high-affinity surface receptor expressed on the surface of choroid plexus tumors. " 04/01/1988 - "Twenty-six ependymal and 15 choroid plexus tumors were examined with monoclonal antibody against cytokeratin using the avidin-biotin-peroxidase complex (ABC) technique. " 06/01/1987 - "Sixteen choroid plexus tumors (CPTs) have been investigated for the localization of different immunocytochemical markers of epithelial and nonepithelial nature, namely, simple epithelial-type cytokeratins, vimentin, glial fibrillary acidic protein (GFAP), a panepithelial antigen defined by the lu-5 monoclonal antibody (lu-5 antigen), S-100 protein, and epithelial membrane antigen (EMA). "
9.	LectinsIBA 01/01/1993 - "Lectin histochemistry might be useful for the differential diagnosis of primary choroid plexus neoplasms and other brain tumors such as secondary carcinoma." 01/01/1991 - "Lectin histochemistry of the normal and neoplastic human choroid plexus cells [six choroid plexus papillomas (CPPs) and three choroid plexus carcinomas (CPCs)] was performed using eight representative lectins to study the development of sugar chain structures and also to determine whether lectins were useful for a histopathological diagnosis of choroid plexus neoplasms (CPNs). "
10.	Proliferating Cell Nuclear Antigen (PCNA)IBA 11/01/1996 - "Clinicopathological study of choroid plexus tumors: immunohistochemical features and evaluation of proliferative potential by PCNA and Ki-67 immunostaining." 07/01/2010 - "We retrospectively reviewed the clinicopathologic and histological features in 37 patients with choroid plexus tumors and correlated these with glial fibrillary acidic protein (GFAP) expression and proliferation cell nuclear antigen (PCNA), p53, p21, and Rb labeling indexes, with special attention to tumor recurrence/regrowth. "

Therapies and Procedures

1.	Preoperative Care 11/01/2012 - "Embolization of choroid plexus tumors via anterior choroidal artery is potentially dangerous, but following a meticulous technique, it can be used as a safe and effective preoperative procedure."
2.	Therapeutics 11/01/2019 - "These findings may serve at determining new strategies to distinguish the types of choroid plexus tumor, and at developing novel targeted therapies. " 01/01/2019 - "These models will be valuable tools for understanding the biology of choroid plexus tumors and for testing novel approaches to therapy. " 04/01/2008 - "Adjuvant therapy for choroid plexus tumors with brain stem infiltration must be established." 10/01/2009 - "In conclusion, our findings suggest that PDGF receptor beta is functionally involved in the biology of choroid plexus tumors and may represent a molecular target for therapy. " 07/01/2001 - "These preliminary results, if confirmed in a larger cohort of patients, indicate that proton MRS may have a role in the presurgical diagnosis of choroid plexus tumors in children, which may also have important implications for therapy and prognosis."
3.	Radiotherapy 10/31/1989 - "The role of radiotherapy in the management of choroid plexus neoplasms." 01/01/1977 - "Preoperative radiotherapy as well as shunt operations and tentorial section can be considered as first stage procedures for the surgical management of choroid plexus neoplasms in certain cases." 01/01/1985 - "This chemotherapy regimen should be considered for future trials in patients with choroid plexus tumors and recurrence after surgery and/or radiotherapy." 01/01/2022 - "Case Report: Ventriculoperitoneal Shunting and Radiation Therapy Treatment in a Cat With a Suspected Choroid Plexus Tumor and Hypertensive Hydrocephalus."
4.	Drug Therapy (Chemotherapy) 01/01/1985 - "This chemotherapy regimen should be considered for future trials in patients with choroid plexus tumors and recurrence after surgery and/or radiotherapy." 12/01/2007 - "Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors." 02/01/2022 - "Standards for chemotherapy against choroid plexus tumors (CPT) have not yet been established. "
5.	Cardiopulmonary Resuscitation (CPR) 11/01/1997 - "Others showed previously that expression of a mutant large T antigen containing the N-terminal 121 amino acids (T1-121) under control of the lymphotropic papovavirus promoter resulted in slow-growing choroid plexus tumors, whereas full-length T antigen under the same promoter induced rapidly growing CPR tumors, T-cell lymphomas, and B-cell lymphomas. "