Bronchial Hyperreactivity

Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.

Also Known As:

Networked: 1109 relevant articles (57 outcomes, 125 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Asthma (Bronchial Asthma)
2.	Inflammation (Inflammations)
3.	Airway Remodeling
4.	Rhinitis
5.	Eosinophilia

Experts

1.	Hammad, Hamida: 7 articles (01/2022 - 04/2011)
2.	Kuna, Piotr: 7 articles (01/2022 - 01/2002)
3.	Habre, Walid: 7 articles (08/2014 - 07/2006)
4.	Lambrecht, Bart N: 6 articles (01/2022 - 04/2011)
5.	Ciprandi, Giorgio: 6 articles (11/2014 - 02/2006)
6.	Groeben, H: 6 articles (01/2014 - 01/2000)
7.	Kline, Joel N: 6 articles (03/2009 - 05/2002)
8.	Stelmach, Iwona: 6 articles (01/2003 - 01/2002)
9.	Helyes, Zsuzsanna: 5 articles (06/2020 - 05/2007)
10.	Kereskai, László: 5 articles (06/2020 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bronchial Hyperreactivity:

1.	Histamine (Histamine Dihydrochloride)FDA Link 06/01/2004 - "In conclusion, ECT induced a significantly greater bronchial reaction in patients with AA and bronchial hyperreactivity to histamine than in patients with AR and bronchial normoreactivity to histamine and controls. " 03/01/2003 - "Histamine provocations were performed at the age of 7 years in the MAS cohort to determine bronchial hyperreactivity; in the Freiburg study population a standardized exercise-induced decrease in FEV1 was evaluated. " 12/01/1994 - "Therefore, the objective of the present study was to assess the bronchopulmonary effects in asthmatic patients who showed a moderate to severe bronchial hyperreactivity towards histamine (PC20 FEV1 < or = 1 mg/ml). " 04/01/1986 - "Bronchial provocation studies with histamine demonstrated significant bronchial hyperreactivity in 0.5% (1 in 195) rural and 1.7% (1 in 59) urban children, rates which were significantly lower than those observed in corresponding adult populations (7%). " 11/01/2005 - "Saturation with histamine abrogated the inhibitory effect of EV131 on bronchial hyperreactivity. "
2.	Methacholine Chloride (Methacholine)FDA Link 07/01/1993 - "The results show in both groups a mild but statistically not significant reduction of the provocation reaction in the inhalative methacholine provocation test in the sense of an improvement in bronchial hyperreactivity. " 02/15/2005 - "Histopathological examination revealed Pw immunization reduced the severity of airway pathology and decreased bronchial hyperreactivity to methacholine exposure. " 07/01/1997 - "Although this study disclosed no acute or delayed asthmatic symptoms or deterioration of pulmonary function detected by using conventional spirometry, methacholine inhalation before and after cow milk challenge may be more sensitive for evaluation of cow milk-induced bronchial hyperreactivity." 12/01/1996 - "During this study, 553 randomly selected and 204 symptomatic participants aged between 20 and 44 years completed a detailed respiratory questionnaire, of whom 675 underwent measurement of bronchial hyperreactivity (BHR) by methacholine challenge and 745 had skin prick tests for atopy. " 11/01/1994 - "All patients showed bronchial hyperreactivity to inhaled methacholine before the study. "
3.	AllergensIBA 01/01/2003 - "Patients in Group A showed a significant improvement (p < 0.05) in specific bronchial hyperreactivity, and at the end of the study needed 5.5 times more native unmodified allergen to obtain the same degree of bronchial response as in the beginning. " 02/01/1998 - "Encasings for mattresses, blankets and pillows in combination with mite allergen reduction on the floor have proved effective in reducing bronchial hyperreactivity of mite-allergic children. " 01/01/1991 - "The results of this study demonstrate the importance of duration, character and concentration of allergen exposition on formation of specific bronchial hyperreactivity. " 03/01/1985 - "Although SCG has a mediator-inhibiting effect, this study gave no support for the assumption that inhibition of mediator release leads to a reduction of the bronchial hyperreactivity in atopic asthmatic subjects who are not exposed to relevant allergens." 10/01/2017 - "Different clinical effect of several types of airborne allergens on the severity of bronchial hyperreactivity."
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2019 - "We are uncertain whether inhaled corticosteroids result in an improvement in exercise tolerance, bronchial hyperreactivity or exacerbations as the quality of the evidence was very low. " 02/01/2002 - "We concluded that, in determining discontinuation of inhaled corticosteroid prophylaxis, duration of clinical remission seems to be a more useful criterion than measurement of UEPX levels, lung function test, and assessment of bronchial hyperreactivity." 07/01/1998 - "Several trials have found that late use of inhaled corticosteroids is associated with a smaller effect on bronchial hyperreactivity and lung function compared with early use. " 07/01/2015 - "Members of this phylum are associated with disease features such as bronchial hyperreactivity or corticosteroid resistance. " 02/01/2005 - "For reducers, smaller improvements occurred for night use of rescue beta2-agonists, doses of inhaled corticosteroids, and bronchial hyperreactivity. "
5.	Immunoglobulin E (IgE)IBA 01/01/2019 - "However, specific IgE levels were significantly reduced and bronchial hyperreactivity significantly improved in sensitized mice treated with olive pollen and bacterial derivatives (MPL or ISSs)." 03/01/2005 - "SLIT seems to be effective in ameliorating clinical symptoms, drug consumption and bronchial hyperreactivity, and results in downregulation of Der-p-1-specific IgE production. " 03/01/2018 - "This study suggests that IgE may play a role in bronchial hyperreactivity associated to A. fumigatus exposure in mice. " 03/01/2018 - "In this study, we demonstrated that exposure of sensitized mice to a known concentration of A. fumigatus conidia produces bronchial hyperreactivity with marked neutrophilic bronchial infiltration and increased BALF IgE, capable of triggering mast cell degranulation. " 03/01/2000 - "On the basis of studies with animal models, the gene for the low-affinity receptor for immunoglobulin E (IgE) (FCER2, CD23) has been implicated as a candidate for IgE-mediated allergic diseases and bronchial hyperreactivity, or related traits. "
6.	Albuterol (Salbutamol)FDA LinkGeneric 06/01/1994 - "None of the subjects in the control group improved their baseline FEV1/VC% to salbutamol, but three showed bronchial hyperreactivity similar to those in group A. " 09/01/2006 - "The continued use of racemic albuterol, which contains a mixture of R-albuterol and S-albuterol, has been questioned because of data from preclinical and clinical studies suggesting that S-albuterol causes proinflammatory effects and may increase bronchial hyperreactivity. " 10/01/1997 - "Further dose ranging studies are required at steady state to evaluate the pharmacokinetics of R- and S-salbutamol and their relative effects on bronchial hyperreactivity when given on a regular basis to asthmatic subjects." 12/01/1994 - "Moreover, it had to be established to what extent the bronchial responsiveness to inhaled salbutamol was retained and whether pulmonary effects were related to the severity of bronchial hyperreactivity. " 05/01/1994 - "Albuterol causes a major reduction in the bronchial hyperreactivity in young wheezy children shortly after administration."
7.	Beclomethasone (Beclometasone)FDA Link 01/01/1991 - "A statistically significant reduction in bronchial hyperreactivity (PC20-FEV1, 5.49 +/- 1.86 mg/mL) but no systemic side effects were observed after 2 months of treatment with beclomethasone dipropionate. " 06/01/1992 - "Dissociation of symptom scores and bronchial hyperreactivity: study in asthmatic children on long-term treatment with inhaled beclomethasone dipropionate." 01/01/1982 - "The effect of beclomethasone diproprionate on bronchial hyperreactivity." 05/27/1991 - "[Effect of inhalation therapy with beclomethasone dipropionate on unspecific bronchial hyperreactivity in patients with asthma]." 01/01/1989 - "The results of the present study show that maintenance treatment with inhaled beclomethasone combined with salbutamol may lead to greater improvement in bronchial hyperreactivity than treatment with inhaled beclomethasone dipropionate alone."
8.	Bronchodilator Agents (Bronchodilators)IBA 10/19/2005 - "Compared to placebo, short-acting beta-2 agonists increased forced expiratory volume at one second (FEV(1)) in the short term in three out of five trials, and in the long-term increased peak expiratory flow rate in individuals who had been shown to have bronchial hyperreactivity or bronchodilator responsiveness or both. " 12/01/2022 - "A pharmacological inhalation test with a bronchodilator that acts on β2-adrenergic receptors of the lungs was used to detect early changes in the ventilatory capacity of the lungs - bronchial hyperreactivity. " 06/01/2009 - "The response to bronchodilators in adults is not predictive of bronchial-hyperreactivity." 06/01/2008 - "Response to bronchodilators after exercise challenge predicts bronchial hyperreactivity." 04/01/2008 - "The present investigation was undertaken to evaluate the bronchodilator and bronchial hyperreactivity of the stem bark of Myrica sapida. "
9.	Budesonide (Pulmicort)FDA LinkGeneric 08/01/2012 - "Both TRP and budesonide significantly ameliorated functional and histological OVA-induced bronchial hyperreactivity. " 08/01/1991 - "We conclude that for a better assessment of the treatment of bronchial hyperreactivity with budesonide, the drug must be administered for a longer period of time. " 01/01/1988 - "In a double-blind study of 2 parallel groups of 15 allergic asthmatic patients each, we investigated whether treatment with inhaled budesonide has a dose- and time-dependent effect on the degree of bronchial hyperreactivity. " 01/01/1988 - "Dosage and time effects of inhaled budesonide on bronchial hyperreactivity." 06/07/1986 - "Budesonide seems to influence and mitigate bronchial hyperreactivity in the responder group."
10.	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/01/2014 - "Symptoms and PEF were monitored daily; exhaled nitric oxide (eNO) and spirometry every four weeks; sputum eosinophil (sEo) and bronchial hyperreactivity (BHR) assessed at the beginning and at the end of the study. " 11/01/2013 - "The aim of this study was to analyze the relationship among BMI, spirometry, bronchial hyperreactivity (BHR), and fractional concentration of exhaled nitric oxide (FeNO) in a cohort of AR patients. " 11/01/2013 - "The aim of this study was to analyze the relationship among BMI, spirometry, bronchial hyperreactivity (BHR), and fractional concentration of exhaled nitric oxide (FeNO) in a cohort of AR patients. " 01/01/2016 - "Exhaled nitric oxide (eNO), sputum eosinophils (sEos), and bronchial hyperreactivity (BHR) were assessed at the beginning and then every three months throughout the one-year period. " 07/01/2011 - "Good pulmonary distribution of ICS in patients with mild asthma is reflected by a better control of the disease, improvement in the quality of life, improvement in the results of pulmonary function tests, decreased levels of exhaled proinflammatory nitric oxide, lower number of inflammatory cells (including eosinophils) in the induced sputum, decrease in bronchial hyperreactivity, and decrease in exhaled air trapping observed in the computed tomographic scanning of the lungs."

Therapies and Procedures

1.	Therapeutics 10/01/1997 - "However, given the importance of beta2AR in modulating lung function, studies have been carried out to determine if polymorphic forms may play roles in promoting asthmatic phenotypes, establishing bronchial hyperreactivity, or influencing the response to acute or chronic beta-agonist therapy. " 05/10/2021 - "We describe a case of a 69-year-old Caucasian female patient, late diagnosis of AATD, with both severe bronchial hyperreactivity and numerous exacerbations due to the peculiar clinical history and the presence of a rare mutation; although not presenting forced expiratory volume in 1 second (FEV1) between 30 and 65%, the patient was treated with alpha-1 antitrypsin (AAT) augmentation therapy and achieved clinical and functional improvement. " 01/05/2005 - "Whereas treatment was ineffective on bronchial hyperreactivity and weakly inhibited eosinophil infiltrates, therapy with anti-IL-5 mAb resulted in a significant decrease in extracellular matrix deposition, suggesting a role for anti-IL-5 mAb in limiting bronchial remodeling." 08/01/1997 - "[Bronchial hyperreactivity and nCPAP therapy]." 08/01/1997 - "Our results demonstrate that in patients with increased bronchial reactivity, nCPAP therapy may aggravate bronchial hyperreactivity."
2.	Immunotherapy 11/01/2006 - "This immunotherapy modifies the natural course of the illness because it improves all clinical outcomes measured and prevents the worsening of specific bronchial hyperreactivity." 10/01/2000 - "2. No significant effects of specific immunotherapy on nonspecific bronchial hyperreactivity were found. " 10/01/2000 - "From these data the following conclusions were formulated: 1. Specific immunotherapy decreases specific bronchial hyperreactivity. " 10/01/2000 - "The aim of the paper was to answer the question, weather specific immunotherapy affected bronchial hyperreactivity in asthmatic patients. " 02/01/1986 - "Non-allergic bronchial hyperreactivity in asthmatic children decreases with age and increases with mite immunotherapy."
3.	Aftercare (After-Treatment) 01/01/1981 - "Pharmacological rehabilitation is defined as a decrease of bronchial hyperreactivity and a stabilization of the bronchial reactivity after treatment with drugs possessing prophylactic and therapeutic properties. " 07/01/2002 - "The primary endpoint of this study was to determine changes in serum levels of inflammatory markers after treatment with formoterol; secondary endpoints included clinical efficacy and bronchial hyperreactivity. " 04/01/1985 - "Modification of bronchial hyperreactivity after treatment with sodium cromoglycate during pollen season." 04/01/2002 - "A study of the relationships between spirometric indices, airway inflammation, airway remodelling, and bronchial hyperreactivity (BHR) before and after treatment with high dose inhaled fluticasone propionate (FP 750 microg bd) was performed in a group of patients with relatively mild but symptomatic asthma. " 01/01/2002 - "After treatment with nedocromil, clinical symptoms improved significantly, IL-10 serum levels and bronchial hyperreactivity did not change significantly (p = 0.094 and p = 0.09 respectively). "
4.	Climatotherapy 08/01/1992 - "The result of climatotherapy is an increased immunological resistance, hardening, reduced bronchial hyperreactivity and improved life of asthmatic patients. "
5.	Lasers (Laser) 03/01/2007 - "Laser acupuncture and probiotics significantly decreased mean (standard deviation) weekly PFV as a measurement of bronchial hyperreactivity by -17.4% (14.2) in the TCM group vs. 2.2% (22.5) in the control group (p = 0.034). " 03/01/2007 - "In conclusion, this pilot study generates the hypothesis that the interactive treatment of lung and large intestine according to TCM by laser acupuncture and probiotics has a beneficial clinical effect on bronchial hyperreactivity in school age children with intermittent or mild persistent asthma and might be helpful in the prevention of acute respiratory exacerbations. "