Ankle Injuries (Ankle Injury)

03/01/1991 - "In conclusion, diclofenac potassium has been demonstrated to be effective in the treatment of acute ankle sprains and it had a rapid onset of action and good tolerability."
01/01/2007 - "A previously published study comparing the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains is critically re-evaluated. "
08/01/2013 - "A prospective, randomized, double-blind, placebo-controlled, parallel-group multicentre study to evaluate the efficacy and safety of diclofenac 4% spray gel for the treatment of acute, uncomplicated ankle sprain. "
08/01/2013 - "A randomized, double-blind, placebo-controlled multicentre study to evaluate the efficacy and safety of diclofenac 4% spray gel in the treatment of acute uncomplicated ankle sprain."
08/01/2013 - "Outpatients with acute, uncomplicated, one-sided ankle sprain were randomly assigned to receive diclofenac 4% spray gel or placebo (vehicle) three times daily for 14 ± 1 days. "

09/12/2008 - "The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs."
04/01/2007 - "This study demonstrates that ESA of 2 Hz and 100 Hz shows comparable analgesic effects, but only 2 Hz ESA can facilitate the reduction of edema caused by ankle sprain."
03/01/2008 - "These data suggest that the analgesic effect of EA in ankle sprain pain is, at least in part, mediated by spinal alpha(2)-adrenoceptor mechanisms."
10/01/2002 - "These data suggest that EA produces a potent analgesic effect on the ankle sprain pain model in the rat. "
10/01/2002 - "the analgesic effect on the ankle sprain pain model could not be mimicked by EA applied to a nearby point, LI-4 and (2). "

12/01/2020 - "Our study suggests that there is little benefit from routinely using a regular scheduled ibuprofen regimen for acute pediatric ankle sprains."
09/01/1994 - "Evaluation of topical ibuprofen cream in the treatment of acute ankle sprains."
03/01/1989 - "Immediate high-dose ibuprofen is therefore recommended as treatment for moderate to severe acute ankle injuries."
01/01/1987 - "A double-blind study compared ibuprofen at a dose of 2,400 mg per day and a placebo in the 1st week of treatment of 61 acute ankle sprains with varying degrees of severity. "
12/01/1985 - "Variable schedules of ibuprofen for ankle sprains."

08/01/2002 - "Patient's Global Assessment of Ankle Injury responses, given on days 4 and 8, showed that the celecoxib group improved significantly more than the placebo group did, with 67% of the celecoxib group versus 55% of the placebo group improving at day 4 (P < .05). "
08/01/2002 - "Celecoxib, a cyclo-oxygenase-2-specific inhibitor with platelet-function-sparing properties, may be useful as a multimodal adjuvant in the treatment of ankle sprain."
11/01/2009 - "Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a Latin American and Middle Eastern population."
06/01/2006 - "Celecoxib, a COX-2 selective inhibitor, is as effective as diclofenac SR in treating ankle sprains. "
05/01/2005 - "Re: Efficacy of celecoxib, a COX-2-specific inhibitor, and naproxen in the management of acute ankle sprain: results of a double-blind, randomized controlled trial."

06/01/2011 - "Efficacy of paracetamol versus diclofenac for Grade II ankle sprains."
12/01/2007 - "The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium."
11/01/2006 - "This study had a noninferiority design in which the hypothesis was that acetaminophen extended release was not inferior to ibuprofen for treatment of signs and symptoms of grade I or II lateral ankle sprains. "
12/01/2007 - "It was concluded that diclofenac sodium and paracetamol are effective and well tolerated as a short term treatment alternatives for acute ankle injuries."
09/01/2007 - "Patients (N = 77, aged 8-14 y, 61% male) with ankle injuries presenting to a regional pediatric emergency department were assigned to receive either acetaminophen (15 mg/kg 4 times a day) or naproxen (5 mg/kg 4 times a day) in a double-blind fashion on a routine basis for a 5 day period. "

08/01/2020 - "The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in children presenting with ankle sprain to the ED. "
08/01/2020 - "Topical Ketoprofen Versus Placebo in Children Presenting With Ankle Sprain to the Emergency Department: A Randomized Controlled Study."
09/01/2016 - "The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in patients presenting with ankle sprain to the emergency department. "
04/01/2005 - "This trial suggested that a 7-day course of treatment with a ketoprofen patch is useful in benign ankle sprain, without revealing unexpected adverse events."
04/01/2005 - "Topical ketoprofen patch (100 mg) for the treatment of ankle sprain: a randomized, double-blind, placebo-controlled study."

07/14/2011 - "Pooled analysis of clinical trial data evaluating the safety and effectiveness of diclofenac epolamine topical patch 1.3% for the treatment of acute ankle sprain."
03/07/2011 - "Diclofenac epolamine topical patch relieves pain associated with ankle sprain."
01/01/2009 - "Previous studies have shown that 1 or 2 weeks of treatment with diclofenac epolamine provides pain relief for various localized musculoskeletal conditions such as ankle sprains, epicondylitis and knee osteoarthritis. "
09/01/2010 - "Results confirm the efficacy of DHEP heparin plaster compared with placebo for the treatment of painful ankle sprain with oedema. "
01/01/2011 - "Diclofenac epolamine plus heparin plaster versus diclofenac epolamine plaster in mild to moderate ankle sprain: a randomized, double-blind, parallel-group, placebo-controlled, multicentre, phase III trial."

06/01/2020 - "Weight-bearing MWM appears to be beneficial for improving weight-bearing dorsiflexion immediately after application for chronic recurrent ankle sprains compared to no treatment or sham. "
02/01/2021 - "To investigate whether Kinesio taping technique, applied to ankles of healthy people as a preventive intervention and people with ankle injuries, is superior to sham or alternative interventions on ankle function. "
01/01/2020 - "Randomized trials assessing the results of real and/or sham taping, wait-and-see protocols, ankle bracing, and foot orthotics for ankle instability as determined by one or more ankle sprains followed by ongoing subjective symptoms and/or mechanical laxity were included. "
01/01/2022 - "Methods: Male C57BL/6J mice were used and respectively subjected to a sham operation, calcaneofibular ligament (CFL) transection, and mechanical ankle sprains. "
04/01/2015 - "Thirty male mice (CBA/J) were randomly placed into a SHAM (control), CFL (calcaneofibular ligament; mild ankle sprain), or ATFL/CFL (anterior talofibular ligament/CFL; severe) ankle sprain group and housed individually. "

08/01/2010 - "Data from two double-blind, randomized, parallel-group, placebo-controlled studies (N = 274) of safety and efficacy of the DETP applied once daily for 7 days for acute ankle sprain were evaluated post-hoc using statistical modeling to estimate time to onset of significant pain reduction following DETP application. "
03/07/2011 - "Pain intensity was evaluated during the first six hours after application of the patch, and on treatment days 1, 2, 3, and 7. Patients treated with the DETP experienced a significantly greater reduction in pain associated with their ankle injury compared with placebo, beginning four hours after the first patch application (P = 0.02). "
08/01/2010 - "This retrospective post-hoc analysis examined time to onset of significant pain reduction after DETP application compared to a placebo patch for patients with mild-to-moderate acute ankle sprain, evaluating the primary efficacy endpoint from two nearly identical studies. "
07/14/2011 - "These results further confirm the efficacy and safety of DETP for the treatment of acute pain from ankle sprains. "
07/14/2011 - "This pooled analysis assessed the efficacy and safety of the diclofenac epolamine topical patch 1.3% (DETP) for the treatment of acute mild-to-moderate ankle sprain. "

12/24/2022 - "This was a phase 3, randomized, double-blind, multicenter, active-controlled, parallel-group study conducted in China from October 2019 to November 2020, designed to determine the noninferiority of DDEA 2.32% gel BID relative to DDEA 1.16% gel QID for treatment of grade I-II ankle sprain. "
09/01/2012 - "This randomized double-blind controlled study enrolled patients with acute ankle sprain treated with DDEA 2.32% gel two times per day (bid) (n = 80) or three times per day (tid) (n = 80) or placebo (n = 82). "
09/01/2012 - "DDEA 2.32% gel twice daily (applied in the morning and evening) was well tolerated and provided lasting relief from pain, improved function, and reduced symptomatic healing time in uncomplicated ankle sprain."
12/24/2022 - "Diclofenac diethylamine (DDEA) gel has demonstrated efficacy for treatment of ankle sprains in both the 1.16% four-times-daily (QID) and 2.32% twice-daily (BID) formulations. "

08/01/2013 - "There is good evidence from high level randomized trials in the literature that the use of a brace is effective for the prevention of ankle sprains. "
05/28/2012 - "Treatment of acute ankle sprain with semi-rigid brace leads to significantly higher patient comfort and satisfaction, both with similar good outcome."
10/01/1990 - "Nevertheless, the air stirrup has not been shown to provide significantly greater inversion restriction than taping or lace-on braces and is not recommended as a first-line method of support for individuals with no history of recent ankle sprain. "
10/01/2000 - "However, braces seem to be more effective in preventing ankle sprains than tape. "
07/01/2006 - "Although prophylactic ankle bracing has been shown to be effective in reducing the incidence of ankle sprains,how these ankle braces might affect the other joints of the lower extremity is not clearly understood. "

05/01/2013 - "Efficacy of thrust and nonthrust manipulation and exercise with or without the addition of myofascial therapy for the management of acute inversion ankle sprain: a randomized clinical trial."
01/01/2023 - "Our study found LAS model mice may be used as a preclinical animal model for screening novel targets or therapies for ankle sprain. "
01/01/2019 - "In this study, we assess the use of a neuromuscular electrical stimulation (NMES) device as an adjunctive therapy to reduce oedema in patients recovering from grade I and II ankle sprains. "
10/01/2015 - "Double-blind, Randomized, Placebo-controlled Study Evaluating the Use of Platelet-rich Plasma Therapy (PRP) for Acute Ankle Sprains in the Emergency Department."
07/01/2015 - "[Conclusion] This study showed that ankle inversion taping using kinesiology tape may be an effective therapy for a patient with a medial ankle sprain. "

01/01/1999 - "To examine the efficacy of 3 different types of injury support systems (standard elastic wrap with horseshoe, Aircast Sport Stirrup, and Omni Multiphase orthosis) used in treating acute inversion ankle sprains. "
04/01/1997 - "The results may assist clinicians in selecting either of these orthoses for use in protection against ankle sprain injury."
03/01/1994 - "The results may assist clinicians in selecting either of these orthoses for use in protection against ankle sprain injury."
03/01/1994 - "Clinicians often are faced with the task of selecting an ankle orthosis that will provide protection against ankle sprain injury and will not have a deleterious effect on functional performance. "
08/01/2019 - "This study aimed to determine the prophylactic stabilization effect for commonly prescribed ankle orthoses in a simulated recurrent ankle sprain. "

07/01/2001 - "Good results have been reported after both primary repair and conservative management of grade III ankle sprains. "
07/01/1999 - "Conservative therapy has been found to be uniformly effective in treating grade I and II ankle sprains. "
01/01/2022 - "The main objective of the literature search was to identify the randomized trials comparing: (1) surgery to conservative management, (2) different external supports, and (3) different rehabilitation protocols for the treatment of acute lateral ankle sprains. "
02/05/2021 - "A meta-analysis of randomized controlled trials comparing traditional Chinese manipulation and other conservative therapy for ankle sprains was conducted. "
10/01/2023 - "Conservative Management of Acute Lateral Ligaments of the Ankle Injuries: An Analytical Literature Review."

08/01/2006 - "To compare the efficacy of an intermittent cryotherapy treatment protocol with a standard cryotherapy treatment protocol in the management of acute ankle sprains. "
12/01/2022 - "The purpose of this study was to compare Functional and Kinetic Treatment with Rehabilitation (FAKTR) combined with cryotherapy to cryotherapy alone in the treatment of acute grade I or II inversion ankle sprains. "
01/01/2017 - "The results of the present trial showed that using BIOPTRON LIGHT and cryotherapy the rehabilitation period of acute ankle sprains can be reduced."
01/01/2012 - "Therefore, the primary objective of this study was to determine the effectiveness of the cryotherapy wrap compared to a traditional treatment in the management of acute ankle sprains. "
12/19/2007 - "This paper describes the rationale and design of a randomised controlled trial which will examine the effectiveness of two different cryotherapy protocols in the early management of acute ankle sprain. "