AIDS-Related Lymphoma (Lymphoma, AIDS Related)

B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.

Also Known As:

Networked: 204 relevant articles (18 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS)
2.	Neoplasms (Cancer)
3.	Kaposi Sarcoma (Kaposi's Sarcoma)
4.	Opportunistic Infections (Opportunistic Infection)
5.	Lymphoma (Lymphomas)

Experts

1.	Ribera, Josep-Maria: 6 articles (08/2021 - 03/2003)
2.	Krishnan, Amrita: 6 articles (01/2021 - 10/2002)
3.	Noy, Ariela: 6 articles (01/2021 - 01/2013)
4.	Spina, Michele: 6 articles (01/2015 - 09/2004)
5.	Hoffmann, Christian: 5 articles (01/2018 - 07/2003)
6.	Tirelli, Umberto: 5 articles (01/2015 - 05/2006)
7.	Oriol, Albert: 5 articles (11/2014 - 09/2002)
8.	Carbone, A: 5 articles (07/2001 - 08/2000)
9.	Gaidano, G: 5 articles (07/2001 - 08/2000)
10.	Kaplan, Lawrence D: 4 articles (01/2021 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to AIDS-Related Lymphoma:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/01/2006 - "To evaluate in a pilot study the safety and efficacy of liposomal doxorubicin, cyclophosphamide, and etoposide (LACE) when combined with antiretroviral therapy (ART) in patients with AIDS-related lymphoma (ARL). " 06/01/2006 - "Liposomal doxorubicin, cyclophosphamide, and etoposide and antiretroviral therapy for patients with AIDS-related lymphoma: a pilot study." 01/01/2023 - "Phase II trial of a novel chemotherapy regimen CVEP (cyclophosphamide, vinblastine, etoposide and prednisolone) for acquired immunodeficiency syndrome (AIDS)-associated lymphomas." 05/01/2001 - "An infusional regimen called EPOCH (etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, doxorubicin HCl) shows promise in the future management of AIDS-related lymphoma. " 09/01/2005 - "Liposomal encapsulation of doxorubicin when substituted for doxorubicin in the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, prednisone) seems to overcome P-glycoprotein-mediated drug resistance in AIDS-related lymphoma. "
2.	Etoposide (VP 16)FDA LinkGeneric 06/01/2006 - "To evaluate in a pilot study the safety and efficacy of liposomal doxorubicin, cyclophosphamide, and etoposide (LACE) when combined with antiretroviral therapy (ART) in patients with AIDS-related lymphoma (ARL). " 06/01/2006 - "Liposomal doxorubicin, cyclophosphamide, and etoposide and antiretroviral therapy for patients with AIDS-related lymphoma: a pilot study." 11/01/2009 - "Because of the poor prognosis of AIDS-related lymphoma, he received autologous peripheral blood stem cell transplantation with the MEAM protocol (ranimustine, etoposide, cytarabine, melphalan) as a conditioning procedure without a severe infectious episode. " 01/01/2023 - "Phase II trial of a novel chemotherapy regimen CVEP (cyclophosphamide, vinblastine, etoposide and prednisolone) for acquired immunodeficiency syndrome (AIDS)-associated lymphomas." 05/01/2001 - "An infusional regimen called EPOCH (etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, doxorubicin HCl) shows promise in the future management of AIDS-related lymphoma. "
3.	Vincristine (Oncovin)FDA LinkGeneric 09/01/2005 - "This can be achieved by developing targeted anti-viral and other strategies, such as the use of bryostatin 1 and vincristine, and by developing a preclinical mouse model to frame the clinical rationale for a pilot trial of metronomic therapy for the treatment of Burkitt's and AIDS-related lymphoma. " 12/01/2012 - "We evaluated risk factors for neutropenic fever and febrile prolonged neutropenia during vincristine-including chemotherapy to treat HIV-related lymphoma to investigate whether protease inhibitor (PI) treatment is associated with infectious complications due to drug interactions with chemotherapeutic agents. " 05/01/2001 - "An infusional regimen called EPOCH (etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, doxorubicin HCl) shows promise in the future management of AIDS-related lymphoma. " 09/01/2005 - "Liposomal encapsulation of doxorubicin when substituted for doxorubicin in the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, prednisone) seems to overcome P-glycoprotein-mediated drug resistance in AIDS-related lymphoma. " 02/01/2008 - "Immunochemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone and rituximab (R-CHOP) is the standard treatment in non-immunosuppressed patients with diffuse large B-cell lymphoma (DLBCL), but its adequacy has not been definitively established in patients with human immunodeficiency virus (HIV)-related lymphoma. "
4.	Rituximab (Mabthera)FDA Link 01/01/2023 - "Rituximab did not appear to improve outcome in HIV-related lymphomas." 11/01/2014 - "We randomly divided a dataset of 487 patients newly diagnosed with AIDS-related lymphomas and treated with rituximab-containing chemoimmunotherapy into a training (n=244) and validation (n=243) set. " 11/01/2014 - "A new prognostic score for AIDS-related lymphomas in the rituximab-era." 02/20/2012 - "Treatment of AIDS-related lymphomas: rituximab is beneficial even in severely immunosuppressed patients." 04/01/2006 - "The case for rituximab in AIDS-related lymphoma."
5.	Monoclonal AntibodiesIBA 01/01/2014 - "Since the introduction of highly active antiretroviral therapy (HAART) (1) and later on the availability of anti-CD20 monoclonal antibody treatment (2), the therapeutic options as well as the prognosis of AIDS related lymphoma (ARL) have been improved. " 01/01/2003 - "She addresses current controversies in the pathogenesis of HIV related lymphomas and summarizes a number of recent trials of combination chemotherapy, with or without monoclonal antibodies, in their management. " 09/01/1998 - "Immunotherapy, monoclonal antibodies, and adoptive immunotherapy targeting Epstein Barr virus (EBV) all represent novel experimental treatment approaches that are becoming possible based on our increased understanding of the pathogenesis of HIV-related lymphoma. " 11/01/1997 - "In post-transplantation lymphoproliferative disorders and AIDS related lymphomas, EBV latency type III can be detected by immunohistochemistry in a subpopulation of tumour cells using sensitive monoclonal antibodies R3 and 3E9. " 11/01/1997 - "Nine post-transplantation lymphoproliferative disorders and three AIDS related lymphomas were subjected to immunohistochemistry using monoclonal antibodies specific for EBV nuclear antigen 1 (EBNA1) (2H4), EBNA2 (PE2 and the new rat anti-EBNA2 monoclonal antibodies 1E6, R3, and 3E9), and LMP1 (CS1-4 and S12). "
6.	Prednisone (Sone)FDA LinkGeneric 05/01/2001 - "An infusional regimen called EPOCH (etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, doxorubicin HCl) shows promise in the future management of AIDS-related lymphoma. " 09/01/2005 - "Liposomal encapsulation of doxorubicin when substituted for doxorubicin in the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, prednisone) seems to overcome P-glycoprotein-mediated drug resistance in AIDS-related lymphoma. " 02/01/2008 - "Immunochemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone and rituximab (R-CHOP) is the standard treatment in non-immunosuppressed patients with diffuse large B-cell lymphoma (DLBCL), but its adequacy has not been definitively established in patients with human immunodeficiency virus (HIV)-related lymphoma. " 01/01/2013 - "Pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047."
7.	liposomal doxorubicin (Doxil)FDA Link 06/01/2006 - "To evaluate in a pilot study the safety and efficacy of liposomal doxorubicin, cyclophosphamide, and etoposide (LACE) when combined with antiretroviral therapy (ART) in patients with AIDS-related lymphoma (ARL). " 06/01/2006 - "Liposomal doxorubicin, cyclophosphamide, and etoposide and antiretroviral therapy for patients with AIDS-related lymphoma: a pilot study." 01/01/2013 - "Pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047."
8.	Doxorubicin (Adriamycin)FDA LinkGeneric 05/01/2001 - "An infusional regimen called EPOCH (etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, doxorubicin HCl) shows promise in the future management of AIDS-related lymphoma. " 09/01/2005 - "Liposomal encapsulation of doxorubicin when substituted for doxorubicin in the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, prednisone) seems to overcome P-glycoprotein-mediated drug resistance in AIDS-related lymphoma. " 02/01/2008 - "Immunochemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone and rituximab (R-CHOP) is the standard treatment in non-immunosuppressed patients with diffuse large B-cell lymphoma (DLBCL), but its adequacy has not been definitively established in patients with human immunodeficiency virus (HIV)-related lymphoma. " 09/01/1993 - "The recommended treatment of AIDS-associated lymphoma by Levine is a low-dose modification of the M-BACOD (bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone, cytosine arabinoside, azidothymidine and helmet field radiotherapy). "
9.	Protease Inhibitors (Protease Inhibitor)IBA 10/01/1999 - "The use of modern antiretroviral therapy improved the prognosis of patients with AIDS-related lymphoma, because patients could receive adequate dose intensity of chemotherapy and the presence of opportunistic infections secondary to AIDS declines with the use of protease inhibitors. " 12/01/2012 - "We evaluated risk factors for neutropenic fever and febrile prolonged neutropenia during vincristine-including chemotherapy to treat HIV-related lymphoma to investigate whether protease inhibitor (PI) treatment is associated with infectious complications due to drug interactions with chemotherapeutic agents. "
10.	DNA (Deoxyribonucleic Acid)IBA 12/01/2017 - "Further studies are merited to determine whether plasma clonal Ig DNA is prognostic in HIV-related lymphomas." 10/01/1996 - "The purpose of this study was to determine the in situ distribution of PCR-amplified HIV-1 and EBV DNA in hyperplastic lymph nodes and in AIDS-related lymphomas. " 05/01/2010 - "Recurrent chromosomal alterations in molecularly classified AIDS-related lymphomas: an integrated analysis of DNA copy number and gene expression." 12/01/2005 - "Epstein-Barr Virus DNA quantification: an adjunctive diagnostic marker for AIDS-associated lymphoma." 06/01/2004 - "EBV DNA was almost always naked in the plasma of AIDS-related lymphoma patients (n = 11) and immunosuppressed/posttransplantation patients (n = 8). "

Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART) 10/01/2013 - "Since the introduction of highly active antiretroviral therapy (HAART), recent studies have documented improved survival outcome in patients with AIDS-related lymphomas. " 12/15/2017 - "Treatment outcomes for patients with HIV-related lymphoma have improved since the advent of combination antiretroviral therapy. " 03/01/2003 - "Improved outcome of AIDS-related lymphoma in patients with virologic response to highly active antiretroviral therapy." 09/01/2002 - "Improved immune function in HIV seropositive patients treated with highly active antiretroviral therapy appears to be reducing the relative risk of AIDS-related lymphoma. " 12/01/2019 - "While studies have shown an increased survival for patients with most kinds of HIV-related lymphomas since the introduction of highly active antiretroviral therapy (HAART), the impact of HAART on survival in patients with HIV-related PBL is unclear, mainly because the condition is rare and the number of published studies is small. "
2.	Therapeutics 12/01/1997 - "Daily low-dose rIL-2 therapy may be effective in treating or preventing AIDS-associated lymphoma without amplifying HIV replication." 01/01/1999 - "Combination therapy approaches may also be helpful in HIV-related lymphomas. " 10/01/1996 - "With improved survival because of antiretroviral therapy, the incidence of AIDS-related lymphomas is expected to rise. " 05/01/2015 - "Individual patient data had been obtained prior from prospective phase II or III clinical trials carried out between 1990 until 2010 in North America and Europe that studied chemo(immuno)therapy in HIV-positive patients diagnosed with AIDS-related lymphomas. " 12/01/1997 - "Results of the hu-PBL-SCID mouse model and the phase I study have led to a national trial of low-dose rIL-2 therapy in AIDS-associated lymphoma. "
3.	Drug Therapy (Chemotherapy) 01/01/2018 - "In total, 254 of 399 (63.7%) patients with AIDS-related lymphomas reached a complete remission with their first-line chemotherapy. " 01/01/1999 - "This study indicates that standard chemotherapy could be useful in patients with AIDS-associated lymphoma because CR rate, duration of remission, and survival were similar to those with other intensive, but more toxic, regimens. " 04/01/1991 - "Although very intensive regimens of multiagent chemotherapy have been employed in patients with HIV-related lymphoma, several studies indicate that these patients may not be able to tolerate such dose intensity. " 01/01/2021 - "Clinical observations of bone marrow transfusion for promoting bone marrow reconstruction after chemotherapy for AIDS-related lymphoma." 01/01/2013 - "Infusional chemotherapy is efficacious in patients with AIDS-related lymphoma, but it may be difficult to administer. "
4.	Art Therapy 06/01/2006 - "To evaluate in a pilot study the safety and efficacy of liposomal doxorubicin, cyclophosphamide, and etoposide (LACE) when combined with antiretroviral therapy (ART) in patients with AIDS-related lymphoma (ARL). "
5.	Hematopoietic Stem Cell Transplantation 01/01/2020 - "Autologous hematopoietic stem cell transplantation (ASCT) is a well-established treatment strategy in HIV-related lymphoma patients (HIV+ Ly). " 09/01/2004 - "High-dose therapy plus autologous hematopoietic stem cell transplantation for human immunodeficiency virus (HIV)-related lymphoma: results and impact on HIV disease." 09/01/2004 - "The aim of this study was to assess the feasibility of high-dose chemotherapy plus autologous hematopoietic stem cell transplantation (HDC/AHSCT) in AIDS-related lymphoma (ARL), and its long-term impact in patients with human immunodeficiency virus (HIV) treated with highly active antiretroviral therapy (HAART). " 01/01/2021 - "Immune Recovery Following Autologous Hematopoietic Stem Cell Transplantation in HIV-Related Lymphoma Patients on the BMT CTN 0803/AMC 071 Trial." 08/01/2013 - "Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma."