Helicobacter Infections

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

Also Known As:

Networked: 218 relevant articles (16 outcomes, 32 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer)
2.	Peptic Ulcer (Peptic Ulcers)
3.	Neoplasms (Cancer)
4.	Bacterial Infections (Bacterial Infection)
5.	Marginal Zone B-Cell Lymphoma (MALT Lymphoma)

Experts

1.	Merchant, Juanita L: 6 articles (01/2022 - 10/2003)
2.	Fox, James G: 6 articles (06/2011 - 03/2003)
3.	Avramenko, Anatoly A: 5 articles (01/2020 - 01/2019)
4.	Ferrero, Richard L: 5 articles (01/2020 - 02/2008)
5.	Zavros, Yana: 4 articles (01/2022 - 10/2003)
6.	Varro, Andrea: 4 articles (01/2012 - 03/2003)
7.	Michetti, Pierre: 4 articles (10/2011 - 10/2006)
8.	Wang, Timothy C: 4 articles (06/2011 - 03/2003)
9.	Sutton, Philip: 3 articles (04/2020 - 01/2012)
10.	Chonwerawong, Michelle: 3 articles (01/2020 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Helicobacter Infections:

1.	VaccinesIBA 06/01/2015 - "Host Nonresponsiveness Does not Interfere With Vaccine-Mediated Protection Against Gastric Helicobacter Infection." 10/01/2011 - "PAR2 activates DCs to mediate vaccine-induced protection against Helicobacter infection in mice." 10/01/2011 - "PAR2 promotes vaccine-induced protection against Helicobacter infection in mice." 04/01/1999 - "Results of vaccine studies in mouse models indicate that modulating the helper T cell response from a T helper cell type 1 to a T helper cell type 2 response likely is required for the prevention and elimination of helicobacter infection. " 03/18/1997 - "Finally, the Helicobacter infection of animals seems to be an interesting model not only in the study of the affections caused by these bacteria, but also in the elaboration of a future vaccine against the H. "
2.	AntigensIBA 11/01/1994 - "The study demonstrated that a recombinant subunit antigen could induce an immunoprotective response against gastric Helicobacter infection." 01/01/2019 - "Upon Helicobacter infection, CD4+ Trm cells orchestrate a swift recall response with the recruitment of circulating antigen-specific Th1/Th17 cells to trigger a tissue-wide pathogen clearance. " 09/01/2003 - "Gastric Helicobacter infection inhibits development of oral tolerance to food antigens in mice." 09/01/1997 - "Mucosal vaccination using different antigens in conjunction with adjuvants has been used for the prevention and even cure of Helicobacter infection in animal models. " 07/03/1995 - "pylori as potential protective antigens in a murine model of gastric Helicobacter infection. "
3.	UreaseIBA 03/01/1994 - "Lack of protection against gastric Helicobacter infection following immunisation with jack bean urease: the rejection of a novel hypothesis." 01/01/2020 - "Comprehensive examination included: step-by-step intragastric pH-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous, material for which was taken during endoscopy from 4 topographical zones: from the middle third of the gastric antrum and body of stomach on the big and small curvature. " 01/01/2020 - "Comprehensive examination included: step-by-step intragastric pH-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous, material for which was taken during endoscopy from 4 topographical zones: from the middle third of the gastric antrum and body of stomach on the big and small curvature. " 01/01/2020 - "Comprehensive examination included: step-by-step рН-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous. " 10/31/2019 - "The 36 patients took comprehensive examination: step-by-step рН-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous, stool test, HELIC – test, the level of natural killers (CD-16). "
4.	bismuth tripotassium dicitrate (bismuth subcitrate)IBA 01/01/1991 - "[Assessment of the efficacy of de-nol and bismuth subnitrate treatment of patients with associated peptic ulcer and pyloric Helicobacter infection (experimental and clinical studies)]." 01/01/1995 - "Antacids and colloidal bismuth subcitrate decreased both the chronic active gastritis of praepyloric region and frequency of Helicobacter infection, however without the full eradication. "
5.	InterleukinsIBA 06/01/2009 - "This study explores the possibility that interleukin (IL)-17 plays a role in the reduction of Helicobacter infection following vaccination of wild-type animals or in spontaneous reduction of bacterial infection in IL-10-deficient mice. "
6.	sitafloxacinIBA 10/13/2021 - "Therefore, we aimed to investigate the therapeutic potential of sitafloxacin as a first-line treatment for patients with Helicobacter infection through gastric tissue culture-based studies. "
7.	bismuth subnitrate (Roter)IBA 01/01/1991 - "[Assessment of the efficacy of de-nol and bismuth subnitrate treatment of patients with associated peptic ulcer and pyloric Helicobacter infection (experimental and clinical studies)]."
8.	LactoferrinIBA 12/01/2000 - "These results show that recombinant human lactoferrin is effective in a mouse model of Helicobacter infection, and support further testing of this promising agent for this application." 01/01/2002 - "Lactoferrin has significant, orally active in vivo actions and should be further investigated for clinical situations involving Helicobacter infections where it may have utility when administered alone and also when given in combination with established antibiotic agents."
9.	Inosine Triphosphate (ITP)IBA 01/01/2010 - "To confirm the long term efficacy of Helicobacter eradication on platelet counts in non-ITP patients, we evaluated changes in peripheral platelet counts in endoscopically diagnosed patients with Helicobacter infection. "
10.	Fatty Acids (Saturated Fatty Acids)IBA 12/01/2017 - "Protective efficacy of a hydroxy fatty acid against gastric Helicobacter infections."

Therapies and Procedures

1.	Therapeutics 04/07/2003 - "pylori colonization factors and may help to potentiate the development of novel therapies against gastric Helicobacter infections." 02/15/2022 - "Evaluation of the efficacy and safety of eradication therapy of infection Helicobacter pylori in patients with H. " 01/01/2021 - "Finally, we analyzed the relationship between non-Helicobacter pylori helicobacter infection status and eradication therapy outcome. " 02/02/2016 - "This indicates that Gln and GSH supplementation may help reducing tissue damage caused by Helicobacter infection in both humans and pigs, highlighting their potential as a supportive therapy during and after Helicobacter eradication therapy. " 05/28/2015 - "Modified sequential therapy vs quadruple therapy as initial therapy in patients with Helicobacter infection."
2.	Aftercare (After-Treatment) 10/01/2000 - "However, anti-FcepsilonRIalpha was also found in patients who went into remission after treatment of identified causes; namely, in one with type I allergy, one with drug intolerance, one with Helicobacter infection, and six with food intolerance. "
3.	Investigational Therapies (Experimental Therapy) 01/10/2017 - "Combined with helicobacter infection and carcinogens treatment, these transgenic/knockout/knockin mice developed precancerous or cancerous lesions, which are proper for gene function study or experimental therapy. "
4.	Gastrectomy 05/01/2021 - "Our study confirms that Helicobacter infection is significantly associated with postoperative complications after sleeve gastrectomy. "
5.	Oral Administration 10/01/2010 - "These TonB-expressing plants are highly suitable for animal studies of oral administration as a route for immunization against Helicobacter infections."