Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)

Condition characterized by large, rapidly extending, erythematous, tender plaques on the upper body usually accompanied by fever and dermal infiltration of neutrophilic leukocytes. It occurs mostly in middle-aged women, is often preceded by an upper respiratory infection, and clinically resembles ERYTHEMA MULTIFORME. Sweet syndrome is associated with LEUKEMIA.

Also Known As:

Acute Febrile Neutrophilic Dermatosis; Gomm Button Disease; Gomm-Button Disease; Disease, Gomm Button; Disease, Gomm-Button; Sweets Syndrome; Syndrome, Sweet; Syndrome, Sweet's; Dermatosis, Neutrophilic, Febrile, Acute; Neutrophilic Dermatosis, Acute Febrile; Sweet's Syndrome

Networked: 618 relevant articles (35 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Erythema: 8083
    - Sweet Syndrome: 618

Related Diseases

1.	Pyoderma Gangrenosum
2.	Myelodysplastic Syndromes (Myelodysplastic Syndrome)
3.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
4.	Sarcoidosis (Schaumann Disease)
5.	Skin Diseases (Skin Disease)

Experts

1.	Cohen, Philip R: 7 articles (04/2015 - 01/2002)
2.	Fraga, Javier: 4 articles (10/2020 - 07/2005)
3.	Marzano, A V: 4 articles (01/2017 - 10/2010)
4.	Chaiwarith, Romanee: 3 articles (01/2022 - 10/2013)
5.	Chiewchanvit, Siri: 3 articles (01/2022 - 06/2020)
6.	Chuamanochan, Mati: 3 articles (01/2022 - 06/2020)
7.	Tarbox, Michelle: 3 articles (01/2022 - 01/2021)
8.	Tovanabutra, Napatra: 3 articles (01/2022 - 06/2020)
9.	Battistella, Maxime: 3 articles (11/2021 - 06/2012)
10.	Llamas-Velasco, Mar: 3 articles (10/2020 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sweet Syndrome:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2022 - "Here we present a case of Sweet syndrome in a young woman with rare extracutaneous manifestations, including bone and splenic fluid collections, with marked improvement following treatment with systemic corticosteroids. " 04/01/2017 - "The initiation of IV corticosteroids, the gold-standard treatment for necrotizing Sweet syndrome, lead to significant clinical improvement. " 03/01/2012 - "Sweet's syndrome can often be effectively treated with a brief course of systemic corticosteroids. " 07/26/2007 - "Systemic corticosteroids are the therapeutic gold standard for Sweet's syndrome. " 05/01/2023 - "Ayurvedic modalities may be a better treatment option in rare skin conditions like sweet syndrome, where corticosteroid usage failed to improve. "
2.	SteroidsIBA 05/01/2004 - "In each patient, the skin lesions of Sweet's syndrome relapsed many times while they still had NTMI, and these lesions usually responded well to short courses of systemic steroids without any deterioration of NTMI." 10/01/2017 - "Patients with Sweet syndrome demonstrate a complete and rapid response to systemic steroid administration. " 06/01/1995 - "Use of systemic steroids is the treatment of choice for Sweet syndrome. " 07/01/1992 - "Extracutaneous manifestations of Sweet's syndrome: steroid-responsive culture-negative pulmonary lesions." 08/01/1989 - "The short course of the disease in this patient suggests the possibility of postponing steroid treatment for one week in all patients with acute febrile neutrophilic dermatosis."
3.	Colchicine FDA LinkGeneric 08/01/2002 - "Long-term suppression of chronic Sweet's syndrome with colchicine." 03/01/1999 - "Colchicine for Sweet's syndrome. " 01/01/1990 - "The therapeutic effectiveness of colchicine is also presented as one treatment for Sweet's syndrome, because rapid regression of the lesions was noticed." 01/01/1983 - "Colchicine in the treatment of acute febrile neutrophilic dermatosis (Sweet's syndrome)." 10/01/1981 - "Treatment of acute febrile neutrophilic dermatosis (Sweet's syndrome) with colchicine."
4.	Azacitidine (5 Azacytidine)FDA Link 12/26/2022 - "Azacytidine-induced Sweet's syndrome." 08/01/2021 - "Sweet's syndrome was completely treated after the first cycle of 5-azacytidine. " 01/01/2020 - "A case of polycyclic Sweet's syndrome arising from azacitidine injection sites in myelodysplasia." 08/01/2018 - "Azacitidine-induced Sweet syndrome: Two unusual clinical presentations." 07/01/2015 - "Histiocytoid Variant of Sweet Syndrome Associated with Azacitidine and Recurrence upon Rechallenge."
5.	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/01/2011 - "Efficacy of anti-interleukin-1 receptor antagonist anakinra (Kineret®) in a case of refractory Sweet's syndrome." 04/24/2019 - "Refractory Sweet Syndrome Treated with Anakinra." 03/01/2016 - "Since initiating anakinra, the patient has had no recurrences of Sweet Syndrome. " 11/01/2012 - "The results show that anakinra is currently used clinically for the treatment of a variety of skin conditions such as psoriasis, atopic dermatitis, photoagaing, melanoma, Schnitzler syndrome, pyoderma gangraenosum, PAPA syndrome, hidradenitis suppurativa, lamellar ichthyosis, Sweet's syndrome, panniculitis, Muckle-Wells syndrome, familial Mediterranean fever, SAPHO syndrome and other disorders. " 02/01/2008 - "Efficacy of anakinra, an IL1 receptor antagonist, in refractory Sweet syndrome."
6.	CytokinesIBA 01/01/2022 - "Finally, we review the molecular and cellular mechanisms connecting cytokine dysregulation to Sweet syndrome." 08/01/2021 - "Proinflammatory cytokines are considered to play a vital role in the pathogenesis of both RA and Sweet's syndrome. " 07/02/2017 - "This is the first case report of pediatric Sweet's syndrome in which serum cytokine levels were investigated. " 07/02/2017 - "To the best of our knowledge, no report has documented the cytokine profile in a pediatric patient with Sweet's syndrome. " 07/02/2017 - "Serum cytokine profile in pediatric Sweet's syndrome: a case report."
7.	Dapsone FDA Link 08/01/2015 - "Histopathology and clinical findings were consistent with the development of Sweet's syndrome and resolution was obtained after the initiation of dapsone. " 12/01/1990 - "Dapsone in Sweet syndrome." 02/01/1984 - "To the best of my knowledge, this is the first reported case of Sweet's syndrome in which dapsone therapy was used successfully." 04/01/2014 - "Treatment of giant cellulitis-like Sweet syndrome with dapsone." 08/01/2008 - "Dapsone-responsive histiocytoid Sweet's syndrome associated with Crohn's disease."
8.	Anti-Bacterial Agents (Antibiotics)IBA 10/15/2014 - "This is the second report of Sweet syndrome related to these antibiotics and the first associated with ocular, joint, and neurologic involvement." 11/01/2012 - "Pulmonary symptoms unresponsive to antibiotics in patients with Sweet syndrome should raise suspicion for neutrophilic infiltration." 01/31/2023 - "Diagnosing lung cancer with Sweet's syndrome is not easy, when there is a fever with an unknown cause and erythemas, especially when the erythemas do not disappear after antibiotic treatment, a skin biopsy is much important. " 10/15/2014 - "Sweet syndrome with panniculitis, arthralgia, episcleritis, and neurologic involvement precipitated by antibiotics." 06/01/2016 - "Because the signs and symptoms of Sweet's syndrome resemble an infectious process, the correct diagnosis may be delayed and inappropriate treatment regimen with antibiotics may often precede glucocorticoid therapy. "
9.	Prednisone (Sone)FDA LinkGeneric 03/27/2012 - "Skin biopsy revealed neutrophilic dermal infiltrates, leading to the diagnosis of Sweet's syndrome and prednisone (1 mg/kg) was initiated. " 01/01/2010 - "In both patients, histological examination confirmed clinical suspicion of Sweet syndrome and both had a good response on prednisone. " 10/01/2007 - "A differential diagnosis of Wells or Sweet's syndrome was entertained, and he was placed on 60 mg/day prednisone with no resolution of his symptoms. " 03/01/2004 - "These findings are consistent with a diagnosis of Sweet syndrome, and the patient was treated with 30 mg of oral prednisone. " 02/01/2000 - "This patient had been previously treated with prednisone for Sweets Syndrome. "
10.	Potassium Iodide (Pima)FDA Link 03/01/2018 - "We discuss calculation of a pediatric dosage for potassium iodide in Sweet syndrome." 03/01/2018 - "Potassium iodide in refractory, recurrent pediatric Sweet syndrome: Guidance in dosing and monitoring." 09/01/1998 - "Neutrophil-poor Sweet's syndrome with response to potassium iodide." 09/01/1987 - "Sweet's syndrome: a report on the use of potassium iodide." 01/01/1987 - "A case of Sweet's syndrome treated with potassium iodide is hereby described. "

Therapies and Procedures

1.	Therapeutics 07/26/2007 - "The symptoms and lesions of Sweet's syndrome may resolved spontaneously, without any therapeutic intervention; however, recurrence may follow either spontaneous remission or therapy-induced clinical resolution." 01/01/2019 - "Continued investigations into effective treatments and targeted therapy will benefit patients and improve our molecular understanding of inflammatory diseases, including Sweet's syndrome." 03/01/2014 - "Because of the challenging and extensive differential diagnosis of an acute bullous eruption in an immunocompromised child, we highlight the importance of a prompt and precise diagnosis before initiation of any systemic therapy in children with Sweet's syndrome. " 10/01/1995 - "Treatment with ATRA for APL was continued and no other additional therapy for Sweet's syndrome was performed. " 05/01/2017 - "She was diagnosed with a recurrence of Sweet's syndrome, and was exclusively treated with granulocyte and monocyte adsorption apheresis (GMA) therapy once a week for 3 consecutive weeks. "
2.	Off-Label Use 11/01/2008 - "Numerous case reports featuring its off-label use suggest the drug could be helpful in treating hidradenitis suppurativa, pyoderma gangrenosum, Sweet's syndrome, cutaneous sarcoidosis, pemphigus, systemic vasculitides, multicentric reticulohistiocytosis and stomatitis." 01/01/2019 - "The "off-label" use of infliximab is beneficial for relapsing and resistant Sweet's syndrome."
3.	Drug Therapy (Chemotherapy) 01/01/1985 - "Six courses of chemotherapy were given during which the lesions of Sweet's syndrome resolved completely. " 02/01/1998 - "Post-chemotherapy Sweet's syndrome in three patients with AML." 02/01/1998 - "Sweet's syndrome was not originally suspected in these patients because of the low peripheral white blood cell counts caused by chemotherapy. " 01/01/2022 - "Chemotherapy-induced Sweet's syndrome in a patient with recurrent laryngeal carcinoma." 01/01/2019 - "Sweet syndrome repeatedly occurred after the recovery of neutropenia due to chemotherapy. "
4.	Remission Induction 08/01/2008 - "We report a case of acute myeloid leukemia with folliculitis, Sweet's syndrome, and neutrophilic panniculitis after remission induction chemotherapy for acute myeloid leukemia. " 12/01/2011 - "Cyclophosphamide therapy was highly effective in steroid-refractory Crohn's colitis accompanied by Sweet's syndrome for induction of remission. "
5.	Plasmapheresis 01/01/2009 - "Intralesional corticosteroid therapy for patients with Sweet syndrome and pyoderma gangrenosum, hyperbaric oxygen and plasmapheresis for patients with pyoderma grangrenosum, and phototherapy for patients with subcorneal pustular dermatosis are other modalities that have been used effectively for treating individuals with these neutrophilic dermatoses."