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Proto-Oncogene Proteins pp60(c-src) (pp60 c-src)

Membrane-associated tyrosine-specific kinases encoded by the c-src genes. They have an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to PP60(V-SRC) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase.
Also Known As:
pp60 c-src; Phosphoprotein pp60(c-src); Proto-Oncogene Protein pp60(c-src); Proto-Oncogene Protein src; src Proto-Oncogene Product; Protein pp60, c-src; Protein src, Proto-Oncogene; Proto Oncogene Protein src; Proto-Oncogene Product, src; c src Protein pp60; c-src, pp60; pp60 c src; pp60, c-src Protein; src Proto Oncogene Product; src Proto Oncogene Protein pp60; c-src Protein pp60; pp60(c-src); src Proto-Oncogene Protein pp60
Networked: 22 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bonham, K: 2 articles (01/2001 - 01/2000)
2. Branch, Donald R: 1 article (06/2014)
3. Jung, Daniel: 1 article (06/2014)
4. McCarthy, Stephen D S: 1 article (06/2014)
5. Sakac, Darinka: 1 article (06/2014)
6. Işgör, Yasemin G: 1 article (12/2008)
7. Kiliç, Zuhal: 1 article (12/2008)
8. Olgen, Süreyya: 1 article (12/2008)
9. Higgins, Craig E: 1 article (03/2008)
10. Higgins, Paul J: 1 article (03/2008)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Carcinoma (Carcinomatosis)
03/01/1997 - "These data demonstrate that the activation of pp60(c-src) alone contributes to the tumorigenicity of HT 29 cells, a cell line widely used as a model for biological properties of colon carcinoma. "
07/01/2001 - "In this study, Csk activity and pp60(c-src) activity were examined in colorectal tumors as well as in colon carcinoma cell lines. "
08/01/1996 - "Protein levels of pp60(c-src) and pp62(c-yes) in primary carcinomas and metastases remained unchanged from levels in normal colonic mucosa. "
12/01/1999 - "AIM:To investigate the activation, expression of c-src gene and its role in the carcinogenetic process of human cardia adenocarcinoma (CA).METHODS:Fifty six cases of CA, 34 cases of normal, 36 cases of protiferative epithelia adjacent to carcinoma, and 20 cases of lymph node metastases of CA were studied for PP60(c-src),the expression product of c-src gene immunohistochemically by using the specific monoclonal antibody,Mab327.RESULTS: The positive rates of PP60(c-src) in the normal epithelia,protiferative epithelia, CA and lymph node metastases were 29.4% (10/34), 94.4% (34/36), 71.4% (40/56) and 60.0%(12/20), respectively, among them, the differences of the positive rates were statistically significant (P < 0.01). "
07/01/2001 - "Specific kinase activity of the proto-oncogene product pp60(c-src) is reported to be elevated in patients with carcinoma of the colon, and a novel cytoplasmic protein-tyrosine kinase, C-terminal Src kinase (Csk), has been found to inactivate the members of the Src family protein-tyrosine kinase. "
4. Neoplasm Metastasis (Metastasis)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Protein-Tyrosine Kinases (Tyrosine Kinase)
2. Phosphotransferases (Kinase)
3. Proteins (Proteins, Gene)
4. Tyrosine (L-Tyrosine)
5. Focal Adhesion Kinase 2
6. Focal Adhesion Protein-Tyrosine Kinases
7. beta Catenin
8. Small Interfering RNA (siRNA)
9. Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
10. Plasminogen Activator Inhibitor 1

Related Therapies and Procedures

1. Therapeutics