Antisense RNA (Anti-Sense RNA)

RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes.

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Networked: 468 relevant articles (10 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Wei: 7 articles (08/2013 - 04/2006)
2.	Ma, Ding: 4 articles (08/2007 - 04/2006)
3.	Yu, Min: 4 articles (10/2006 - 03/2002)
4.	Li, Hui: 3 articles (01/2015 - 03/2010)
5.	Li, Wei: 3 articles (06/2010 - 04/2005)
6.	Prada, Federico: 3 articles (04/2008 - 06/2005)
7.	Salvatierra, Edgardo: 3 articles (04/2008 - 06/2005)
8.	Sima, Ni: 3 articles (08/2007 - 01/2007)
9.	Friedrich, Inbar: 3 articles (11/2005 - 08/2004)
10.	Levitzki, Alexander: 3 articles (11/2005 - 08/2004)

Related Diseases

1.	Neoplasms (Cancer) 11/11/1999 - "The clones expressing AR antisense RNA showed a reversion of the malignant phenotype when injected in nude mice, since a significant reduction of tumor intake was observed coincident with a significant tumor mass reduction (> 96%). " 07/01/2014 - "In our study, we selected ABHD11 Antisense RNA 1 (ABHD11-AS1) as a representative lncRNAs to study the different expression levels between gastric tumor and adjacent non-tumor tissues. " 01/01/2007 - "This study was to investigate the effects of HPV16 E6E7 antisense RNA on the expression of oncogene E6 and E7 and apoptosis of human cervical cancer cell line SiHa harboring HPV16 genome. " 06/01/2005 - "In the present study, we inhibited the expression of GATA-3 in tumor cells through antisense RNA blockade technique, and observed its effects on tumor in vitro and in vivo. " 10/09/1997 - "This study demonstrates that antisense RNA can increase the sensitivity of tumor cells to anticancer drug by decreasing the expression of the MDR1 gene. "
2.	Infection 11/15/2007 - "In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics." 06/15/1996 - "Long-term protection against HIV-1 infection conferred by tat or rev antisense RNA was affected by the design of the retroviral vector." 06/01/1995 - "In the present study, we examined the inhibitory effects of an antisense RNA on viral multiplication in chronic MHV infection. " 08/01/1993 - "The results of the present study show the ability of antisense RNA against the viral gene to protect against viral infection in vivo." 09/10/2013 - "Inhibition of CXCR4 expression by recombinant adenoviruses containing anti-sense RNA resists HIV-1 infection on MT4 cell lines."
3.	Hepatocellular Carcinoma (Hepatoma) 10/01/2003 - "To study the inhibitory effects of antisense RNA of HAb18G/CD147 on invasion of hepatocellular carcinoma(HCC) cells in vitro. " 01/01/2014 - "We previously found that HOX transcript antisense RNA (HOTAIR) is a negative prognostic factor and exhibits oncogenic activity in hepatocellular carcinoma (HCC). " 01/01/2011 - "In this observational retrospective study, the expression of the oncogenic lincRNA HOX transcript antisense RNA (HOTAIR) gene was measured in 63 patients with hepatocellular carcinoma (HCC) following hepatic resection. " 08/01/2007 - "In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinoma cells." 07/01/2007 - "System ASC amino acid transporter-2 (ASCT2) was previously demonstrated to be essential for human hepatoma cell growth and survival, as its silencing via inducible antisense RNA expression results in complete apoptosis within 48 h by a mechanism that transcends its role in amino acid delivery. "
4.	Wounds and Injuries (Trauma) 01/01/2003 - "Using in situ hybridization with DIG-labeled anti-sense RNA probe, the expression of FN EDA\EDB domain was detected in human skin incised wound at the early stage of injury (from 30 min to 3 h). " 02/01/2002 - "Using in situ hybridization with DIG-labeled anti-sense RNA probe, the expression of FN-IIIcs domain was detected in both human and rat skin incised wound. " 09/01/1997 - "In situ hybridization experiments using transgene-specific 35S-labeled antisense RNA probes localized transgene expression to the basal epidermal cells in wound-induced papillomas. " 07/01/2007 - "To validate and probe the functional significance of ERG in leukocytes, we developed an infected wound model of inflammation in zebrafish and assessed the efficacy of two ERG-specific inhibitors, dofetilide and E4031, as well as an ERG-specific antisense RNA morpholino on neutrophil recruitment. " 07/01/1994 - "The authors used a radiolabeled RNA antisense probe, complementary to the mRNA for the alpha-1 chain of human procollagen type I, to assess regulation of this collagen species in fetal and adult rabbit wounds. "
5.	HIV Infections (HIV Infection) 06/15/1998 - "Moreover, HIV infection was significantly reduced in the clones expressing CD26 anti-sense RNA. " 06/15/1998 - "For this purpose, CEM T cells, which are permissive to HIV infection and express low levels of CD26, were used to establish by transfection four groups of cell clones expressing either low, high, and very high levels of CD26, or expressing the anti-sense RNA of CD26. " 10/01/1997 - "Different cell lines and PBLs were transduced by retroviral vectors producing antisense RNA and were then challenged by HIV infection. " 02/01/1991 - "Antisense RNA to treat HIV infections." 06/15/1996 - "Our results demonstrated that antisense RNA expression driven by tRNA promoter in the context of a double-copy vector conferred better long-term protection against HIV infection compared to that driven by HIV LTR or MLV LTR promoters, and that the optimized vectors may be useful in developing a gene therapy against HIV-1 infection and AIDS."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Small Interfering RNA (siRNA)
3.	Oligonucleotides
4.	Insulin-Like Growth Factor I (IGF-1)
5.	Catalytic RNA (Ribozymes)
6.	Spliced Leader RNA (Spliced Leader)
7.	Transfer RNA (tRNA)
8.	Doxorubicin (Adriamycin)
9.	dofetilide (Tikosyn)
10.	intrinsic factor-cobalamin receptor

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Lasers (Laser)
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Radiotherapy