Ethylketocyclazocine

A kappa opioid receptor agonist. The compound has analgesic action and shows positive inotropic effects on the electrically stimulated left atrium. It also affects various types of behavior in mammals such as locomotion, rearing, and grooming.

Also Known As:

Networked: 39 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bakogeorgou, Efstathia: 1 article (05/2008)
2.	Castanas, Elias: 1 article (05/2008)
3.	Dimitriou, Helen: 1 article (05/2008)
4.	Hatzoglou, Anastassia: 1 article (05/2008)
5.	Kampa, Marilena: 1 article (05/2008)
6.	Vassou, Despoina: 1 article (05/2008)
7.	Bergman, Jack: 1 article (12/2007)
8.	Gilman, Joanne P: 1 article (12/2007)
9.	Goldberg, Steven R: 1 article (12/2007)
10.	Graczyk, Zofi: 1 article (12/2007)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 05/01/1999 - "In the present work, we have examined the effect of two general opioid agonists (ethylketocyclazocine and etorphine) on the cell cycle, in human breast cancer T47D cells, as well as a possible modification of the cellular cytoskeleton under their action, in order to explain the antiproliferative effect of these agents. " 06/09/1997 - "In the T47D human breast cancer cell line, Taxol was found to compete for ethylketocyclazocine opioid binding (IC50 3.3 pM). " 08/29/1996 - "In previous studies, we have shown that opioid agonists ([D-Ala2, D-Leu5]enkephalin (DADLE), [D-Ser2, Leu5]enkephalin-Thr6 (DSLET), ethylketocyclazocine and etorphine) bind to opioid binding sites and decrease cell proliferation of human T47D breast cancer cells. "
2.	Hyperphagia (Overeating) 10/01/1985 - "Thus, hyperphagia occurred with 0.01 mg/kg bremazocine and 0.1 mg/kg ethylketocyclazocine. " 01/01/1988 - "The present study compared naloxone and naloxonazine antagonism of hyperphagia induced by morphine, ethylketocyclazocine (EKC), dynorphin and d-ala2,d-leu5-enkephalin (DADL) in rats. "
3.	Multiple Myeloma 05/01/2008 - "The aim of the present study was to investigate whether opioid agonists (morphine, alpha(S1)-casomorphin and ethylketocyclazocine) may have a direct action on the secretion of antibodies and cytokines by multiple myeloma-derived cell lines and normal CD19+ B-lymphocytes. "
4.	Cardiac Arrhythmias (Arrythmia) 01/01/1993 - "The purpose of this study was to determine whether the opioid receptor agonist ethylketocyclazocine (EKC) modulates the development of cardiac arrhythmias by an action within the central nervous system. " 01/01/1993 - "The opioid agonist ethylketocyclazocine accentuates epinephrine-induced cardiac arrhythmias in the rat through an action in the brain."
5.	Shock 11/01/1986 - "Ethylketazocine was 30 to 100 times more potent than morphine under either the schedule of food or shock presentation in squirrel monkeys, whereas the two drugs had similar potencies in pigeons. " 11/01/1986 - "The behavioral effects of morphine and ethylketazocine were compared in squirrel monkeys and pigeons responding under fixed-interval schedules of food presentation, and in monkeys responding under fixed-interval schedules of electric-shock presentation. " 10/14/1983 - "The effects of two putative kappa agonists, ketocyclazocine and ethylketocyclazocine, on electric shock titration in squirrel monkeys were determined. " 10/14/1983 - "Effects of ketocyclazocine and ethylketocyclazocine on electric shock titration." 01/01/1983 - "Ethylketocyclazocine may act as an antagonist at the epsilon opiate receptor, indicating possible involvement of this receptor type in the pathogenesis of circulatory shock."

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Opioid Analgesics (Opioids)
3.	Enkephalins
4.	Etorphine (M99)
5.	Leucine-2-Alanine Enkephalin (Enkephalin, Leucine 2 Alanine)
6.	Opioid Receptors (Opioid Receptor)
7.	Naloxone (Narcan)
8.	Thr(6)- Leu(5) Ser(2) enkephalin
9.	Cytokines
10.	Dynorphins (Dynorphin)

Related Therapies and Procedures

1.	Intra-Arterial Infusions