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Leucine-2-Alanine Enkephalin (Enkephalin, Leucine 2 Alanine)

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A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

Also Known As:

Enkephalin, Leucine 2 Alanine; Enkephalin, Leucine-2-Alanine; BW-180C; DADLE; Leu-Enkephalin-2-Ala; 2 Alanyl Leucine Enkephalin; 5 Leucine 2 Alanine Enkephalin; BW 180C; BW180C; Enkephalin, 2-Alanyl-Leucine; Enkephalin, 5-Leucine-2-Alanine; Enkephalin-2-Alanine, Leucine; Leu Enkephalin 2 Ala; Leucine Enkephalin 2 Alanine; 2-Alanyl-Leucine Enkephalin; 5-Leucine-2-Alanine Enkephalin; D-Ala(2)-D-Leu(5)-Enkephalin; Enkephalin-Leu,Ala(2); Leucine Enkephalin-2-Alanine; D-Leucine, N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-

Networked: 103 relevant articles (6 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Peptides: 22950
  - Opioid Peptides: 1161
    - Enkephalins: 931
      - Leucine Enkephalin: 280
        Leucine-2-Alanine Enkephalin: 103
        Ala(2)-Arg(6)- enkephalin-Leu: 142
        Ala(2)-Cys(6)- enkephalin-Leu: 5
        Ala(2)-Ser(6)- enkephalin-Leu: 5
        Ala(2)-aminoethyl dimer- enkephalinamide-Leu: 2
        destyrosyl- dalargin: 2
        Ala(2)-N-(2-((4-azido-2-nitrophenyl)amino)N-ethyl(5))- enkephalinamide-Leu: 1
        de-Tyr(1)-Ala(2)- enkephalinamide-Leu: 1
        (Ala(2)-Cl-Phe(4))- enkephalin-Leu
        2-Ala-5-N-Et-Leu-enkephalinamide
        Ala(2)- enkephalin-Leu-polyethylene glycol
        Ala(2)- enkephalinamide-Leu
        Ala(2)-(cyclopropyl-Phe)(4)- enkephalin-Leu
        Ala(2)-cyclopropyl-Phe(4)- enkephalin-Leu methyl ester
        Ala(2)-cystamine-dimer- enkephalin-Leu
        Ala(2)-Me-Phe(4)- enkephalin-Leu
        Ala(2)-melphalan methyl ester- enkephalin-Leu
        azoenkephalin
        N,N-diallyl-Ala(2)- enkephalin-Leu
        N,N-diallyl-Ala(2)-bis(cystine)(6)- enkephalin-Leu
        tyrosyl-alanyl-glycyl-phenylalanyl-psi(thiomethylene)leucine

Experts

1.	Su, T P: 5 articles (11/2001 - 04/2000)
2.	Tanno, Masaya: 3 articles (06/2012 - 09/2006)
3.	Miura, Tetsuji: 3 articles (06/2012 - 09/2006)
4.	Miki, Takayuki: 3 articles (06/2012 - 09/2006)
5.	Xia, Ying: 3 articles (11/2011 - 04/2006)
6.	Krieg, Thomas: 3 articles (07/2010 - 03/2004)
7.	Su, Tsung-Ping: 3 articles (01/2009 - 01/2002)
8.	Wang, Y: 3 articles (03/2001 - 04/2000)
9.	Tang, Bo: 2 articles (09/2015 - 06/2012)
10.	Kuno, Atsushi: 2 articles (06/2012 - 09/2007)

Related Diseases

1.	Ischemia 09/01/2015 - "Previous studies have demonstrated that (D‑Ala2, D‑Leu5)‑enkephalin (DADLE) protects rats from hepatic ischemia/reperfusion (I/R) injury. " 08/16/2007 - "We found in our study that administration of DADLE 45 min before forebrain ischemia had significant protective effect against CA1 neuronal lose. " 08/16/2007 - "This study was aimed to investigate whether intracerebroventricular (ICV) administration of DADLE has a neuroprotective effect against forebrain ischemia in rats. " 01/01/2015 - "These results suggested that DADLE infused into the abdominal aorta during ischemia period could attenuate behavioral retardation and the loss of normal motor neuron induced by ischemia-reperfusion in rabbits." 01/01/2015 - "Here we investigate whether DADLE could attenuate ischemia and reperfusion induced neural injury in the rabbit spinal cord. "
2.	Seizures (Seizure) 08/01/1992 - "Systemic or intracisternal injection of both morphine and DADLE decreased the incidence of seizures and the seizure score in El mice in a dose-dependent manner. " 08/12/1985 - "The results of this study demonstrated that the effects of DADLE to increase seizure threshold in the rat were primarily mediated by activation of a delta-opioid receptor system. " 02/01/1987 - "Behaviorally, the DAGO and DADLE EEG seizures were nonconvulsive but were temporally associated with episodic bursts of wet-dog shakes. " 02/01/1987 - "DAGO produced a greater number of seizure episodes with a greater overall incidence compared with DADLE, reflecting its potent effect to elicit EEG seizure activity in these rats. " 02/01/1987 - "Only DAGO and DADLE were found to produce EEG seizures, with DAGO being 9 times more potent than DADLE. "
3.	Reperfusion Injury 05/11/2011 - "The results showed that DADLE at doses of 0.25 and 2.5 nmol, but not 25 nmol, could significantly protect CA1 neurons against ischemia/reperfusion injury. " 01/01/2009 - "These results indicate that DADLE protected against necrotic and apoptotic cell death processes associated with ischemia-reperfusion injury. " 06/01/2002 - "Most notably, mesenteric ischemia/reperfusion injury was attenuated by DADLE: reperfusion contractile force was 47 +/- 5% versus 36 +/- 5% in DADLE-treated versus control segments (p < 0.01). " 05/01/2008 - "The delta opioid agonist DADLE ([D-Ala(2),D-Leu(5)]-enkephalin) was shown previously to be protective against ischemia-reperfusion injury in multiple organs, including brain. " 09/01/2003 - "[D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat."
4.	Hemorrhagic Shock 06/01/2003 - "In an animal model of severe hemorrhagic shock, there was improvement in hemodynamic stability and a prolonged survival with DADLE treatment. " 06/01/2003 - "The coordinated various actions of DADLE have the potential to work in concert in the intact organism to improve overall survival during severe hemorrhagic shock. " 04/01/1994 - "The results were as follows: 1) there was no dramatic difference between the 2-15 Hz ET group and the control group in the recovery of MAP and HR from hemorrhagic shock; 2) DADLE (25 micrograms) caused almost the same depressor effect in the 2 Hz ET group as that in the control group. " 01/01/1992 - "Then, we observed: (1) The effect of 2-15Hz ET on the recovery of mean arterial blood pressure (MAP) and heart rate (HR) of rats after hemorrhagic shock; (2) The change in MAP and HR of rats subjected to 2Hz ET after intrathecally (i. t.) administration of DADLE 25 micrograms, a delta opioid agonist. " 06/01/2003 - "The authors examined the effect of the nonselective delta receptor agonist, DADLE (D-Ala2-Leu5-enkephalin), on hemodynamic stability and duration of survival in an animal model of severe hemorrhagic shock. "
5.	Pain (Aches) 03/13/1986 - "These results show that pain-inducing BK has a major acute stimulatory effect on receptor-phospholipase C-coupled IP3 release, the opioid peptide DADLE has no such effect and, DADLE does not block the IP3 release induced by BK." 07/01/1990 - "The basal difference in action of the studied drugs was that nootropics (phenybut in a dose of 40 mg/kg and pyracetam in a dose of 200-400 mg/kg) did not change the initial action of pain reinforcement on synchronism in responses of the cortical neurones of alert nonimmobilized rabbits by inhibitory type (coincidence of the presence and absence of impulse activity) towards its decrease, while narcotics of various types (ethanol in a dose of 4-6 mg/kg, morphine-like opiate DAGO and opioid peptide DADLE in doses of 250 mkg/kg) eliminated the action of pain reinforcement on synchronism in responses of the cortical neurones both by inhibitory and activation (time of coincidence only of the presence of impulse activity) types. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
3.	Enkephalins
4.	Opioid Peptides (Opioid Peptide)
5.	Protein Kinase C-epsilon
6.	Nootropic Agents (Nootropics)
7.	Piracetam (Nootropil)
8.	Narcotics (Narcotic Analgesics)
9.	Ethanol (Ethyl Alcohol)
10.	rottlerin

Related Therapies and Procedures

1.	Resuscitation
2.	Catheters
3.	Intravenous Infusions
4.	Transplantation (Transplant Recipients)
5.	Intraperitoneal Injections