Thymopentin

Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.

Also Known As:

Networked: 164 relevant articles (22 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Khrenov, M O: 3 articles (03/2013 - 07/2008)
2.	Novoselova, E G: 3 articles (03/2013 - 07/2008)
3.	Lunin, S M: 3 articles (03/2013 - 07/2008)
4.	Fesenko, E E: 3 articles (03/2013 - 07/2008)
5.	Novoselova, T V: 3 articles (03/2013 - 07/2008)
6.	Glushkova, O V: 2 articles (03/2013 - 03/2009)
7.	Zhao, Dawei: 1 article (04/2015)
8.	Zhao, Fei: 1 article (04/2015)
9.	Zhang, Helong: 1 article (04/2015)
10.	Wang, Shuhong: 1 article (04/2015)

Related Diseases

1.	Rheumatoid Arthritis 04/01/1989 - "TP-5 is a potentially useful agent in the treatment of rheumatoid arthritis, although further studies are required to determine the optimal treatment regimen." 04/01/1989 - "A randomized control trial of TP-5 in rheumatoid arthritis is reported. " 02/05/1988 - "In a multicenter, placebo-controlled and randomized double-blind trial 119 patients with rheumatoid arthritis were treated with thymopentin, an immunoregulating drug. " 01/01/1985 - "Confirmative study of the effectiveness of thymopentin in active rheumatoid arthritis." 02/29/1980 - "Effects of thymopoietin pentapeptide on low reversible E-rosette forming cells of rheumatoid arthritis patients.-II) In vivo study."
2.	Infection 12/01/1993 - "In conclusion, thymopentin, administered subcutaneous for 5 weeks in winter, may be useful in the treatment of children with recurrent infections of the respiratory tract." 01/01/1989 - "[Recurrent infections of the urogenital tract: preliminary results of a study on the clinical and immunological effects of thymopentin treatment]." 11/01/1999 - "Thymopentin and some of the analogs were found to stimulate nonspecific resistance of the host against Leishmania donovani infection in hamsters." 11/01/1999 - "Stimulation of nonspecific resistance by thymopentin and its analogs against Leishmania donovani infection in hamsters." 06/01/1995 - "[Thymopentin and cervico-vaginal HPV infection associated with CIN]."
3.	Pain (Aches) 01/01/1985 - "The intergroup comparison showed statistically significant differences, favoring thymopentin over placebo treatment, in the Ritchie index, the scores of swollen joints, the assessment of severity of pain, and the scores for changes in the activity of the disease. " 01/01/1988 - "Intergroup comparison on completion of the therapy with regard to the criteria "pain at rest", "pain on pressure", "disability of articulation", and "pain relief" revealed statistically significant superiority of thymopentin. " 04/13/1985 - "The intergroup comparisons showed that thymopentin was significantly better than placebo in reducing tenderness, joint swelling, severity of pain on awakening, and disease activity. " 01/01/1984 - "The intergroup comparison showed significant differences, favouring thymopentin over placebo treatment, in the Ritchie index, scores for swollen joints, assessment of severity of pain and scores for changes in the activity of the disease. " 01/01/1984 - "Most of the symptoms, particularly pain, capsular swelling, tenderness and morning stiffness, were remarkably reduced within 3 weeks of thymopentin treatment. "
4.	Chronic Bronchitis 02/28/1990 - "The design of the present study permits to analyse the efficacy of thymopentin treatment in seasonal prophylaxis of chronic bronchitis in elderly patients. " 01/01/1990 - "[A clinico-epidemiological study on the efficacy of thymopentin therapy in patients with chronic bronchitis and cellular immunity deficiency]." 01/01/1992 - "[Aerosol thymopentin in the prevention of relapse of chronic bronchitis]." 01/01/1990 - "The immunological in vivo effects of thymopentin (TP5) treatment in eleven hypo-anergic patients affected with chronic bronchitis are reported. "
5.	Atopic Dermatitis (Atopic Eczema) 05/01/1990 - "We conclude that treatment with thymopentin is safe and offers significant therapeutic promise for atopic dermatitis." 04/01/1994 - "A double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of thymopentin as an adjunctive treatment in atopic dermatitis." 04/01/1994 - "Thymopentin may be a safe effective adjunct to therapy in patients with severe atopic dermatitis." 09/01/1992 - "An open clinical trial of thymopentin was conducted on 16 children with severe atopic dermatitis. " 09/01/1992 - "Thymopentin treatment in severe atopic dermatitis--clinical and immunological evaluations."

Related Drugs and Biologics

1.	Thymopentin
2.	Interleukin-2 (IL2)
3.	Fluorouracil (Carac)
4.	Interferon-alpha (Interferon Alfa)
5.	Interferon-gamma (Interferon, gamma)
6.	Immunoglobulin E (IgE)
7.	Antigens
8.	Insulin (Novolin)
9.	Secretory Immunoglobulin A (SIgA)
10.	HLA-DR Antigens (HLA-DR)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Intravenous Injections
4.	Nutritional Support (Artificial Feeding)
5.	Splenectomy