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Alveolar Bone Loss

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Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.

Also Known As:

Alveolar Bone Atrophy; Alveolar Process Atrophy; Alveolar Bone Atrophies; Alveolar Bone Losses; Alveolar Process Atrophies; Alveolar Resorptions; Bone Atrophies, Alveolar; Bone Atrophy, Alveolar; Bone Losses, Periodontal; Periodontal Bone Losses; Periodontal Resorptions; Resorption, Alveolar; Resorption, Periodontal; Resorptions, Alveolar; Alveolar Resorption; Bone Loss, Alveolar; Bone Loss, Periodontal; Periodontal Bone Loss; Periodontal Resorption

Networked: 592 relevant articles (47 outcomes, 128 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Periodontitis
2.	Periodontal Diseases (Periodontal Disease)
3.	Inflammation
4.	Infection
5.	Body Weight (Weight, Body)

Experts

1.	Rösing, Cassiano Kuchenbecker: 7 articles (11/2012 - 10/2003)
2.	Spolidorio, L C: 6 articles (12/2014 - 06/2004)
3.	Gaio, Eduardo José: 6 articles (11/2012 - 10/2005)
4.	Ekuni, Daisuke: 5 articles (01/2013 - 04/2009)
5.	Holzhausen, Marinella: 5 articles (12/2011 - 09/2002)
6.	Nociti, F H: 5 articles (10/2011 - 09/2000)
7.	Hajishengallis, George: 4 articles (08/2015 - 03/2014)
8.	Li, Y: 4 articles (02/2015 - 10/2013)
9.	Kirkwood, K L: 4 articles (02/2015 - 03/2014)
10.	Spolidorio, Luis Carlos: 4 articles (01/2015 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alveolar Bone Loss:

1.	Simvastatin (Zocor)FDA LinkGeneric 10/01/2014 - "Furthermore, simvastatin improved the blood lipid profile and reduced alveolar bone loss. " 08/01/2013 - "Treatment with simvastatin improved alveolar bone loss within all of the parameters studied, thus demonstrating anti-inflammatory and antioxidant activity. " 03/01/2014 - "Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome." 01/01/2014 - "Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. " 06/01/2008 - "These findings demonstrate that simvastatin has the potential to stimulate osteoblastic function and that topical administration of simvastatin may be effective for the recovery of alveolar bone loss in rats."
2.	Alendronate (Alendronate Sodium)FDA LinkGeneric 09/01/2003 - "The systemic administration of 0.5 mg/kg alendronate was effective in preventing alveolar bone loss and in modulating tissue factors. " 10/01/2000 - "We conclude that ISA-13-like alendronate is effective in reducing alveolar bone loss when delivered at surgical sites. " 08/01/2000 - "In the present study, we explored the effectiveness of different concentrations of alendronate, delivered at the surgical site at the time of surgery, in distant delivery in reducing alveolar bone loss. " 10/01/2000 - "We have established that topical application of 20 mg/ml of alendronate placed at the surgical mucoperiosteal site produced a striking reduction of alveolar bone loss in the rat model. " 08/01/2000 - "Alendronate given intravenously significantly reduced alveolar bone loss in mucoperiosteal flap procedures. "
3.	CollagenIBA 12/01/2015 - "Micro-computed tomography and sirius red staining were used to evaluate alveolar bone loss and collagen destruction, respectively. " 11/01/2015 - "Regardless of the reduction of the expression of Il1b, Nos2, and Mmp9, the drugs were not effective in the stabilization or reduction of alveolar bone loss and collagen degradation in rats." 02/01/2013 - "The novel ELP-collagen composite material may have future implications as a scaffold material for bone tissue engineering applications, for example, the treatment of alveolar bone loss." 05/01/2008 - "The alveolar bone loss (ABL) and the area fraction (AA% ) occupied by collagen fibers were assessed. " 02/01/2008 - "The alveolar bone loss and the area fraction occupied by collagen fibers were assessed. "
4.	Interleukin-10 (Interleukin 10)IBA 08/01/2003 - "Interleukin-10(-/-) mice had significantly greater alveolar bone loss than interleukin-10(+/+) mice (p = 0.006). " 12/01/2004 - "In the present study, we tested the hypothesis that endogenous interleukin-10 is a potent suppressor of Porphyromonas gingivalis-induced alveolar bone loss in vivo. " 08/01/2003 - "The results of the present study suggest that lack of interleukin-10 leads to accelerated alveolar bone loss." 12/01/2012 - "A distinct systemic response in vivo was observed among different strains of P. gingivalis, with IL-10 associated with the least amount of alveolar bone loss. " 02/01/2010 - "Our results demonstrate that the alveolar bone loss in the absence of IL-10 was associated with a reduced expression of osteoblast and osteocyte markers, an effect independent of microbial, inflammatory or bone-resorptive pathways."
5.	Dental Implants (Dental Implant)IBA 03/01/2011 - "The present findings suggest that local levels of ICTP and OPG reflect an increased risk of alveolar bone loss around dental implants, and their local levels may help to distinguish diseased and healthy sites." 01/01/2013 - "The study included 56 patients with partial and full teeth loss and significant alveolar bone atrophy Resonance frequency rates were used to assess intraosseous dental implants stability showing its improvement after alveolar bone augmentation procedures." 01/01/2013 - "The use of osteoplastic materials allows extending indications for dental implants placement by considerable alveolar bone atrophy. " 10/01/2011 - "Dental implants have played a part in rehabilitation of the jaws for more than 40 years, but in some cases they alone are inadequate because of extreme alveolar resorption. " 11/01/2008 - "Severe alveolar bone loss affects dental implant placement. "
6.	DiphosphonatesIBA 06/01/2011 - "Influence of bisphosphonates on alveolar bone loss around osseointegrated implants." 07/01/1987 - "The effects of diphosphonates on alveolar bone loss." 06/01/2001 - "Future studies of the effect of bisphosphonates on the jaw BMC and alveolar bone loss, and analyses of the bone quality and jaw BMC/BMD in relation to implant treatment, without or with bone transplantation, are required." 07/01/2007 - "Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis." 07/01/2003 - "Recent animal studies have shown that a combination of chemically-modified tetracyclines together with bisphosphonates, when delivered systemically, are synergistically effective in suppressing periodontal bone loss. "
7.	Interleukin-17 (Interleukin 27)IBA 01/01/2008 - "Ablation of IL-17 signaling prior to onset of infection with Porphyromonas gingivalis increases susceptibility to periodontal bone loss, but this finding does not rule out the efficacy of therapeutic inhibition of IL-17 after onset of severe disease. " 01/01/2013 - "In periodontal lesions, IL-17 levels are significantly greater than IL-4, which plays a protective role against alveolar bone loss." 03/26/2014 - "Local treatment with antibodies to IL-17 or IL-23 in LFA-1-deficient mice not only blocked inflammatory periodontal bone loss but also caused a reduction in the total bacterial burden, suggesting that the IL-17-driven pathogenesis of LAD-I periodontitis leads to dysbiosis. " 08/01/2010 - "In comparison with young mice, old mice displayed significantly (p < 0.05) increased periodontal bone loss, accompanied by elevated expression of proinflammatory cytokines (interleukin-1 beta, tumor necrosis factor alpha and interleukin-17A) and innate immune receptors involved in the induction or amplification of inflammation (Toll-like receptor 2, CD14, CD11b, CD18, complement C5a receptor and triggering receptor expressed on myeloid cells 3). "
8.	Doxycycline (Vibramycin)FDA LinkGeneric 06/01/2000 - "The purpose of this study was to observe the effect of systemic Doxycycline on crestal alveolar bone loss after periradicular surgery in beagle dogs. " 09/01/2007 - "Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women." 06/01/2000 - "Effect of systemic doxycycline on alveolar bone loss after periradicular surgery." 07/01/2010 - "The aim of this study was to test the efficacy of a locally applied 8.5% nanostructured doxycycline (DOX) gel in preventing alveolar bone loss in experimental periodontal disease (EPD) in rats by using the tapping mode atomic force microscopy (AFM). " 03/01/2014 - "Effect of low-dose doxycycline on serum oxidative status, gingival antioxidant levels, and alveolar bone loss in experimental periodontitis in rats."
9.	Cyclosporine (Ciclosporin)FDA LinkGeneric 08/01/2009 - "Cyclosporine A treatment is important in the therapy of a number of medical conditions; however, alveolar bone loss is an important negative side-effect of this drug. " 06/01/2004 - "On the other hand, the radiographic data showed that cyclosporin A therapy diminished the alveolar bone loss at the mesial surface of the lower first molars. " 01/01/2012 - "Cyclosporine can cause alveolar bone loss and osteopenia. " 10/01/2007 - "As we have shown that cyclosporine A-associated bone loss can also affect the alveolar bone, the purpose of this study was to evaluate the effect of the concomitant administration of alendronate on alveolar bone loss in a rat model. " 08/01/2009 - "Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats."
10.	TetracyclinesIBA 07/01/2003 - "In the present study, we found that tetracyclines can be most effective in reducing alveolar bone loss when applied locally. " 07/01/1994 - "The current study was undertaken to determine whether tetracyclines can inhibit alveolar bone loss in vivo due to a non-antimicrobial action of these drugs. " 07/01/2002 - "Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines." 07/01/1994 - "Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism." 07/01/2003 - "Recent animal studies have shown that a combination of chemically-modified tetracyclines together with bisphosphonates, when delivered systemically, are synergistically effective in suppressing periodontal bone loss. "

Therapies and Procedures

1.	Ligation 11/15/2006 - "In vivo studies revealed that ligature-induced periodontal bone loss is significantly greater in Akita mice compared with WT. Moreover, intravital microscopy of gingival vessels showed that leukocyte rolling and attachment to the vascular endothelium is enhanced in periodontal vessels of Akita mice. " 02/01/2014 - "This study aimed to evaluate the effects of the combination of ALD and ATV on ligature-induced alveolar bone loss in rats. " 01/01/2014 - "The aim of the present study was to assess the impact of chronic consumption of Cachaça on alveolar bone loss (BL) induced by ligature and on alveolar bone density (BD) in peripubertal rats. " 10/01/2011 - "The aim of this study was to evaluate the impact of Porphyromonas gingivalis inoculation on the ligature-induced alveolar bone loss (ABL) model in rats. " 02/01/2011 - "The results of this study lead to the conclusion that low concentration alcohol intake did not affect the alveolar bone loss in ligature induced periodontal breakdown."
2.	Aftercare (After-Treatment) 11/01/2012 - "Furthermore, no problems related to anchorage or alveolar bone loss were identified after treatment. " 12/01/2000 - "gingivalis in plaque after treatment might be indicative of progressive alveolar bone loss." 12/01/2000 - "Progressive alveolar bone loss was determined using digital subtraction radiography with standardized radiographs taken at baseline and 6 months after treatment. " 09/01/2002 - " mean HGF content in GCF from sites with clinically healthy gingiva, defined by the absence of overt signs of gingival inflammation and a probing depth (PD) <3 mm, was 1.7 ng/ml, and that of periodontitis, defined by obvious alveolar bone loss detected by radiographic examination and a PD> or =3 mm, was 3.23 ng/ml. Although treating the periodontitis did not significantly decrease the HGF concentration despite significantly improved clinical scores such as PD and Gingival Index, the total amount of HGF in GCF did decrease significantly after treatment. " 04/01/2009 - "Probing pocket depth (PPD), percentage of alveolar bone loss, presence of tooth mobility and bleeding on probing in all teeth improved significantly after treatment. "
3.	Complete Denture (Dentures, Complete) 09/01/2003 - "The aim of this study was to establish if smoking affects alveolar bone loss in complete denture wearers. " 03/01/1994 - "A 4-year cephalometric study was conducted on 14 wearers of complete dentures to quantify the anterior alveolar bone loss and to study any associated changes in the maxillomandibular relationships. " 09/01/2003 - "Excessive alveolar bone atrophy often confounds a conventional therapy with complete dentures. " 08/01/1992 - "Due to extreme alveolar resorption many edentulous patients wearing complete dentures suffer from loss of function of the orofacial system. " 01/01/1983 - "[Complete denture for cases with marked alveolar resorption]."
4.	Ovariectomy (Oophorectomy) 01/01/2015 - "These experiments revealed that RDE could inhibit ovariectomy-induced alveolar bone loss in rats. " 12/01/2014 - "These experiments revealed that RDE could inhibit ovariectomy-induced alveolar bone loss in rats. " 09/01/1997 - "Alveolar bone loss one year following ovariectomy in sheep." 09/01/2015 - "The results of the present study showed that ovariectomy enhanced alveolar bone loss and reduced the ACH of rats with experimental periodontitis. " 04/01/2002 - "These compounds may also be effective in preventing bone loss associated with hypodynamia or immobility, ovariectomy or postmenopausal hypoestrogenia, chronic corticosteroid use, renal osteodystrophy, hyperparathyroidism and other metabolic disorders affecting the calcified tissues, including alveolar bone loss in periodontal disease as well as dental hard tissues destruction."
5.	Transplants (Transplant) 10/01/2015 - "In cases of severe alveolar bone atrophy in the posterior maxillary area, which has only a thin sinus floor, the autogenous tooth bone graft block (ABTB) was used to wrap the implant to enhance its primary stability and osseointegration in the sinus. " 01/01/2014 - " main indication was the case of severe alveolar resorption in 21 cases (72.41%), followed by failures in maxillary reconstruction with bone graft in 4 (13.79%). " 08/01/2001 - "Subperiosteal connective tissue grafts were placed in 2 sites of periodontal bone loss and deep pocketing in one patient. " 11/01/2000 - "The mandibular ramus/body grafts remained viable regardless of the age or the extent of alveolar resorption in the patients treated. " 04/01/1992 - "Small bone defects due to atrophic, traumatic or periodontal bone loss can be grafted with autologous bone grafts taken from the maxillary tuberosity. "