Dextran Sulfate

Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.

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Networked: 1592 relevant articles (126 outcomes, 305 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fujiyama, Yoshihide: 18 articles (01/2013 - 04/2002)
2.	Andoh, Akira: 15 articles (01/2013 - 04/2002)
3.	Araki, Yoshio: 15 articles (11/2012 - 04/2002)
4.	Kim, Joo Sung: 13 articles (12/2015 - 02/2007)
5.	Tanaka, Takuji: 13 articles (05/2015 - 02/2005)
6.	Naito, Yuji: 12 articles (09/2013 - 01/2002)
7.	Yoshikawa, Toshikazu: 11 articles (09/2013 - 01/2002)
8.	Takagi, Tomohisa: 10 articles (09/2013 - 01/2002)
9.	Howarth, Gordon S: 10 articles (05/2012 - 04/2005)
10.	Ghia, Jean-Eric: 9 articles (06/2014 - 03/2008)

Related Diseases

1.	Colitis 05/01/2002 - "In conclusion, exogenous NO supplementation significantly ameliorates dextran sulfate sodium-induced colitis. " 11/01/2012 - "Here, we focus on the therapeutic efficacy of IL-1β-primed MSCs in the dextran sulfate sodium (DSS)-induced colitis model, in addition to the underlining mechanisms. " 11/01/2012 - "STW 5 is effective in dextran sulfate sodium-induced colitis in rats." 10/01/2005 - "The therapeutic value of SOD1 when administered prophylactically was assessed in the dextran sulfate sodium model of colitis with similar positive results. " 10/01/2002 - "Repeated colitis was induced by nine administration cycles of 3% dextran sulfate sodium (DSS; molecular weight, 54 000): each administration cycle comprised 3% DSS for 7 days followed by distilled water for the subsequent 14 days, to give conditions similar to the clinically observed active and remission phases in humans. "
2.	Inflammation 01/01/2011 - "Daily intrarectal administration of poly P (10 µg) improved the inflammation grade and survival rate in 4% sodium dextran sulfate-administered mice. " 05/01/1999 - "When compared to mice on a standard diet, mice given food supplemented with 0.5% BBIC during and after dextran sulfate sodium treatment showed suppression of three of four scored histopathological inflammation criteria (P < 0.01), total histopathological score (P < 0.01), a 15% lower mortality rate (P < 0.01), and a delayed onset of mortality. " 08/01/2008 - "This study addresses the role of Raf in epithelial cell survival in response to dextran sulfate sodium (DSS)-induced injury and inflammation. " 01/01/2007 - "The aim of this study was to investigate the metabolic changes that may occur during acute and chronic colonic inflammation induced by dextran sulfate sodium (DSS) in mice. " 12/01/2001 - "The aim of this study is to investigate the correlation of rectum-associated lymph nodules (RALN) and the development of a dextran sulfate sodium-induced experimentally acute colonic inflammation in rats. "
3.	Ulcerative Colitis 05/26/2015 - "In our study, we used current biomedical approaches to investigate the therapeutic efficacy of BXD and possible protective mechanism involved in inhibiting dextran sulfate sodium (DSS)-induced chronic ulcerative colitis model. " 01/01/2012 - "The aim of this study was to investigate the protective effects of CA against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). " 11/01/2014 - "Ulcerative colitis was induced using 5% (w/v) dextran sulfate sodium in normal drinking water for 1, 7-day cycle in short-term study and 2.5% (w/v) dextran sulfate sodium in normal drinking water for 4 cycles with 2 weeks remission period between each cycle in long-term study. " 11/04/2015 - "Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice." 01/01/2013 - "The noncommensal bacterium Methylococcus capsulatus (Bath) ameliorates dextran sulfate (Sodium Salt)-Induced Ulcerative Colitis by influencing mechanisms essential for maintenance of the colonic barrier function."
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/01/2014 - "This study aimed to elucidate the functional mechanism and therapeutic efficacy of bacterial β-(1,3)-glucan in dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD).Mice were orally pretreated with bacterial β-(1,3)-glucan at daily doses of 2.5 or 5mg/kg for 2 weeks. " 07/01/2008 - "Using a mouse model of episodic inflammatory bowel disease by repeated administration of dextran sulfate sodium in the drinking water, we show that Aag-mediated DNA repair prevents colonic epithelial damage and reduces the severity of dextran sulfate sodium-induced colon tumorigenesis. " 02/21/2015 - "To investigate the effects of mesenchymal stem cells (MSCs) on dextran sulfate sodium-induced inflammatory bowel disease (IBD). " 07/01/2014 - "In mice given oral dextran sulfate, PrP(C) has a potential protective role against inflammatory bowel disease. " 12/01/2012 - "To develop an experimental rat model of inflammatory bowel disease (IBD) by administration of dextran sulfate sodium (DSS), and to observe changes in the tight junction protein expression and permeability of colon mucosa. "
5.	Infection 08/01/1994 - "Concentrations of CRDS that were protective against infection with T cell- and macrophage-tropic HIV-1 isolates had less suppressive effects on T cell function in comparison with the related compound, dextran sulfate." 09/01/1995 - "Under the conditions used, the polysulfate dextran sulfate conferred only partial protection against infection and virus-induced mortality. " 06/01/1995 - "The block to sog9 cell infection by HSV-1 could be eliminated by adding soluble dextran sulfate to the inoculum, which may act by stabilizing the virus at the sog9 cell surface. " 03/01/2004 - "In vitro studies of the effectiveness of these compounds at inhibiting infection of U373-MAGI-CCR5 cells by HIV-1 Ba-L indicated that the sulfated glycodendrimers were better inhibitors than the nonsulfated glycodendrimers, but not as effective as dextran sulfate." 12/01/2013 - "DS10 (dextran sulfate MW 10 kDa) was the most effective agent in these in vitro experiments and was therefore tested for its inhibitory effects in animal experiments; infection inhibition by DS10 was confirmed under these in vivo conditions. "

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Related Therapies and Procedures

1.	Oral Administration
2.	Blood Component Removal (Apheresis)
3.	Plasmapheresis
4.	Microspheres (Microsphere)
5.	Transplantation (Transplant Recipients)