Lewis X Antigen

A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, Lewis X antigen is a stage-specific embryonic antigen.

Also Known As:

3 alpha-Fucosyl-N-Acetyl Lactosamine; CD15 Antigen; Galbeta(1-4)Fucalpha(1-3)GlcNAc; Hapten X; Lewis X Hapten; SSEA 1; 3 alpha Fucosyl N Acetyl Lactosamine; Antigen, Lewis X; Embryonic Antigen-1, Stage-Specific; Leu M1 Antigens; SSEA 1 Determinant; Stage Specific Embryonic Antigen 1; X Antigen, Lewis; X Hapten, Lewis; Antigens, CD15; CD15 Antigens; Le(X) Antigen; Leu-M1 Antigens; Lewis X Related Antigens; SSEA-1; SSEA-1 Determinant; Stage-Specific Embryonic Antigen-1

Networked: 164 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Tumor Biomarkers: 15272
    - Carbohydrate Tumor-Associated Antigens: 355
      - Lewis X Antigen: 164
        Sialyl Lewis X Antigen: 674
        lewis(a)-lewis(x): 21
        Leu-M1 antigen: 12
        sialosyl dimeric Le(x) antigen: 8
        galactosyl-(1,4)-fucopyranosyl-(1,3)-N-acetylglucosamine: 4
        (3-deoxyxylohexopyranosyl)-1-4-(1-fucopyranosyl-1-3)-(2-deoxy-2-acetamidoglucopyranosyl)-1-3-galactopyranosyl-1-4-glucopyranosyl-(1-1)-2-octadecanamido-4-octadecene-1,3-diol
        (4-deoxyxylohexopyranosyl)-1-4-(1-fucopyranosyl-1-3)-(2-deoxy-2-acetamidoglucopyranosyl)-1-3-galactopyranosyl-1-4-glucopyranosyl-(1-1)-2-octadecanamido-4-octadecene-1,3-diol
        3-sulfated Lewis x
        Gal-1-3-Lewis(x) hexaglycosylceramide
        KDN-Lewis X ganglioside
        Lewis x oligosaccharide
  - Differentiation Antigens: 2082
    - Myelomonocytic Differentiation Antigens: 1
      - Lewis X Antigen: 164
        Sialyl Lewis X Antigen: 674
        lewis(a)-lewis(x): 21
        Leu-M1 antigen: 12
        sialosyl dimeric Le(x) antigen: 8
        galactosyl-(1,4)-fucopyranosyl-(1,3)-N-acetylglucosamine: 4
        (3-deoxyxylohexopyranosyl)-1-4-(1-fucopyranosyl-1-3)-(2-deoxy-2-acetamidoglucopyranosyl)-1-3-galactopyranosyl-1-4-glucopyranosyl-(1-1)-2-octadecanamido-4-octadecene-1,3-diol
        (4-deoxyxylohexopyranosyl)-1-4-(1-fucopyranosyl-1-3)-(2-deoxy-2-acetamidoglucopyranosyl)-1-3-galactopyranosyl-1-4-glucopyranosyl-(1-1)-2-octadecanamido-4-octadecene-1,3-diol
        3-sulfated Lewis x
        Gal-1-3-Lewis(x) hexaglycosylceramide
        KDN-Lewis X ganglioside
        Lewis x oligosaccharide
- Antigens: 143924

Experts

1.	Pucéat, Michel: 3 articles (03/2015 - 01/2014)
2.	Drickamer, Kurt: 3 articles (03/2011 - 01/2007)
3.	Mordoh, José: 3 articles (03/2011 - 01/2007)
4.	Taylor, Maureen E: 3 articles (03/2011 - 01/2007)
5.	Heimburg-Molinaro, Jamie: 2 articles (12/2021 - 11/2011)
6.	Do, Anh Duy: 2 articles (06/2021 - 01/2021)
7.	Hsu, Yuan-Man: 2 articles (06/2021 - 01/2021)
8.	Su, Chiu-Hsian: 2 articles (06/2021 - 01/2021)
9.	Bel, Alain: 2 articles (08/2015 - 01/2014)
10.	Bellamy, Valérie: 2 articles (08/2015 - 01/2014)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 06/01/2001 - "Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma." 01/01/2023 - "A potential role of SSEA-1 in metastasis was confirmed by pairwise staining of primary- and corresponding lymph node tumors. " 06/15/1993 - "Expression of the CD15 antigen, which is one of the adhesion molecules, was studied immunohistochemically to investigate the mechanism of intrahepatic metastasis in 56 hepatocellular carcinomas (HCC). " 10/01/2014 - "To confirm the effects of Lewis y antigen on HE4-mediated invasion and metastasis of ovarian cancer cells, the CaoV-3 cells with high Lewis y antigen on the HE4 surface and ES-2 cells, with high Lewis x antigen but low Lewis y antigen, were investigated. " 10/01/1992 - "Of 36 invasive bladder carcinoma patients with no metastasis at operation, 8 (57%) of 14 with high expression of SSEA-1 antigen died of cancer or had metastasis, whereas 4 (18%) of 22 with low or no expression had progression of the disease. "
2.	Neoplasms (Cancer) 03/30/2017 - "Our results document, for the first time, the expression of SSEA-1 in several canine cancer cell lines." 12/01/2016 - "SSEA-1 immunoreactivity was identified in malignant thyroid follicular epithelial cancers but not in the benign thyroid tissues. " 12/01/2016 - "To evaluate the potential diagnostic and prognostic utility of SSEA-1 in thyroid tumors, we analyzed the expression of SSEA-1 in normal and neoplastic thyroid tissues by immunohistochemistry (IHC) using a tissue microarray with 158 different tissue cores. " 12/01/2016 - "SSEA-1 may be expressed in normal stem cells and cancer stem-like cells. " 06/01/2013 - "The Lewis X (Le(X)) antigen is a prognostic marker in certain solid tumors and has been proposed as a therapeutic target. "
3.	Carcinoma (Carcinomatosis) 09/11/2008 - "In the invasive cervical carcinomas, we observed a loss of expression of the Le(x) antigen (p < 0.01). " 06/01/2000 - "The Lewis-X antigen, for the first time used on laryngeal carcinoma, seems to be a strong prognostic marker deserving further investigations." 06/01/1987 - "In mucosa adjacent to carcinoma of sporadic cases, SSEA-1 was expressed not only in the lower crypts but also in the upper crypts. " 06/01/1987 - "In mucosa remote from carcinoma of sporadic cases, SSEA-1 was expressed only faintly in the lower crypts. " 05/01/1986 - "Expression of Leu-M1 antigens in bladder epithelium seems to be specific for malignant change and highly frequent in the carcinoma patients. "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 08/01/1995 - "A study was made to determine the sensitivity and specificity of immunostaining of the Lewis X antigen in exfoliated urothelial cells from voided urine, for the detection and surveillance of bladder tumors. " 12/18/2021 - "Using a variety of approaches including flow cytometry, immunofluorescence, glycomics and gene expression analysis, we observed that the low-grade bladder cancer cell lines RT4, 5637 and SW780 express high levels of the fucosylated Lewis-X antigen (Lex, CD15) (Galβ1-4(Fucα1-3)GlcNAcβ1-R), while normal bladder epithelial A/T/N cells lack Lex expression. " 02/01/1998 - "We examined the use of immunostaining of the Lewis X antigen in exfoliated cells from voided urine samples, cytopathology and bladder ultrasound for noninvasive detection of bladder tumors as a potential substitute for cystoscopy. " 08/01/1995 - "Detection of bladder tumors by immunostaining of the Lewis X antigen in cells from voided urine." 02/01/1990 - "Enhanced bladder cancer detection with the Lewis X antigen as a marker of neoplastic transformation."
5.	Colorectal Neoplasms (Colorectal Cancer) 06/01/2001 - "Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma." 04/01/1986 - "Heterogeneous expression of two oncodevelopmental antigens, CEA and SSEA-1, in colorectal cancer." 04/01/1986 - "To assess cellular heterogeneity, the expression has been examined of two oncodevelopmental antigens, carcinoembryonic antigen (CEA) and stage-specific embryonic antigen 1 (SSEA-1), by double immunofluorescence microscopy on 11 human colorectal carcinomas. " 12/01/1990 - "Sialyl-dimeric Lewis-X antigen expressed on mucin-like glycoproteins in colorectal cancer metastases."

Related Drugs and Biologics

1.	Antigens
2.	Lewis X Antigen
3.	Carbohydrates
4.	Sialyl Lewis X Antigen
5.	Epitopes
6.	Antibodies
7.	stage-specific embryonic antigen-3 (GL-X)
8.	Immunoglobulin M (IgM)
9.	Immunoglobulin G (IgG)
10.	Brachyury protein (Brachyury)

Related Therapies and Procedures

1.	Operative Surgical Procedures
2.	Lasers (Laser)
3.	Injections
4.	Gastrectomy
5.	Drug Therapy (Chemotherapy)