Insertional Mutagenesis
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Also Known As:
Mutagenesis, Insertional; Activation, Insertional; Activations, Insertional; Cassette Mutagenesis; Gene Insertions; Insertion Mutations; Insertion, Gene; Insertion, Sequence; Insertional Activations; Insertional Mutagenesis, Viral; Insertions, Gene; Insertions, Sequence; Linker Insertion Mutagenesis; Mutagenesis, Linker-Insertion; Mutagenesis, Viral Insertional; Mutation, Insertion; Mutations, Insertion; Sequence Insertions; Gene Insertion; Insertion Mutation; Insertional Activation; Linker-Insertion Mutagenesis; Mutagenesis, Cassette; Sequence Insertion; Viral Insertional Mutagenesis
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