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Amyloid beta-Peptides

Subscribe to New Research on Amyloid beta-Peptides

Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.

Also Known As:

Alzheimer's ABP; Alzheimer's Amyloid Fibril Protein; Amyloid AD-AP; Amyloid Fibril Protein, Alzheimer's; Amyloid beta-Proteins; ABP, Alzheimer's; AD-AP, Amyloid; Alzheimer ABP; Alzheimer beta Protein; Alzheimers ABP; Amyloid AD AP; Amyloid beta Peptide; Amyloid beta Peptides; Amyloid beta Protein; Amyloid beta Proteins; Protein A4, Amyloid; Protein, beta-Amyloid; beta Amyloid Protein; beta-Peptide, Amyloid; beta-Peptides, Amyloid; beta-Protein, Alzheimer; beta-Protein, Amyloid; beta-Proteins, Amyloid; Alzheimer beta-Protein; Amyloid Protein A4; Amyloid beta-Peptide; Amyloid beta-Protein; beta-Amyloid Protein

Networked: 3327 relevant articles (49 outcomes, 176 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Amyloid: 22775
    - Amyloidogenic Proteins: 305
      - Amyloid beta-Protein Precursor: 416
        Amyloid beta-Peptides: 3327
        amyloid beta-protein (1-42): 187
        amyloid beta-protein (1-40): 52
        AN-1792: 49
        amyloid beta-protein (25-35): 46
        amyloid beta-protein (40-42): 5
        amyloid beta-protein (16-20): 2
        amyloid beta-protein (1-15): 1
        amyloid beta-protein (12-36): 1
        amyloid beta-protein (16-35): 1
        amyloid beta-protein (17-42): 1
        amyloid beta-protein (2-42): 1
        amyloid beta-peptide (5-40)
        amyloid beta-peptide (5-42)
        amyloid beta-peptide (8-14)
        amyloid beta-peptide (9-42)
        amyloid beta-protein (1-11)
        amyloid beta-protein (1-12)
        amyloid beta-protein (1-16)
        amyloid beta-protein (1-28)
        amyloid beta-protein (1-34)
        amyloid beta-protein (1-38)
        amyloid beta-protein (1-41)
        amyloid beta-protein (1-43)
        amyloid beta-protein (1-5)
        amyloid beta-protein (1-6)
        amyloid beta-protein (10-21)
        amyloid beta-protein (10-35)
        amyloid beta-protein (10-43)
        amyloid beta-protein (11-25)
        amyloid beta-protein (11-28)
        amyloid beta-protein (12-28)
        amyloid beta-protein (13-17)
        amyloid beta-protein (13-28)
        amyloid beta-protein (16-22)
        amyloid beta-protein (19-28)
        amyloid beta-protein (2-9)
        amyloid beta-protein (20-29)
        amyloid beta-protein (21-30)
        amyloid beta-protein (21-35)
        amyloid beta-protein (25-36)
        amyloid beta-protein (25-38)
        amyloid beta-protein (25-40)
        amyloid beta-protein (29-40)
        amyloid beta-protein (31-35)
        amyloid beta-protein (34-39)
        amyloid beta-protein (34-42)
        amyloid beta-protein (35-25)
        amyloid beta-protein (35-43)
        amyloid beta-protein (40-1)
        amyloid beta-protein (6-25)
        amyloid beta-protein (9-25)
        amyloid-beta(40-1)-Gly8-1-40 peptide
        beta-amyloid (15-28)
        beta-amyloid peptide (29-42)
        beta-amyloid peptide 1-42 (E22delta) click peptide
        beta-amyloid(phenyl(SO3H)24)25-35 peptide
        Glu(18,19)- amyloid beta (1-30)-amide
        Glu(18,19)- Lys-Lys-Lys-Lys-Lys-Lys-amyloid beta (1-30)-amide
        human amyloid beta-protein p3
        iAbeta5 peptide
        Lys-Lys-Lys-Lys-Lys-Lys-amyloid beta (1-30)-amide
        pyroglutamyl(3)- amyloid beta-protein (3-42)
  - Membrane Proteins: 5300
    - Amyloid beta-Protein Precursor: 416
      - Amyloid beta-Peptides: 3327
        amyloid beta-protein (1-42): 187
        amyloid beta-protein (1-40): 52
        AN-1792: 49
        amyloid beta-protein (25-35): 46
        amyloid beta-protein (40-42): 5
        amyloid beta-protein (16-20): 2
        amyloid beta-protein (1-15): 1
        amyloid beta-protein (12-36): 1
        amyloid beta-protein (16-35): 1
        amyloid beta-protein (17-42): 1
        amyloid beta-protein (2-42): 1
        amyloid beta-peptide (5-40)
        amyloid beta-peptide (5-42)
        amyloid beta-peptide (8-14)
        amyloid beta-peptide (9-42)
        amyloid beta-protein (1-11)
        amyloid beta-protein (1-12)
        amyloid beta-protein (1-16)
        amyloid beta-protein (1-28)
        amyloid beta-protein (1-34)
        amyloid beta-protein (1-38)
        amyloid beta-protein (1-41)
        amyloid beta-protein (1-43)
        amyloid beta-protein (1-5)
        amyloid beta-protein (1-6)
        amyloid beta-protein (10-21)
        amyloid beta-protein (10-35)
        amyloid beta-protein (10-43)
        amyloid beta-protein (11-25)
        amyloid beta-protein (11-28)
        amyloid beta-protein (12-28)
        amyloid beta-protein (13-17)
        amyloid beta-protein (13-28)
        amyloid beta-protein (16-22)
        amyloid beta-protein (19-28)
        amyloid beta-protein (2-9)
        amyloid beta-protein (20-29)
        amyloid beta-protein (21-30)
        amyloid beta-protein (21-35)
        amyloid beta-protein (25-36)
        amyloid beta-protein (25-38)
        amyloid beta-protein (25-40)
        amyloid beta-protein (29-40)
        amyloid beta-protein (31-35)
        amyloid beta-protein (34-39)
        amyloid beta-protein (34-42)
        amyloid beta-protein (35-25)
        amyloid beta-protein (35-43)
        amyloid beta-protein (40-1)
        amyloid beta-protein (6-25)
        amyloid beta-protein (9-25)
        amyloid-beta(40-1)-Gly8-1-40 peptide
        beta-amyloid (15-28)
        beta-amyloid peptide (29-42)
        beta-amyloid peptide 1-42 (E22delta) click peptide
        beta-amyloid(phenyl(SO3H)24)25-35 peptide
        Glu(18,19)- amyloid beta (1-30)-amide
        Glu(18,19)- Lys-Lys-Lys-Lys-Lys-Lys-amyloid beta (1-30)-amide
        human amyloid beta-protein p3
        iAbeta5 peptide
        Lys-Lys-Lys-Lys-Lys-Lys-amyloid beta (1-30)-amide
        pyroglutamyl(3)- amyloid beta-protein (3-42)
- Peptides: 22950
  - Amyloid beta-Peptides: 3327

Experts

1.	Selkoe, Dennis J: 48 articles (01/2012 - 04/2002)
2.	Butterfield, D Allan: 31 articles (01/2010 - 06/2002)
3.	Haass, Christian: 30 articles (08/2010 - 07/2002)
4.	Teplow, David B: 30 articles (07/2010 - 01/2002)
5.	Masters, Colin L: 29 articles (01/2010 - 06/2002)
6.	Barnham, Kevin J: 25 articles (01/2010 - 01/2003)
7.	Lahiri, Debomoy K: 24 articles (01/2015 - 01/2002)
8.	Saido, Takaomi C: 24 articles (08/2010 - 05/2002)
9.	Walsh, Dominic M: 20 articles (05/2010 - 04/2002)
10.	Wolfe, Michael S: 19 articles (01/2014 - 04/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 05/01/2010 - "Among these, strategies targeting the production and clearance of the amyloid-beta peptide - a cardinal feature of Alzheimer's disease that is thought to be important in disease pathogenesis - are the most advanced. " 01/01/2005 - "Over the past few years, amyloid beta protein (Abeta) vaccination has become one of the most effective treatments for Alzheimer's disease. " 06/01/2007 - "Accumulating evidence suggests that bone-marrow (BM)-derived mononuclear phagocytes have an important role in the clearance of soluble and aggregated amyloid-beta peptides (Abeta) in Alzheimer's disease (AD) brains. " 05/01/2005 - "As Alzheimer's disease pathogenesis is associated with the formation of insoluble aggregates of amyloid beta-peptide, approaches allowing the direct, noninvasive visualization of plaque growth in vivo would be beneficial for biomedical research. " 08/05/1991 - "In Alzheimer's disease beta-amyloid protein load in neocortex and hippocampus was significantly greater than in non-demented age-matched controls. "
2.	Amyloid Plaque 05/01/2008 - "Recent studies using ABCA1 knockout mice have demonstrated that ABCA1 affects amyloid-beta peptide (A beta) levels in the brain and the production of senile plaque. " 05/01/2003 - "Aggregation of Amyloid beta-protein(A beta) in senile plaques is related to the pathogenesis of AD, so it is very important for the studies on the prevention of A beta deposition and on trying to disaggregate the senile plaques, aimed at treatment and prevention of the AD. " 03/07/2003 - "In this study we report that amyloid beta-peptides (Abeta) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain." 08/01/2000 - "Recent studies have demonstrated the generation of beta-amyloid protein (Abeta) 1-42, a key peptide for amyloid deposits, in the ER. " 12/01/1998 - "Recent studies suggest that mutations in APP, PS 1 or PS 2 result in increased production of amyloid beta protein (A beta), a major constituent of senile plaques. "
3.	Inflammation 10/01/2000 - "There are two pathological defects in AD: chronic inflammation and impaired clearance of amyloid beta-peptide (Abeta). " 10/01/2011 - "In the present work, we have characterised the induction of inflammation in the rat retina following intravitreal administration of amyloid-beta protein (Aβ). " 04/15/2010 - "Amyloid-beta peptide is the main inducer of inflammation in AD. " 12/01/2008 - "However, the pathological pathways from amyloid-beta peptide oligomerization to the major pathological hallmarks of AD, such as neurofibrillary tangles, inflammation and loss of cholinergic neurons, are largely unknown. " 07/01/2005 - "Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures."
4.	Dementia (Dementias) 04/01/2013 - "Impaired clearance of neurotoxic amyloid beta peptides (Abeta) leads to dementia in AD. " 07/16/2014 - "Plaques composed of aggregated amyloid-beta protein (Aβ) accumulate between the neural cells in the brain and are associated with dementia and cellular death. " 11/01/2012 - "A low beta amyloid protein rate (479 mg/L) found in cerebrospinal fluid suggests a possible link between SHANK3 deletion syndrome-associated regression and dementia of Alzheimers's type. " 09/23/2011 - "The experimental dementia models were established by injecting beta-amyloid protein 1-40 (Aβ1-40) stereotactically into the left lateral ventricle, and treated by injecting NRG1β into right lateral ventricle. " 09/01/2010 - "This theory posits that the deposition of amyloid-beta protein (Abeta) in the brain is the key pathologic event in AD, which induces a series of neuropathological changes that manifest as cognitive decline and eventual dementia. "
5.	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 02/21/2007 - "Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging." 01/01/2015 - "Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. " 08/01/2009 - "Cerebral amyloid angiopathy is caused by deposition of the amyloid beta protein in the cerebral vasculature. " 06/01/2008 - "Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid beta-protein (A beta) within cerebral vessels. " 04/01/2006 - "Pathological measures of amyloid beta protein (Abeta), as plaque Abeta40 and Abeta42(3) load and degree of cerebral amyloid angiopathy were made by image analysis or semiquantitative rating, respectively. "

Related Drugs and Biologics

1.	Antibodies
2.	Amyloid (Amyloid Fibrils)
3.	Copper
4.	Insulysin (Insulin-Degrading Enzyme)
5.	Insulin (Novolin)
6.	Neurotransmitter Agents (Neurotransmitter)
7.	resveratrol
8.	Apolipoproteins E (ApoE)
9.	Apolipoproteins
10.	tau Proteins (tau Protein)

Related Therapies and Procedures

1.	Immunotherapy
2.	Electroacupuncture
3.	Serial Extraction
4.	Ovariectomy (Oophorectomy)
5.	Electrodes (Electrode)