Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

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Networked: 3927 relevant articles (111 outcomes, 542 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Tabata, Yasuhiko: 41 articles (08/2014 - 07/2002)
2.	Presta, Marco: 14 articles (08/2015 - 06/2003)
3.	Komeda, Masashi: 14 articles (12/2008 - 07/2002)
4.	Yang, Li: 11 articles (10/2015 - 06/2003)
5.	Kardami, Elissavet: 11 articles (09/2013 - 02/2002)
6.	Azar, Dimitri T: 10 articles (04/2015 - 01/2003)
7.	Ribatti, Domenico: 10 articles (12/2013 - 12/2004)
8.	Yonemitsu, Yoshikazu: 10 articles (03/2013 - 01/2002)
9.	Hasegawa, Mamoru: 10 articles (03/2013 - 01/2002)
10.	Ribatti, D: 10 articles (01/2010 - 11/2000)

Related Diseases

1.	Wounds and Injuries (Trauma) 03/01/1992 - "The addition of basic fibroblast growth factor at the 100 micrograms/cm2 dosage level markedly improved the rate of wound closure whereas inert vehicles applied alone were ineffective. " 01/01/2010 - "At the same time, this macrophage population improved wound healing rate in normal mice and FGF-2 expression was also increased in these wounds. " 03/01/2002 - "To evaluate the safety and efficacy of topical application of recombinant bovine basic fibroblast growth factor (rbFGF) on the healing of chronic cutaneous wounds. " 02/14/2000 - "When PEO/PLLA multiblock copolymers were applied as a wound healing material loaded with basic fibroblast growth factor (bFGF), the feasibility study showed improved wound healing when compared to controls of no treatment and the same wound covering without bFGF, indicating that a certain degree of the bioactivity of bFGF is preserved." 08/01/1992 - "Using standardized freeze wounds in cat corneas, we tested the efficacy of basic Fibroblast Growth Factor (bFGF) solubilized in phosphate buffered saline (PBS) to promote endothelial healing when injected intraocularly at doses ranging from 0.01 microgram to 10 micrograms. "
2.	Neoplasms (Cancer) 04/01/2004 - "This study demonstrates that the truncated form of 24-kd basic fibroblast growth factor is effective in suppressing tumor development in vivo through inhibition of angiogenesis as well as inhibition of tumor cell migration without compromising other homeostatic events." 05/01/2015 - "An OV engineered to express FGF2 was safe in tumor-bearing mice, showed improved therapeutic efficacy compared to parental virus and merits consideration for clinical testing. " 12/01/2010 - "These data indicate that regulatory interactions between FGF-AS and FGF-2 are involved in control of cell adhesion, cell-cycle progression, and invasion, providing a possible explanation for the protective effects of FGF-AS expression observed in FGF-2-dependent cancers." 05/01/2014 - "The Cancer Genome Atlas (TCGA) data was used to study correlations between gene expression and amplification or methylation of FGFR1, FGFR2, and FGF2 in basal-like TNBC. " 06/01/2013 - "Recent studies have reported oxidative damage due to bisphosphonate (BP) in various cancer tissues and neurons, although basic fibroblast growth factor (bFGF) induced antioxidant effects in the cells. "
3.	Ischemia 12/06/2006 - "Aged rats given FGF-2 pre-ischemia showed better symmetry of movement and forepaw outstretching, and reduced infarct volumes, compared to rats treated with vehicle, but no significant improvement was found in aged rats given FGF-2 after focal ischemia. " 11/01/2002 - "In contrast to the TMLR- and control group, CO(2)-laser revascularization combined with the application of intramyocardial growth factor, FGF-2, significantly ameliorates perfusion at rest and stress in this model of chronic regional ischemia, whereas sole FGF-2 application showed an improvement at rest only. " 09/01/2005 - "Therapeutic efficacy of basic fibroblast growth factor on experimental focal ischemia studied by magnetic resonance imaging." 07/01/2003 - "We previously reported adenovirus-mediated ex vivo gene transfer of basic fibroblast growth factor (bFGF) as a new treatment for leg ischemia. " 01/01/2015 - "To assess the cardioprotective efficacy of endogenous FGF2, mice lacking a functional Fgf2 gene (Fgf2(-/-)) and wild-type controls were subjected to closed-chest regional cardiac IR injury (90 min ischemia, 7 days reperfusion). "
4.	Ulcer 09/01/2009 - "Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer." 04/01/1997 - "This study was conducted to examine the hypothesis that basic fibroblast growth factor (bFGF) may have an anti-ulcer action through an acid-independent mechanism. " 02/01/2015 - "PTX3 was elevated in SSc patients who had digital ulcers or PAH, while FGF-2 was reduced in SSc patients with PAH. " 02/01/2009 - "(4) TREATMENT: The cervical ulcer in Behcet's disease can be treated by the topical application of recombinant bovine basic fibroblast growth factor (rb-bFGF). " 01/01/2007 - "We describe here nine cases of different types of therapy-resistant ulcers that were successfully treated with the employment of spraying with basic fibroblast growth factor once daily. "
5.	Myocardial Infarction 09/04/1992 - "In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced infarct size. " 09/01/2008 - "The aim of this study was to explore the effect of bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2)- paracrine factors implicated in both cardiac embryogenesis and cardiac repair following myocardial infarction (MI)-on murine bone marrow stem cell (mBMSC) differentiation in an ex vivo cardiac microenvironment. " 04/01/2003 - "The present study in rats investigated whether basic fibroblast growth factor (bFGF) plays an important role in cardioprotection against myocardial cell death and arrhythmias in acute myocardial infarction (AMI). " 11/01/2000 - "[Immunohistochemical study of basic fibroblast growth factor of early myocardial infarction]." 03/01/1999 - "A study to determine if basic fibroblast growth factor (bFGF) reduces myocardial infarct size in acute coronary arterial occlusion."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Messenger RNA (mRNA)
5.	Platelet-Derived Growth Factor
6.	DNA (Deoxyribonucleic Acid)
7.	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
8.	Insulin (Novolin)
9.	Cytokines
10.	Heparin (Liquaemin)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Injections
3.	Skin Transplantation (Skin Grafting)
4.	Radiotherapy
5.	Drug Therapy (Chemotherapy)