Macrophage-Activating Factors

Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.

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Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Doğan, Başak: 1 article (01/2022)
2.	Görgülü, Nimet Gül: 1 article (01/2022)
3.	Descargues, Pascal: 1 article (01/2009)
4.	Grivennikov, Sergei: 1 article (01/2009)
5.	Karin, Michael: 1 article (01/2009)
6.	Kim, Sunhwa: 1 article (01/2009)
7.	Kim, Youngjun: 1 article (01/2009)
8.	Lin, Wan-Wan: 1 article (01/2009)
9.	Luo, Jun-Li: 1 article (01/2009)
10.	Takahashi, Hiroyuki: 1 article (01/2009)

Related Diseases

1.	Periodontitis 01/01/2022 - "This study aimed to evaluate the levels of total matrix metalloproteinase-8 (MMP-8), macrophage-activating factors (MAF), macrophage inflammatory protein (MIP)-1α, macrophage colony-stimulating factor (M-CSF), interleukin (IL)-34 in saliva, and serum of periodontally healthy, periodontitis Stage III Grade B (P-III-B) and Grade C (P-III-C) participants and to compare the changes after non-surgical periodontal treatment (NSPT). "
2.	Neoplasms (Cancer) 02/01/1989 - "Tumor-specific T cells which form clusters with dendritic cells and tumor cells and deliver macrophage-activating factors." 03/01/1988 - "It is possible that CTL, triggered by Ag recognition to exocytose storage granules and to synthesize and constitutively exocytose macrophage-activating factors, in turn promote tumor destruction by macrophages.(ABSTRACT TRUNCATED AT 400 WORDS)" 03/01/1986 - "Macrophages, activated by T cell-derived macrophage activating factors (MAF), are able to kill obligate intracellular parasites and tumor cells(1-10) including Leishmania, certain trypanosomes, Toxoplasma, the obligate intracellular bacterium Rickettsia, and perhaps bacteria such as mycobacteria and Legionella. " 01/01/2009 - "To understand how cancer cells affect the inflammatory microenvironment, we conducted a biochemical screen for macrophage-activating factors secreted by metastatic carcinomas. "
3.	Infections 06/15/1996 - "NK cells in turn produce and secrete monocyte/macrophage activating factors such as interferongamma (IFN-gamma), which are important in the early control of these infections. " 01/01/1992 - "tularensis infection in mice induces the production of macrophage activating factors (MAFs) by spleen cells. " 09/01/2000 - "These results suggest that DN TCRalphabeta+ T cells were activated and may have an antiviral effect through producing IFN-gamma and some macrophage-activating factors during an early phase of MCMV infection."
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/1987 - "Human T cell hybridoma, H3-E9-6, that produces macrophage activating factors for cytotoxicity (MAF-C) was prepared by somatic fusion of phytohemagglutinin-activated peripheral blood lymphocytes with emetine/actinomycin D-treated cloned human acute lymphocytic leukemia cells (CEM 11). "
5.	Tularemia 01/01/1992 - "Macrophage activating factors produced in the course of murine tularemia: effect on multiplication of microbes."

Related Drugs and Biologics

1.	Matrix Metalloproteinase 8 (Neutrophil Collagenase)
2.	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)
3.	Macrophage Colony-Stimulating Factor
4.	Interleukins
5.	Interleukin-8 (Interleukin 8)
6.	Cytokines
7.	Interleukin-6 (Interleukin 6)
8.	Superoxides (Superoxide)
9.	Phytohemagglutinins
10.	Nitric Oxide (Nitrogen Monoxide)