Transforming Growth Factor alpha (TGF-alpha)

Factor isolated in a variety of tissues including epithelium, and maternal decidua. It is closely related to EPIDERMAL GROWTH FACTOR and binds to the EGF receptor. TGF-alpha acts synergistically with TGF-beta in inducing phenotypic transformation, but its physiological role is unknown.

Also Known As:

Networked: 1912 relevant articles (37 outcomes, 265 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Korfhagen, Thomas R: 11 articles (07/2010 - 04/2002)
2.	Hardie, William D: 11 articles (07/2010 - 04/2002)
3.	Fidler, Isaiah J: 10 articles (07/2008 - 07/2002)
4.	Le Cras, Timothy D: 8 articles (02/2010 - 11/2003)
5.	Calvisi, Diego F: 8 articles (08/2008 - 05/2003)
6.	Thorgeirsson, Snorri S: 8 articles (07/2005 - 01/2003)
7.	Whitsett, Jeffrey A: 7 articles (07/2010 - 11/2003)
8.	Grande, Joseph P: 7 articles (08/2009 - 09/2002)
9.	Cleary, Margot P: 7 articles (08/2009 - 09/2002)
10.	Rubenstein, Marvin: 7 articles (01/2009 - 01/2003)

Related Diseases

1.	Neoplasms (Cancer) 11/30/2000 - "Finally, tumors from mice treated with TGFalpha, AR and CR AS MBOs showed a significant reduction of microvessel count, as compared with tumors from untreated mice or from mice treated with a single AS MBO. " 06/01/2002 - "Local tumor control as well as disease-free and overall survival were independent of protein expression levels, whereas combined TGFalpha and EGFR immunoreactivities were closely related to IMD (P = 0.003). " 03/01/1997 - "AE1/AE3, bcl-2, TGF-alpha, and p53 were not helpful in separating the tumors." 09/01/2005 - "This study investigated and compared the X-linked gene expression profiles of MMTV-c-myc transgenic mammary tumor (MT) or MMTV-c-myc/MT-tgf-alpha double transgenic mouse mammary tumor (DT) to lactating mammary gland. " 07/01/1997 - "This study indicated that altered TGF-alpha expression was detectable early in the development of renal cell tumors and may be an important feature of the transformed phenotype."
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/08/1999 - "In contrast to NHEK, IFN-gamma and TGFalpha are not very effective in inducing TGFalpha or COX-2 expression in several squamous carcinoma cell lines, indicating alterations in both IFN-gamma and TGFalpha response pathways." 08/01/1992 - "Here, we compare the efficacy of these three agents in the elevation of TGF-alpha secretion in the well studied A431 cell line with their previously undocumented efficacy in certain interesting, but little known, human oesophageal squamous cell carcinoma (SCC) lines." 05/01/2005 - "TGF-alpha, c-erbB-2 expression and neoangiogenesis in vulvar squamous cell carcinoma." 01/01/2001 - "The expression of TGF-alpha and EGFR was upregulated in OL, OSMF and oral squamous cell carcinomas relative to normal oral mucosa. " 11/01/2000 - "TGF-alpha antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo."
3.	Colorectal Neoplasms (Colorectal Cancer) 02/01/1998 - "Additional studies are warranted to determine if serum levels of transforming growth factor-alpha may be useful as a potential biomarker in the management of patients with colorectal cancer." 01/01/2009 - "TGF-alpha expression in the normal-appearing rectal mucosa shows promise as an early, potentially modifiable biomarker of risk for colorectal cancer." 06/01/2007 - "[Correlations of c-erb-B2, EGFR, and TGF-alpha expression to recurrence of Dukes'A and B colorectal carcinoma]." 03/01/2002 - "Tissue localization of TGFalpha and apoptosis are inversely related in colorectal tumors." 02/01/1998 - "Levels of preoperative transforming growth factor-alpha in patients with colorectal cancer appeared to be higher than levels measured in control subjects. "
4.	Wounds and Injuries (Trauma) 12/15/2006 - "Additional studies implicated TGF-alpha as the active EGFR ligand cleaved by TACE during wound repair. " 11/01/1992 - "Immunohistochemical study showed that keratinocytes migrating from wound edges expressed TGF-alpha very faintly, while TGF-alpha was present prominently in the upper several layers of the epidermis adjacent to the wound, which resembled normal epidermis and showed no changes during the wound healing process." 08/01/2010 - "Examination of the function of IL-24 in both in vitro wound repair and migration assays demonstrated that IL-24 inhibits TGFalpha-induced proliferation and migration of NHEKs. " 08/01/2010 - "IL-24 is expressed during wound repair and inhibits TGFalpha-induced migration and proliferation of keratinocytes." 09/01/2001 - "The data support the concept that transforming growth factor-alpha plays a significant early role in wound epithelialization in vivo but its deficit is compensated if accompanied by granulation tissue formation. "
5.	Hyperplasia 09/01/2008 - "Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis." 11/01/2005 - "More importantly, suppression of TGF-alpha/EGFR signaling, through prophylactic administration of potent and highly selective inhibitors of ligand-induced EGFR activation, completely prevented both high-P- and low-Ca-induced parathyroid hyperplasia as well as TGF-alpha self-upregulation. " 10/01/2005 - "LMP1(CAO) and LMP1(B95-8) induce transforming growth factor alpha expression and epidermal hyperplasia. " 05/01/2005 - "The increased expression of TGF-alpha and ErbB2 in RA SF and SM may give rise to an abnormal growth pattern, contributing to inflammatory synovial hyperplasia." 11/01/2003 - "A molecular biological analysis revealed high incidence of cellular proliferation activating factors such as TGF-alpha, COX-2 from the hyperplasia stage. "

Related Drugs and Biologics

1.	Transforming Growth Factor alpha (TGF-alpha)
2.	Epidermal Growth Factor (EGF)
3.	Epidermal Growth Factor Receptor (EGF Receptor)
4.	Antisense Oligonucleotides
5.	Messenger RNA (mRNA)
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	amphiregulin (schwannoma-derived growth factor)
8.	Transforming Growth Factors (Transforming Growth Factor)
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Insulin-Like Growth Factor II (Somatomedin A)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Oral Administration
3.	Chemoprevention
4.	Transplants (Transplant)
5.	Drug Therapy (Chemotherapy)