Maturation-Promoting Factor

Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.

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Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kucherlapati, Melanie Haas: 1 article (01/2022)
2.	Ekambaram, Rajasekaran: 1 article (11/2021)
3.	Heese, Klaus: 1 article (11/2021)
4.	Kim, Pok-Son: 1 article (11/2021)
5.	Kutzner, Arne: 1 article (11/2021)
6.	Pramanik, Subrata: 1 article (11/2021)
7.	Renganathan, Senthil: 1 article (11/2021)
8.	Liu, Guolong: 1 article (01/2019)
9.	Liu, Liren: 1 article (01/2019)
10.	Ma, Gang: 1 article (01/2019)

Related Diseases

1.	Adenoid Cystic Carcinoma (Cylindroma) 06/01/2007 - "To study the expression and clinical significance of M-phase promoting factor (MPF) in salivary adenoid cystic carcinoma (SACC). " 06/01/2007 - "[The expression of M-phase promoting factor in salivary adenoid cystic carcinoma]."
2.	Neoplasms (Cancer) 11/22/2021 - "Family with sequence similarity 72 A (FAM72A) is a pivotal mitosis-promoting factor that is highly expressed in various types of cancer. " 03/01/2002 - "[The activity of M-phase promoting factor in oral normal tissue and tumor]." 12/01/2004 - "We show that the recently discovered tumor suppressor pdcd4 represses the transcription of the mitosis-promoting factor cyclin-dependent kinase (CDK)1/cdc2 via upregulation of p21(Waf1/Cip1). " 03/01/2002 - "To investigate the content and activity of M-phase promoting factor (MPF) in pleomorphic adenoma, mucoepidermoid carcinoma, buccal carcinoma and normal tissue, in order to evaluate the role of MPF in the development of tumor and the relationship between MPF and malignant degree. " 01/01/2022 - ": TCGA: The cancer genome atlas; PANCAN: Pan cancer; CDK: Cyclin-dependent kinase; COAD: Colon adenocarcinoma; LUAD: Lung adenocarcinoma; Wnt: Wingless/integrated signaling; MAPK: Mitogen-activated protein kinase; APC: Adenomatous polyposis coli gene; CIN: Chromosomal instability; GS: Genome stabile; MMR: Mismatch repair; mRNA: Messenger RNA; RPKM: Reads per kilobase of transcription per million mapped reads; RSEM: RNA Seq by expectation maximization; FDR: False discovery rate; GTEx: Genotype-Tissue Expression portal; MPF: Maturation-promoting factor; SCF: Skp1-Cul1-F-box; HH: Hedgehog; EMT: Epithelial mesenchymal transition; RB: Retinoblastoma; EGFR: Epidermal growth factor receptor; rs or ρ: Spearman's correlation."
3.	Chromosome Breakage 10/01/1994 - "We previously showed that HeLa mitotic metaphase cells, when used as inducers of premature chromosome condensation (PCC), uncover two times more chromosome breaks in irradiated interphase cells than CHO mitotic metaphase cells, and have at the same time a 2.5-fold higher mitosis promoting factor (MPF) activity. " 12/01/1993 - "Mitosis-promoting factor activity of inducer mitotic cells may affect radiation yield of interphase chromosome breaks in the premature chromosome condensation assay."
4.	Infections 04/01/1994 - "Simian virus 40 prevents activation of M-phase-promoting factor during lytic infection." 11/01/1995 - "At early times, HCMV infection also induced cyclin B accumulation, which was associated with a significant increase in mitosis-promoting factor activity as the infection progresses. "
5.	Carcinogenesis 11/01/2007 - "The aim of this work was to investigate the relationship between survivin, its phosphorylated active form (p-survivin) and M-phase promoting factor (MPF), p34cdc2-cyclin B1 in oral carcinogenesis. " 11/01/2007 - "Survivin phosphorylation and M-phase promoting factor in oral carcinogenesis."

Related Drugs and Biologics

1.	Cyclin-Dependent Kinases (cdk Proteins)
2.	Proteins (Proteins, Gene)
3.	DNA (Deoxyribonucleic Acid)
4.	ErbB Receptors (EGF Receptor)
5.	Cyclin B1
6.	Proteasome Endopeptidase Complex (Proteasome)
7.	Intercellular Signaling Peptides and Proteins (Growth Factors)
8.	Mitogen-Activated Protein Kinases
9.	Cyclin B
10.	Cyclins