Colony-Stimulating Factor Receptors (Colony-Stimulating Factor Receptor)

Cell surface receptors for colony stimulating factors, local mediators, and hormones that regulate the survival, proliferation, and differentiation of hemopoietic cells.

Also Known As:

Colony-Stimulating Factor Receptor; Receptors, Colony-Stimulating Factor; CSF Receptors; Hematopoietic Growth Factor Receptor; Colony Stimulating Factor Receptor; Colony Stimulating Factor Receptors; Receptor, Colony-Stimulating Factor; Receptors, CSF; Receptors, Colony Stimulating Factor; Hematopoietic Growth Factors Receptors; Receptors, Hematopoietic Growth Factors

Networked: 28 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Colony-Stimulating Factor Receptors: 28
        Proto-Oncogene Proteins c-kit: 471
        Erythropoietin Receptors: 460
        Granulocyte Colony-Stimulating Factor Receptors: 168
        Macrophage Colony-Stimulating Factor Receptor: 168
        Granulocyte-Macrophage Colony-Stimulating Factor Receptors: 140
        Interleukin-3 Receptors: 97
        human CSF3R protein
        human CSF3R-SPTAN1 fusion protein
        mouse Csf3r protein
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Colony-Stimulating Factor Receptors: 28
        Proto-Oncogene Proteins c-kit: 471
        Erythropoietin Receptors: 460
        Granulocyte Colony-Stimulating Factor Receptors: 168
        Macrophage Colony-Stimulating Factor Receptor: 168
        Granulocyte-Macrophage Colony-Stimulating Factor Receptors: 140
        Interleukin-3 Receptors: 97
        human CSF3R protein
        human CSF3R-SPTAN1 fusion protein
        mouse Csf3r protein

Experts

1.	Moliterno, Alison R: 2 articles (01/2021 - 01/2020)
2.	Spivak, Jerry L: 2 articles (01/2021 - 01/2020)
3.	Albertson, Donna G: 1 article (09/2022)
4.	Dubeykovskaya, Zinaida A: 1 article (09/2022)
5.	Garcia, Paulina D Ramírez: 1 article (09/2022)
6.	Schmidt, Brian L: 1 article (09/2022)
7.	Tu, Nguyen Huu: 1 article (09/2022)
8.	Ferrer, Isidro: 1 article (06/2022)
9.	Kulkarni, Ashish A: 1 article (12/2021)
10.	Malik, Vaishali: 1 article (12/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2011 - "This is the first study performed to asses if the number of TAMs and expression of MCSF-R (macrophages colony stimulating factor receptor) and CD14 (LPS co-receptor) are associated with the grade of tumor malignancy and its ability to metastasize. " 01/01/2020 - "Paradoxically, MPL surface expression in hematopoietic stem cells is also reduced in the myeloproliferative neoplasms due to abnormal post-translational glycosylation and premature destruction of JAK2, suggesting that the myeloproliferative neoplasms are disorders of MPL processing since MPL is the only hematopoietic growth factor receptor in hematopoietic stem cells. " 12/01/2021 - "Macrophage colony-stimulating factor (MCSF) secreted by cancer cells binds to the colony-stimulating factor receptor present on macrophages and negatively influences macrophage functions. " 08/01/2020 - "Genomic analysis of the prognostic value of colony-stimulating factors (CSFs) and colony-stimulating factor receptors (CSFRs) across 24 solid cancer types." 01/01/2021 - "This abnormality is important because MPL is the only hematopoietic growth factor receptor expressed in hematopoietic stem cells; because MPL is a proto-oncogene; because impaired MPL processing results in chronic elevation of plasma thrombopoietin, and since these diseases involve normal hematopoietic stem cells, they have proven resistant to therapies used in other myeloid neoplasms. "
2.	Schizophrenia (Dementia Praecox) 06/01/2007 - "We report results of a case-control WGA study in schizophrenia, examining approximately 500 000 markers, which revealed a strong effect (P=3.7 x 10(-7)) of a novel locus (rs4129148) near the CSF2RA (colony stimulating factor, receptor 2 alpha) gene in the pseudoautosomal region. "
3.	Leukoencephalopathies 06/06/2022 - "However, ALSP linked to dominantly inherited mutations in CSF1R (colony stimulating factor receptor 1) cause CSF-1R-related leukoencephalopathy (CRP). " 05/01/2021 - "Specifically, updated knowledge regarding the neuroimaging patterns of the following diseases is summarized: sporadic Creutzfeldt-Jakob disease, neuronal intranuclear inclusion disease, and hereditary diffuse leukoencephalopathy with axonal spheroids-colony-stimulating factor receptors/adult-onset leukoencephalopathy with axonal spheroids and pigmented glia. " 02/01/2019 - "Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an adult-onset autosomal dominant leukoencephalopathy resulting from mutations affecting the tyrosine kinase domain of the colony stimulating factor receptor 1 protein (encoded by CSF1R). "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/01/1989 - "Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response." 03/29/1996 - "The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family." 03/01/1996 - "These results demonstrate that C/EBP and AML1 are important factors for regulating a critical hematopoietic growth factor receptor, the M-CSF receptor, suggesting a mechanism of how the AML1 fusion protein could contribute to acute myeloid leukemia. "
5.	Myeloproliferative Disorders (Myeloproliferative Disorder) 04/01/2007 - "A common point mutation in the JAK2 tyrosine kinase leads to constitutive hematopoietic growth factor receptor signaling and was recently described in many patients with myeloproliferative disorders (MPDs). " 06/01/2006 - "Recently, several groups identified a recurrent somatic point mutation constitutively activating the hematopoietic growth factor receptor-associated JAK2 tyrosine kinase in diverse chronic myeloid disorders - most commonly classic myeloproliferative disorders (MPD), especially polycythemia vera. "

Related Drugs and Biologics

1.	Macrophage Colony-Stimulating Factor
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	Cytokines
4.	Thrombopoietin (c-mpl Ligand)
5.	Proteins (Proteins, Gene)
6.	ErbB Receptors (EGF Receptor)
7.	Janus Kinases
8.	Toll-Like Receptor 7
9.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
10.	MicroRNAs (MicroRNA)

Related Therapies and Procedures

1.	Therapeutics