Free Radical Scavengers

Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.

Also Known As:

Networked: 476 relevant articles (38 outcomes, 65 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Maihöfner, C: 3 articles (06/2014 - 06/2007)
2.	Lin, Mao-Tsun: 3 articles (03/2013 - 01/2006)
3.	Miller, Josef M: 2 articles (01/2015 - 05/2007)
4.	Chen, Sheng-Hsien: 2 articles (03/2013 - 08/2006)
5.	Chang, Ching-Ping: 2 articles (03/2013 - 01/2006)
6.	De Cock, K: 2 articles (12/2008 - 02/2007)
7.	Vertriest, S: 2 articles (12/2008 - 02/2007)
8.	Vanderstraeten, G G: 2 articles (12/2008 - 02/2007)
9.	Van Maele, G: 2 articles (12/2008 - 02/2007)
10.	Rimbaut, S: 2 articles (12/2008 - 02/2007)

Related Diseases

1.	Ischemia 03/01/1998 - "Free radical scavengers are not likely to be effective in prevention of equine colonic mucosal deterioration after ischemia." 01/01/2005 - "Experimental studies of the use of free radical scavengers in ischemic/reperfusion (I/R) injury following detorsion of the torted testis have yielded conflicting results due to differences in the period of ischemia used. " 02/01/1992 - "Our study evaluated the activity and effect of free radical scavengers delivered systemically during the ischemic interval to an ischemia/reperfusion rat intestinal model. " 09/01/2002 - "Therefore, our investigations studied the influence of ischemia on energy fuels, on some natural free radical scavengers, and the relationship between the changes of these parameters in brain and blood. " 08/07/2000 - "Taken together, these results clearly demonstrate that oxidative stress developed in the ischemic reperfused myocardium induces apoptosis and free radical scavengers can play a crucial role in apoptotic cell death associated with ischemia/reperfusion."
2.	Brain Ischemia (Cerebral Ischemia) 01/01/2000 - "Protective effects of NOS inhibitors and free radical scavengers in cerebral ischemia are well documented. " 02/01/1989 - "We studied the protective effect of these free radical scavengers on ischemic brain injury using a rat model of focal cerebral ischemia, which is suitable for therapeutic trials. " 03/01/1997 - "Ca2+ entry blockers are generally not effective in cerebral ischemia, and data with protective effects of oxygen free radical scavengers in the post-ischemic period have shown conflicting results. " 05/01/2002 - "The present study indicates that anticoagulants and free radical scavengers reciprocally function to inhibit the progression of ischemic cell damage and that a combination of these types of drugs will help to improve the outcomes after cerebral ischemia." 05/01/2000 - "Neuroprotection by 2-h postischemia administration of two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia."
3.	Necrosis 12/01/1994 - "The results show significant reduction of myocardial necrosis by beta-adrenoceptor-blocking agents and free-radical scavengers during stress-induced increased sympathetic activity." 03/01/1994 - "Necrosis score on pathology was highest in group 3; this score also was higher than that in group 5 with free radical scavengers added (3.0 +/- 0.3 versus 2.0 +/- 0.4, P = 0.07) and higher than that of group 2 with reperfusion with buffer only (3.0 +/- 0.3 versus 1.4 +/- 0.5, P < 0.05). " 03/01/1988 - "Although postischemic necrosis and increased vascular permeability have been attenuated with the addition of free radical scavengers, no unequivocal chemical evidence for free radical injury in skeletal muscle is available. " 09/01/1987 - "Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism." 04/01/2009 - "Various free radical scavengers have been shown to prevent chemotherapy-induced skin necrosis. "
4.	Myocardial Stunning (Stunned Myocardium) 08/01/1987 - "Free radical scavengers improve functional recovery of stunned myocardium in a model of surgical coronary revascularization." 07/01/1992 - "Inhibiting free radical accumulation during myocardial ischemia/reperfusion with free radical scavengers and inhibitors has been demonstrated to reduce the severity of myocardial stunning, irreversible injury, and reperfusion arrhythmias in many, but not all, studies. " 10/01/1991 - "Although the fundamental mechanism(s) responsible for myocardial stunning has not been elucidated, in experimental preparations calcium antagonists, free-radical scavengers, and neutrophil depletion have each been found to be helpful in minimizing it." 10/01/1989 - "In the case of myocardial stunning, the phenomenon may be mediated, at least in part, by a burst of free radicals formed within the first minute of reperfusion and improved by free radical scavengers given at the time of reperfusion. " 11/01/1989 - "Whether oxygen free radical scavengers administered only during reperfusion enhance recovery of stunned myocardium in models of brief ischemia remains to be determined. "
5.	Wounds and Injuries (Trauma) 08/01/1992 - "Recent studies have demonstrated that free radical scavengers could afford protection to the mature myocardium from these injuries. " 06/27/2001 - "Pretreatment of the donor tissue with free-radical scavengers reduces cell loss caused by tissue trauma. " 11/01/2005 - "Tissue culture and animal model studies show that treatments with anti-oxidants and free radical scavengers reduce Ox/CaOx crystal induced injuries. " 05/01/2012 - "Captopril, acts as free radical scavengers and protect against injuries from oxidative damage to tissues.The" 11/01/2011 - "Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediated injuries. "

Related Drugs and Biologics

1.	Oxygen
2.	Superoxide Dismutase
3.	Antioxidants
4.	Catalase
5.	Free Radicals
6.	Dimethyl Sulfoxide (DMSO)
7.	Mannitol (Osmitrol)
8.	Vasodilator Agents (Vasodilators)
9.	Calcium
10.	Polyethylene Glycols (Polyethylene Glycol)

Related Therapies and Procedures

1.	Radiotherapy
2.	Ligation
3.	Induced Heart Arrest (Cardioplegia)
4.	Sutures (Suture)
5.	Heart Transplantation (Grafting, Heart)