Tumor Suppressor Protein p53

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

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Networked: 537 relevant articles (5 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Oren, Moshe: 4 articles (08/2007 - 09/2002)
2.	Selivanova, Galina: 4 articles (01/2007 - 02/2002)
3.	Kelsey, Karl T: 4 articles (11/2005 - 07/2005)
4.	Lu, Wuyuan: 3 articles (11/2015 - 04/2010)
5.	Kaul, Sunil C: 3 articles (07/2015 - 01/2009)
6.	Wadhwa, Renu: 3 articles (07/2015 - 01/2009)
7.	Yamada, Tohru: 3 articles (01/2014 - 10/2002)
8.	Rotter, Varda: 3 articles (01/2013 - 11/2004)
9.	Li, Chong: 3 articles (04/2012 - 04/2010)
10.	Kaiser, Peter: 3 articles (10/2011 - 09/2009)

Related Diseases

1.	Neoplasms (Cancer) 09/01/1999 - "The p53 tumor suppressor protein is a pivotal molecule in the protection against carcinogenesis and is inactivated in a plethora of human neoplasms, p53 prevents the accumulation of genomic alterations by inducing cell-cycle arrest or programmed cell death in response to genotoxic signals such as DNA damage and stress. " 06/01/1998 - "The tumor suppressor protein p53 plays a pivotal role in protection against the development of cancer and is inactivated in many human malignancies. " 07/01/2008 - "The present study was designed to investigate the expression pattern of KAI-1 in the normal endometrium and uterine tumors and to correlate it with the expression of tumor suppressor protein p53. " 10/04/2001 - "The p53 tumor suppressor protein is mutated in more than 50% of all human cancers, which makes the study of its functions and activities critical for the understanding and management of cancer. " 12/01/2015 - "The p53 tumor suppressor protein plays a critical role in cellular stress and cancer prevention. "
2.	Glioma (Gliomas) 08/15/2004 - "Here, we evaluated the conditionally replicative adenovirus AdDelta24 and its recently developed derivative AdDelta24-p53, which expresses functional p53 tumor suppressor protein while replicating in cancer cells, for treatment of malignant glioma. " 11/01/1996 - "High variability of the oncoprotein p53 immunoreactivity is characteristic of glioblastomas this suggesting genotypic polymorphism of gliomas of high grade malignancy. " 12/15/2003 - "Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells." 08/15/2014 - "Action mechanism studies indicated that the enhanced efficacy of the multifunctional targeting drugs-loaded liposomes could be due to the following aspects: evading the rapid elimination from blood circulation; crossing the BBB effectively; improving drug uptake by glioma cells and GSCs; down-regulating the overexpressed ABC transporters; inducing apoptosis of GSCs via up-regulating apoptotic receptor/ligand (Fas/Fasl), activating apoptotic enzymes (caspases 8, 9 and 3), activating pro-apoptotic proteins (Bax and Bok), activating tumor suppressor protein (P53) and suppressing anti-apoptotic proteins (Bcl-2 and Mcl-1). "
3.	T-Cell Lymphoma (Lymphoma, T Cell) 08/03/2010 - "This synthetic lethal interaction is attributable to inhibition of aurora-B kinase, with consequent disabling of the chromosomal passenger protein complex (CPPC) and ensuing DNA replication in the absence of cell division; executed by sequential apoptosis and autophagy; not reliant on the tumor suppressor protein p53; and effective against mouse models for B-cell and T-cell lymphomas initiated by transgenes of MYC. "
4.	Parkinson Disease (Parkinson's Disease) 11/01/2002 - "We report that two novel synthetic inhibitors of the tumor suppressor protein p53, pifithrin-alpha (PFT-alpha) and Z-1-117, are highly effective in protecting midbrain dopaminergic neurons and improving behavioral outcome in a mouse model of Parkinson's disease. "
5.	Carcinoma (Carcinomatosis) 02/09/2004 - "We conducted the present study to evaluate the frequency and prognostic importance on long-term survival of TP53 mutations and TP53 protein accumulation in a cohort of 178 patients with early-stage ovarian carcinomas. " 06/01/1993 - "The expression of p53 antigen in primary malignant epithelial tumors of the liver: an immunohistochemical study." 12/28/2014 - "To examine the effect of tumor suppressor protein p53 on the antitumor activity of 2- methoxyestradiol (2-MeO-E2), 2-MeO-E2-induced cell cycle changes and apoptotic events were compared between the human colon carcinoma cell lines HCT116 (p53(+/+)) and HCT116 (p53(-/-)). " 12/01/2013 - "From these data, we argue that tumoral FOXP3 has a potential oncogenic function in conjunction with the p53 tumor suppressor protein and infiltrated Tregs in human breast carcinomas." 12/01/2013 - "Tumoral FOXP3 has potential oncogenic function in conjunction with the p53 tumor suppressor protein and infiltrated Tregs in human breast carcinomas."

Related Drugs and Biologics

1.	Enzymes
2.	Apoptosis Regulatory Proteins
3.	Caspases
4.	ATP-Binding Cassette Transporters (ABC Transporters)
5.	Liposomes (Liposome)
6.	Z-1-117
7.	pifithrin
8.	aurora kinase (aurora A kinase)
9.	Antibodies
10.	Antigens

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Angioplasty (Angioplasty, Transluminal)
5.	Carotid Endarterectomy