Oligohydramnios

A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.

Networked: 516 relevant articles (18 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fetal Distress
2.	Acidosis
3.	Rupture
4.	Prolonged Pregnancy
5.	Pre-Eclampsia (Preeclampsia)

Experts

1.	Gribouval, Olivier: 6 articles (02/2014 - 09/2005)
2.	Antignac, Corinne: 5 articles (02/2014 - 09/2005)
3.	Gubler, Marie-Claire: 5 articles (02/2014 - 03/2008)
4.	Zhu, Xue-Qiong: 4 articles (08/2014 - 12/2012)
5.	Corvol, Pierre: 4 articles (02/2014 - 08/2006)
6.	Chen, Chung-Ming: 4 articles (04/2013 - 01/2007)
7.	Wang, Leng-Fang: 4 articles (04/2013 - 01/2007)
8.	Chou, Hsiu-Chu: 4 articles (04/2013 - 01/2007)
9.	Gubler, Marie Claire: 4 articles (02/2012 - 09/2005)
10.	Milnerowicz-Nabzdyk, E: 4 articles (01/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Oligohydramnios:

1.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2002 - "Inhaled nitric oxide for oligohydramnios-induced pulmonary hypoplasia: a report of two cases and review of the literature." 01/01/2011 - "To demonstrate the efficacy of early continuous positive airway pressure (CPAP) combined with inhaled nitric oxide (iNO) for treatment of preterm infants with lung hypoplasia and persistent foetal circulation (PFC) due to very early PPROM and prolonged severe oligohydramnios. " 02/01/2004 - "Nitric oxide inhalation therapy in very low-birthweight infants with hypoplastic lung due to oligohydramnios." 04/01/2009 - "We sought to determine if inhaled nitric oxide (iNO) administered to preterm infants with premature rupture of membranes (PPROM), oligohydramnios, and pulmonary hypoplasia improved oxygenation, survival, or other clinical outcomes. " 04/01/2009 - "Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia."
2.	Dinoprostone (PGE2)FDA Link 05/01/2014 - "(MCA) in 117 patients (27 associated with oligohydramnios) just before and 6 h after the administration of Dinoprostone. " 01/01/2007 - "138 women with uncomplicated oligohydramnios at term [amniotic fluid index (AFI) < or =5 cm] and a low Bishop score (< or =6) underwent induction of labor with prostaglandin E2. " 01/01/2007 - "Prostaglandin E2 induction of labor for isolated oligohydramnios in women with unfavorable cervix at term." 01/01/2000 - "Intracervical PGE2 appeared to effectively stimulate cervical ripening and labor induction in oligohydramnios, without causing side effects to the uterus and fetus." 01/01/2000 - "Use of prostaglandin E2 for cervical ripening in pregnancies with oligohydramnios."
3.	Sodium Chloride (Saline Solution)FDA LinkGeneric 09/01/1993 - "2. Saline solution amnioinfusion was effective in relieving oligohydramnios in all cases. " 03/01/1990 - "Amnioinfusion of 250 ml of normal saline solution was performed in 30 laboring women at greater than or equal to 37 weeks' gestation with oligohydramnios as defined by an amniotic fluid index of less than or equal to 5 cm. A total of 50 amnioinfusions were performed. " 07/01/1989 - "To avoid unfavorable effects of oligohydramnios on fetal development and well-being, we infused physiologic saline solution continuously into the amniotic cavity at a flow rate of 10 to 20 ml/hr with a new cervical indwelling catheter (PROM-fence). " 04/01/2000 - "Two fetuses with gastroschisis and severe oligohydramnios were treated antenatally with amnioinfusion of saline solution. " 09/01/1993 - "Saline solution amnioinfusion was performed for 12 cases of preterm PROM before 27 weeks gestational age complicated by oligohydramnios in order to suppress chorioamnionitis, prevent fetal pulmonary hypoplasia and delay delivery. "
4.	Dexamethasone (Maxidex)FDA LinkGeneric 10/01/2007 - "The purpose of the present study was to examine the effect of maternal dexamethasone treatment the expression of lamellar body in type II pneumocytes of the fetal rabbit lungs with hypoplasia induced by oligohydramnios using electron microscopy. " 10/01/2007 - "Effect of maternal dexamethasone treatment on the type II pneumocytes in hypoplastic lung by oligohydramnios: an ultrastructural study." 10/01/2007 - "These results suggest that maternal dexamethasone treatment accelerates the maturation of the surfactant system, especially the expression of lamellar bodies in type II pneumocytes, even in hypoplastic lungs induced by oligohydramnios." 10/01/1996 - "The results suggest that maternal dexamethasone treatment accelerates the functional development of alveolar type II cells in SP-A expression, even in hypoplastic lungs induced by oligohydramnios." 07/01/2004 - "In addition, the first-degree heart block resolved completely after only 2 weeks of dexamethasone treatment, and the heart rhythm remained stable throughout the remainder of the pregnancy despite early discontinuation of therapy due to oligohydramnios."
5.	Allanson Pantzar McLeod syndromeIBA 01/01/1989 - "Renal tubular dysgenesis: delayed onset of oligohydramnios." 01/01/2009 - "Autosomal recessive renal tubular dysgenesis (RTD) is a clinical disorder observed in fetuses, characterized by absence or poor development of proximal tubules and early onset and persistent oligohydramnios leading to the Potter sequence, associated with skull ossification defect. " 08/01/2006 - "Renal tubular dysgenesis is a clinical disorder that is observed in fetuses and characterized by the absence or poor development of proximal tubules, early onset and persistent oligohydramnios that leads to the Potter sequence, and skull ossification defects. " 08/01/2006 - "Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: Role of the Renin-Angiotensin system." 09/01/1997 - "Renal tubular dysgenesis: a cause of second trimester oligohydramnios."
6.	Hemoglobins (Hemoglobin)IBA 12/01/2011 - "Intrauterine exchange transfusion improved hemoglobin parameters, fetal growth, and oligohydramnios. " 06/01/1997 - "In three cases the hemoglobin concentration of the smaller twin with oligohydramnios was lower than the normal mean for gestation, and the hemoglobin difference was more than 5 g/dl in two of these cases. " 03/01/2013 - "There is a typical oligohydramnios/polyhydramnios sequence in the TTTS syndrome, whereas TAPS is characterized by large inter-twin hemoglobin difference in the absence of amniotic fluid discordances. " 06/01/1997 - "In the other two cases, the hemoglobin concentration of the four fetuses with coexistent oligohydramnios-polyhydramnios was within the normal range. " 06/01/1997 - "This suggests that twin-to-twin transfusion may occur without hemoglobin changes, or that alternatively coexistent oligohydramnios-polyhydramnios occurs in the absence of twin-to-twin transfusion."
7.	Terbutaline (Brethaire)FDA LinkGeneric 09/01/1992 - "Amnioinfusion resulted in no statistically significant reduction in the incidence of recurrent variable decelerations/bradycardia (26.3% vs. 46.6%), intrapartum resuscitation with terbutaline (5.2% vs. 10.0%), cesarean section for fetal distress (9.5% vs. 9.3%), fetal-acidosis (10.5% vs. 12.0%) or Apgar scores < 7 at five minutes (5.2% vs. 0%) in patients with oligohydramnios." 10/01/1993 - "Patients receiving indomethacin were converted to terbutaline at 34 weeks or with the occurrence of fetal ductal constriction or oligohydramnios. " 06/01/1991 - "After administration of indomethacin and terbutaline from 16 to 30 weeks' gestation, serial prenatal ultrasound examinations ultimately showed oligohydramnios in twin B and resolution of polyhydramnios in twin A. "
8.	SteroidsIBA 01/01/2004 - "Logistic regression analysis demonstrated that after taking into consideration successful amnioinfusion (P=0.019) and administration of steroids (P=0.022), none of the other variables, including gestational age at delivery, contributed significantly to the prediction of perinatal survival in the persistent oligohydramnios group. " 04/01/2003 - "Women who required systemic steroids were more likely to have oligohydramnios, intrauterine growth restricted infant, meconium staining, or pregnancy-induced hypertension. " 02/01/2014 - "After adjusting for the three hierarchical levels in the model for determination of death in the NICU up to the 27 th day of life, the following showed statistically significant association: type of delivery - cesarean section (OR = 0.72; 95%CI: 0.56-0.95), non-use of prenatal steroids (OR =1.51; 95%CI: 1.01-2.25), preeclampsia (OR = 0.73; 95%CI: 0.56-0.95), oligohydramnios (OR = 1.57; 95%CI: 1, 17-2.10), birth weight < 2500g (OR = 1.40; 95%CI: 1.03-1.90), 5-minute Apgar score < 7 (OR = 2.63; 95%CI: 2.21-3.14), endotracheal intubation (OR = 1.95; 95%CI: 1.31-2.91), and non-use of surfactant (OR = 0.54; 95%CI: 0.43-0.69). "
9.	Arginine Vasopressin (Argipressin)IBA 04/01/1996 - "Use of maternal 1-deamino-[8-D-arginine] vasopressin and oral fluid loading has the potential for manipulation of amniotic fluid volume homeostasis and may prove useful in the treatment of oligohydramnios." 05/01/1996 - "1-Deamino-[8-D-arginine] vasopressin therapy has potential for the prevention and treatment of oligohydramnios." 05/01/1996 - "Treatment of oligohydramnios with maternal 1-deamino-[8-D-arginine] vasopressin-induced plasma hypoosmolality." 05/01/1996 - "Pregnant women (n = 5) with oligohydramnios at term were administered oral water loading (20 ml/kg) and intravenous 1-deamino-[8-D-arginine] vasopressin (2 micrograms) to induce antidiuresis. "
10.	Sodium Bicarbonate (Baking Soda)FDA LinkGeneric 06/01/2006 - "Infusion into amniotic cavity and exchange of amniotic fluid is effective therapy for fetal distress due to oligohydramnios and can prevent meconium aspiration syndrome; infusion of antacids medicine (5% sodium bicarbonate) into amniotic cavity is effective and safe therapy for fetus with acidosis."

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 01/01/2009 - "In this study, the measure of pregnancy outcomes were mode of delivery, indications of caesarean section, percentage requiring caesarean section for foetal distress, oligohydramnios, meconium stained liquor, small placenta and cord around the neck. " 06/01/1995 - "AFI in this study ranged from 2.8 cm to 22.6 cm. The mean for 41 weeks was 13.52 +/- 4.6 cm and for 42 weeks, 9.93 +/- 4.37 cm. Oligohydramnios was noted in four patients, AFI less than 5.3 cm. Two of these cases developed intrapartum foetal distress and had Caesarean Section. " 10/01/1988 - "The incidence of induction of labor, of elective cesarean section, of preterm delivery (less than 37 weeks' gestation) was significantly higher in the oligohydramnios group (study group) as compared with the incidence in the control group (P less than 0.05). " 05/01/2015 - "We recorded primiparity (44.5%), multiple births (17.1%), vacuum-assisted delivery (6.2%), cesarean section (36.3%), oligohydramnios (4.1%), uterine abnormalities (2.1%), abnormal fetal position (3.4%), and intrauterine growth restriction (1.4%). " 09/01/2014 - "Nine patients (12.5%) had oligohydramnios; 50 (69.4%) delivered preterm (<37 weeks), and 26 underwent a cesarean section, of those 7 (29.2%) cesarean sections were for a nonreassuring fetal heart rate tracing. "
2.	Fetal Version (External Cephalic Version) 01/01/2002 - "Simple maternal hydration appears to increase amniotic fluid volume and may be beneficial in the management of oligohydramnios and prevention of oligohydramnios during labour or prior to external cephalic version. " 01/01/2000 - "Simple maternal hydration appears to increase amniotic fluid volume and may be beneficial in the management of oligohydramnios and prevention of oligohydramnios during labour or prior to external cephalic version. " 06/01/2005 - "When the fetus was found to be breech with oligohydramnios, amnioinfusion was performed to facilitate external cephalic version, and this successful procedure enabled the patient to deliver vaginally." 01/01/2002 - "Oligohydramnios (reduced amniotic fluid) may be responsible for malpresentation problems, umbilical cord compression, concentration of meconium in the liquor, and difficult or failed external cephalic version. " 01/01/2000 - "Oligohydramnios (reduced amniotic fluid) may be responsible for malpresentation problems, umbilical cord compression, concentration of meconium in the liquor, and difficult or failed external cephalic version. "
3.	Decompression 12/01/1997 - "Spontaneous (or therapeutic) intra-uterine decompression of the bladder might ameliorate obstructive nephropathy and oligohydramnios, allowing adequate lung development." 10/01/1991 - "Oligohydramnios was present in the other two of 11 fetuses despite successful decompression and they had markedly dysmorphic kidneys and profoundly hypoplastic and immature lungs (LV:BW 5.1 cc./kg.). " 05/01/1990 - "In 6 of the 8 survivors in the good prognosis group, severe oligohydramnios was reversed by decompression. " 12/01/1988 - "One had no amniotic fluid even after decompression, and the other had some amniotic fluid after decompression but a tiny chest cavity due to the long period of severe oligohydramnios before decompression. " 06/01/1987 - "We conclude that a fetal abdominal mass does not independently produce pulmonary hypoplasia, possibly because the "mass effect" is relieved by distension of the abdominal wall rather than elevation of the diaphragm; the pulmonary hypoplasia that occurs in bladder outlet obstruction is probably due to the associated oligohydramnios rather than the mass effect of the dilated urinary tract; and prenatal decompression of an abdominal mass or dilated urinary tract is not justified to prevent pulmonary hypoplasia in the absence of oligohydramnios."
4.	Resuscitation 11/01/1998 - "We observed a premature baby born after severe oligohydramnios who could not be ventilated efficiently even with very high pressures immediately after birth, but who, after cessation of resuscitation attempts, recovered spontaneous sufficient breathing during the following hour. " 05/01/1981 - "Problems with resuscitation should be anticipated in pregnancies complicated by prolonged leakage of amniotic fluid or oligohydramnios, and pulmonary hypoplasia should be recognized as a cause of respiratory distress. " 09/01/1992 - "Amnioinfusion resulted in no statistically significant reduction in the incidence of recurrent variable decelerations/bradycardia (26.3% vs. 46.6%), intrapartum resuscitation with terbutaline (5.2% vs. 10.0%), cesarean section for fetal distress (9.5% vs. 9.3%), fetal-acidosis (10.5% vs. 12.0%) or Apgar scores < 7 at five minutes (5.2% vs. 0%) in patients with oligohydramnios."
5.	Aftercare (After-Treatment) 01/01/2007 - "There was subjective improvement in amniotic fluid volume after treatment, but always within the criteria of oligohydramnios. " 11/01/1993 - "Eight had associated maternal oligohydramnios, of whom 6 presented prenatally and 2 postnatally: this factor was associated with a poor prognosis, with renal impairment persisting in 6 of these patients after treatment. " 05/01/1997 - "We report a patient with severe oligohydramnios that resolved after treatment of diabetes insipidus. "