Simian Acquired Immunodeficiency Syndrome

Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.

Also Known As:

Simian Acquired Immune Deficiency Syndrome; Simian Acquired Immuno-Deficiency Syndrome; AIDSs, Simian; Simian AIDSs; Simian Acquired Immuno Deficiency Syndrome; AIDS, Simian; SAIDS; Simian AIDS

Networked: 134 relevant articles (7 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Simian Acquired Immunodeficiency Syndrome
2.	Acquired Immunodeficiency Syndrome (AIDS)
3.	Infections
4.	Autoimmune Diseases (Autoimmune Disease)
5.	Disease Progression

Experts

1.	Yao, Qingping: 4 articles (08/2018 - 04/2016)
2.	Lewis, Mark G: 4 articles (07/2013 - 01/2006)
3.	Shen, Min: 3 articles (12/2019 - 07/2017)
4.	Franchini, Genoveffa: 3 articles (03/2013 - 09/2005)
5.	McClure, Harold M: 3 articles (01/2008 - 02/2004)
6.	Chuang, Linda F: 3 articles (05/2005 - 06/2002)
7.	Chuang, Ronald Y: 3 articles (05/2005 - 06/2002)
8.	Doi, Roy H: 3 articles (05/2005 - 06/2002)
9.	Suzuki, Shunji: 3 articles (05/2005 - 06/2002)
10.	Wang, Dong: 2 articles (01/2022 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Simian Acquired Immunodeficiency Syndrome:

1.	VaccinesIBA 01/01/2006 - "Improved vaccine protection from simian AIDS by the addition of nonstructural simian immunodeficiency virus genes." 12/01/2023 - "A diagnosis of SSc did not confer a higher risk of delayed post-COVID-19 vaccine-related ADEs overall compared with other SAIDs and HCs. " 01/10/2023 - "The main purpose of this review was to evaluate the scientific evidence available on both the efficacy and safety of vaccines in patients with SAIDs. " 01/10/2023 - "Current guidelines recommend the regular sequential administration of vaccines for all individuals with SAIDs. " 12/23/2022 - "Major AEs and hospitalizations (<2%) were comparable across vaccine types in SAIDs. "
2.	CytokinesIBA 01/01/2023 - "Trajectory analysis showed that inhibition of macrophage differentiation, rather than reduction of the inflammatory cytokines, as the potential mechanism of anti-TNF treatment response in SAIDs." 02/01/2019 - "The systemic autoinflammatory disorders (SAIDs) are associated with dysregulation of the innate immune system, affecting pro-inflammatory cytokines and apoptosis pathways. " 09/01/2015 - "Within the last decade, the use of cytokine-neutralizing therapies has been shown to improve the clinical symptoms of many patients with different sAIDs. " 09/01/2015 - "Rare systemic autoinflammatory diseases (sAIDs) are driven by cytokine-mediated uncontrolled inflammation that results from activation of innate immune pathways. " 11/01/2014 - "Plasma viral loads, cytokine expression levels and anti-SIV antibody levels were also assayed to acquire certain basic indexes to evaluate disease progression in the rhesus macaque SAIDS model. "
3.	SuspensionsIBA 05/01/1985 - "Experimental intraperitoneal inoculation with suspensions of RF tissue in two separate experiments resulted in the development of SAIDS in 5 of 16 and RF-SAIDS in 3 of 16 macaques. " 07/16/2013 - "Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS."
4.	SteroidsIBA 01/01/2016 - "First line treatment for SAIDs consisted mostly of steroid, with 85% of response. " 01/01/2015 - "To assess potential of preoperative therapy with local steroid and non-steroid anti-inflammatory drugs (SAIDs and NSAIDs) for prolonging the hypotensive effect of trabeculectomy. "
5.	AIDS VaccinesIBA 09/01/2007 - "All HIV vaccine strategies tested in neonatal macaques are immunogenic, but only a subset of these vaccines confer significant protection against virus acquisition or simian AIDS after oral challenge. "
6.	InterleukinsIBA 11/01/2015 - "Interleukin (IL)-6 blockade is frequently effective in inflammatory conditions, however, there are few published data on its use in AA amyloidosis or the systemic autoinflammatory diseases (SAIDs) or chronic inflammatory conditions. "
7.	Raltegravir Potassium FDA Link 03/16/2010 - "Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy."
8.	AA amyloidosisIBA 11/01/2015 - "Interleukin (IL)-6 blockade is frequently effective in inflammatory conditions, however, there are few published data on its use in AA amyloidosis or the systemic autoinflammatory diseases (SAIDs) or chronic inflammatory conditions. "
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 07/01/2011 - "Our in vitro study indicates that steroidal anti-inflammatory drugs (SAIDs) as well as nonsteroidal anti-inflammatory drugs (NSAIDs) have immunosuppressive effects on calf PBMCs. " 05/27/2016 - "In spite of their numerous beneficial effects, both SAIDs as well as NSAIDs have their independent, unavoidable side effects, which discourage their prolonged therapeutic applications. " 01/01/2013 - "Pharmacological validation of this optimized assay was performed with a panel of anti-inflammatory drugs, demonstrating a concentration-responsive inhibition of leukocyte migration for both steroidal and non-steroidal anti-inflammatory drugs (SAIDs and NSAIDs). " 09/13/2010 - "The use of NSAIDs, as for SAIDs, is associated with an increased risk of chronic AF. " 09/13/2010 - "Two separate nested case-control analyses estimated the risk of first-time chronic and paroxysmal AF among users of SAIDs and NSAIDs. "
10.	DNA (Deoxyribonucleic Acid)IBA 04/20/1984 - "Nucleic acid hybridization studies reveal that the origin of the SAIDS-D isolate may reside in Old World monkey (subfamily Colobinae) cellular DNA." 02/01/2019 - "To date more than 800 variants have been recorded on the Infevers database, an online repository for DNA changes in genes associated with SAIDs (http://fmf.igh.cnrs.fr/ISSAID/infevers/). " 02/01/2019 - "Thus, in making a referral for DNA screening, clinical information that supports the choice for screening of one or more SAIDs genes is required. " 04/25/2006 - "DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued." 08/01/2002 - "In contrast, animals that were inoculated with SIV at 11 weeks after RhCMV infection rarely exhibited RhCMV DNA in plasma, had low copy numbers of RhCMV DNA in most tissues, and did not develop early onset of SAIDS or activated RhCMV. "

Therapies and Procedures

1.	Therapeutics 01/01/2023 - "Good responses to anti-TNF therapy were observed in SAIDs patients. " 10/01/1995 - "A retrospective analysis of necropsies on 135 macaques with SIV-induced simian AIDS that received neither antiretroviral nor antimicrobial therapy revealed that 17% (23/135) were infected with MAC. " 03/16/2010 - "Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy." 09/01/2015 - "Within the last decade, the use of cytokine-neutralizing therapies has been shown to improve the clinical symptoms of many patients with different sAIDs. " 05/27/2016 - "Existing therapeutics targeting the inflammatory responses include steroidal antiinflammatory drugs (SAIDs) and nonsteroidal antiinflammatory drugs (NSAIDs). "
2.	Investigational Therapies (Experimental Therapy) 07/16/2013 - "Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS."
3.	Transjugular Intrahepatic Portasystemic Shunt 01/01/2018 - "This review is conceived as a practical template for proper classification of children with recurring fevers and includes tips useful for the diagnostic approach to SAIDs, focusing on the specific acute painful symptoms and hematologic manifestations encountered in childhood."
4.	Trabeculectomy (Trabeculoplasty) 01/01/2015 - "To assess potential of preoperative therapy with local steroid and non-steroid anti-inflammatory drugs (SAIDs and NSAIDs) for prolonging the hypotensive effect of trabeculectomy. "
5.	Intravenous Infusions 11/01/1989 - "Ten macaques naturally infected with simian acquired immunodeficiency syndrome retrovirus serotype 2 (SRV-2), the etiologic agent of simian acquired immunodeficiency syndrome, received ddC by continuous intravenous infusion or by a daily bolus injection for 10 to 12 days. "