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Immunodominant Epitopes

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Subunits of the antigenic determinant that are most easily recognized by the immune system and thus most influence the specificity of the induced antibody.

Also Known As:

Immunodominant Determinants; Immunodominant Domains; Immunodominant Regions; Immunodominant Sites; Determinants, Immunodominant; Determinants, Immunodominant Antigenic; Domains, Immunodominant; Immunodominant Antigenic Determinants; Immunodominant Antigens; Regions, Immunodominant; Sites, Immunodominant; Antigenic Determinants, Immunodominant; Antigens, Immunodominant; Epitopes, Immunodominant

Networked: 279 relevant articles (10 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 1315
- Antigens: 114404
  - Epitopes: 7952
    - Immunodominant Epitopes: 279

Experts

1.	Gardas, Andrzej: 4 articles (05/2011 - 05/2004)
2.	Maillere, Bernard: 3 articles (06/2015 - 01/2011)
3.	Altmann, Daniel M: 3 articles (06/2015 - 11/2006)
4.	Liang, Xiaowu: 3 articles (08/2014 - 05/2007)
5.	Felgner, Philip L: 3 articles (08/2014 - 05/2007)
6.	Gora, Monika: 3 articles (09/2012 - 07/2004)
7.	Banga, J Paul: 3 articles (05/2011 - 07/2004)
8.	Zarour, Hassane M: 3 articles (01/2011 - 05/2002)
9.	Laal, Suman: 3 articles (03/2010 - 11/2006)
10.	Reddehase, Matthias J: 2 articles (06/2015 - 11/2012)

Related Diseases

1.	Infection 03/17/2008 - "This study formally demonstrates in a mouse infection model that naturally occurring contraction of the naive T cell repertoire can result in impaired CD8 T cell responses to known immunodominant epitopes and decline in heterosubtypic immunity. " 06/01/2015 - "The initially insufficient T cell response to the immunodominant epitopes may play a role in influencing the severity of HTNV infection. " 06/01/2015 - "Functional deletion of the respective immunodominant epitopes (IDEs) in mutant virus Δ4IDE revealed a still efficient control of infection. " 05/01/2015 - "Whether immunodominant epitopes elicit protective CD8+ T cell responses or instead act as decoys to subvert immunity and allow pathogens to establish chronic infection is unknown. " 01/01/2015 - "Immunoproteomic identification of immunodominant antigens independent of the time of infection in Brucella abortus 2308-challenged cattle."
2.	Neoplasms (Cancer) 06/15/2010 - "In this study, we show that two immunodominant epitopes derived from the tumor Ags (TAs) NY-ESO-1 and TRAG-3 stimulate both CD4+ Th cells and Tregs. " 05/01/2002 - "Whether the immunodominant epitopes in B95.8 are shared in virus from tumors will affect the general applicability of this therapy. " 03/15/2007 - "Here, we show that CD8+ T cells are critical for the efficacy of intratumoral vesicular stomatitis virus virotherapy and are induced against both virally encoded and tumor-associated immunodominant epitopes. " 05/01/2004 - "We report here that T cell lines generated from lymphoma patients actively immunized with idiotype protein specifically recognized multiple, unique immunodominant epitopes in autologous tumor idiotype. " 02/01/2003 - "The immunodominant epitopes identified will be useful in the design of peptide-based cancer vaccines and in the study of the functional state of tumor-specific CD4(+) T cells in patients bearing tumors expressing MAGE-3."
3.	Tuberculosis (Tuberculoses) 09/01/2013 - "tuberculosis immunodominant antigens in Streptomyces lividans and their subsequent downstream processing. " 04/01/2012 - "In order to identify immunodominant antigens of Mycobacterium tuberculosis that may be used in the serodiagnosis of active tuberculosis (TB), we designed an M. " 05/21/2010 - "Tuberculosis remains a major human health problem worldwide, and strategies for its prevention include the generation and characterization of new recombinant vaccines containing immunodominant antigens from Mycobacterium tuberculosis. " 03/01/2010 - "Antibodies against immunodominant antigens of Mycobacterium tuberculosis in subjects with suspected tuberculosis in the United States compared by HIV status." 01/01/2008 - "tuberculosis Malate Synthase (MS) and MPT51 as immunodominant antigens in TB patients. "
4.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/01/1989 - "The availability of recombinant autoantigens will provide improved diagnostic tests and, more importantly, will allow definite issues in primary biliary cirrhosis to be studied, including identification of immunodominant epitopes, the significance of autoantigen recognition and the establishment of autoreactive T cell clones." 03/01/1992 - "We have taken advantage of the antigenic mapping studies of both primary biliary cirrhosis and branched chain 2-oxo-acid dehydrogenase complex E2 subunits and designed a molecule that expresses the immunodominant epitopes of both. " 11/01/1990 - "Moreover, in those patients showing reactivity with mitochondrial antigens, the autoantibodies were directed at the same immunodominant epitopes that have been previously characterized in primary biliary cirrhosis. "
5.	Autoimmune Diseases (Autoimmune Disease) 10/01/2005 - "Detection and modulation of effector T cells specific to immunodominant epitopes is a central issue in autoimmune diseases. " 11/15/1997 - "Determination of immunodominant epitopes of MHC class I-restricted self-Ags and elucidation of TCR contact residues is of potential importance in providing a means of manipulating the immune response to self-Ags in human autoimmune diseases. " 04/01/2013 - "These findings implicate immunodominant epitopes in the pathology of ANCA-associated vasculitis and suggest that autoantibody diversity may be common to other autoimmune diseases." 09/27/2005 - "Although multiple sclerosis (MS) is thought to be an autoimmune disease, the mechanisms by which immunodominant epitopes are generated and lymphocytes are activated are not known. " 01/01/2011 - "T cell-dependent autoimmune diseases are characterized by the expansion of T cell clones that recognize immunodominant epitopes on the target antigen. "

Related Drugs and Biologics

1.	Antigens
2.	Proteins (Proteins, Gene)
3.	Antibodies
4.	Membrane Proteins (Integral Membrane Proteins)
5.	Autoantigens
6.	Flagellin
7.	Surface Antigens (Surface Antigen)
8.	Toll-Like Receptor 2
9.	Peptide Fragments
10.	Epitopes

Related Therapies and Procedures

1.	Mucosal Administration
2.	Immunotherapy
3.	Transplants (Transplant)
4.	Plasmapheresis
5.	Microspheres (Microsphere)