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Zalcitabine (Hivid)

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Also Known As:
Hivid; 2',3' Dideoxycytidine; HIVID Roche; NSC-606170; NSC 606170; NSC606170; 2',3'-Dideoxycytidine; Dideoxycytidine; ddC (Antiviral); Cytidine, 2',3'-dideoxy-
Networked: 278 relevant articles (14 outcomes, 44 trials/studies)

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Drug Context: Research Results

Experts

1. Levine, Jon D: 6 articles (08/2011 - 01/2004)
2. Walker, Ulrich A: 6 articles (12/2010 - 11/2002)
3. Kirschner, Janbernd: 4 articles (12/2010 - 01/2007)
4. Lebrecht, Dirk: 4 articles (12/2010 - 01/2007)
5. Venhoff, Nils: 4 articles (12/2010 - 11/2002)
6. Masocha, Willias: 3 articles (12/2019 - 01/2017)
7. Hao, Shuanglin: 3 articles (07/2014 - 11/2011)
8. Liu, Shue: 3 articles (07/2014 - 11/2011)
9. Ripsch, Matthew S: 3 articles (03/2013 - 07/2007)
10. White, Fletcher A: 3 articles (03/2013 - 07/2007)

Related Diseases

1. Acquired Immunodeficiency Syndrome (AIDS)
2. HIV Infections (HIV Infection)
3. Disease Progression
4. AIDS-Related Complex (ARC)
5. Peripheral Nervous System Diseases (PNS Diseases)

Related Drugs and Biologics

1. Zidovudine (Retrovir)
2. Didanosine (Videx)
3. Zalcitabine (Hivid)
4. Ritonavir (Norvir)
5. Saquinavir (Invirase)
6. Antigens
7. Antiviral Agents (Antivirals)
8. Biomarkers (Surrogate Marker)
9. 2',3'-dideoxycytidine 5'-triphosphate
10. Nucleosides

Related Therapies and Procedures

1. Therapeutics
2. Oral Administration
3. First Aid (Aids, First)
4. Aftercare (After-Treatment)
5. Highly Active Antiretroviral Therapy (HAART)