Trichosanthin

Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of Trichosanthes kirilowii. It has been used as an abortifacient and in the treatment of trophoblastic tumors. GLQ223 (Compound Q), a highly purified form of trichosanthin, has been proposed as antiviral treatment for AIDS.

Also Known As:

Networked: 119 relevant articles (7 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Yongzhuo: 7 articles (11/2021 - 01/2017)
2.	Zhang, Meng: 6 articles (11/2021 - 01/2017)
3.	Chen, Yingzhi: 5 articles (11/2021 - 01/2017)
4.	Tang, Yisi: 5 articles (11/2021 - 01/2017)
5.	Wu, Aihua: 5 articles (11/2021 - 01/2017)
6.	Xu, Qin: 5 articles (11/2021 - 01/2017)
7.	Sha, Ou: 4 articles (03/2021 - 06/2013)
8.	Wang, Ping: 4 articles (01/2013 - 09/2007)
9.	Li, Ji-Cheng: 4 articles (06/2010 - 09/2007)
10.	Huang, Yiling: 3 articles (04/2022 - 10/2012)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2014 - "Among these genes, trichosanthin (TCS) gene yielded the most promising results for the inhibition of cancer cell growth in vitro. " 07/01/2011 - "Trichosanthin (TCS), extracted from the Chinese medicinal herb Trichosanthes kirilowi, has shown promise for the inhibition of tumor growth. " 04/01/2019 - "Previous studies have indicated that Trichosanthin (TCS) exerts anti-virus, immunoregulation and a broad spectrum anti-tumor pharmacological activities. " 01/01/2019 - "Studies have suggested trichosanthin (TCS) exerts antitumor activity mainly through direct cytotoxicity toward cancer cells and immune regulation. " 01/01/2023 - "Trichosanthin is an approved gynecology drug in China and its immunomodulatory effects have drawn much attention as an old drug for new applications in cancer. "
2.	HIV Infections (HIV Infection) 12/01/1990 - "Further studies are indicated to determine pharmacodynamic properties of GLQ223, its optimal dosing schedule, and whether GLQ223 or related molecules will be useful in the treatment of HIV infection." 12/01/1990 - "Trichosanthin, imported from China, is the active drug in community-initiated treatment programs for patients with HIV infection. " 04/01/1989 - "The anti-HIV activity of GLQ223 in both acutely and chronically infected cells and its activity in cells of both lymphoid and mononuclear phagocytic lineage make it an interesting candidate as a potential therapeutic agent in HIV infection and AIDS." 07/05/1999 - "Trichosanthin (TCS), an active protein component isolated from a traditional Chinese medicinal herb Trichosanthes kirilowii, has been shown to inhibit HIV infection and has been applied in clinical treatment of AIDS. " 02/01/1992 - "Twenty patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC) or asymptomatic HIV infection (HIV+) were given 20 mcg kg-3 trichosanthin (TCS; 'Compound Q'), a ribosome-inactivating protein with in vitro antiviral activity against human immunodeficiency virus (HIV) once every four weeks for up to 12 weeks. "
3.	Herpes Simplex 09/01/2011 - "Conversion of trichosanthin-induced CD95 (Fas) type I into type II apoptotic signaling during Herpes simplex virus infection." 06/01/2006 - "[Protective effects of trichosanthin in Herpes simplex virus-1 encephalitis in mice]."
4.	Cicatrix (Scar) 01/01/2015 - "Trichosanthin benefits the treatment of caesarean scar pregnancies." 01/01/2015 - "This retrospective study aimed to assess the efficacy of trichosanthin (TCS) in combination with or without uterine arteries embolisation (UAE), uterine curettage and sac aspiration for the treatment of caesarean scar pregnancies (CSPs). " 01/01/2016 - "Trichosanthin has been found to be useful for treatment of cesarean scar pregnancies and ectopic pregnancy, and for preventing acute rejection of major histocompatibility complex-mismatched mouse skin allograft. "
5.	Trophoblastic Neoplasms (Trophoblastic Tumor) 11/01/1976 - "In summary, trichosanthin, a plant protein discovered from Chinese medicinal herbs, is a drug effective in abortion induction and against trophoblastic neoplasms. "

Related Drugs and Biologics

1.	Plant Proteins
2.	Proteins (Proteins, Gene)
3.	Saporins
4.	Antiviral Agents (Antivirals)
5.	Calcium
6.	Enzymes
7.	aluminum sulfate (alum)
8.	Trichosanthin
9.	Cell-Penetrating Peptides
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Curettage
2.	Immunotherapy
3.	Intravenous Infusions
4.	Therapeutics
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)