Trichosanthin

Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of Trichosanthes kirilowii. It has been used as an abortifacient and in the treatment of trophoblastic tumors. GLQ223 (Compound Q), a highly purified form of trichosanthin, has been proposed as antiviral treatment for AIDS.

Also Known As:

Networked: 78 relevant articles (6 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Ping: 4 articles (01/2013 - 09/2007)
2.	Li, Ji-Cheng: 4 articles (06/2010 - 09/2007)
3.	Huang, Liming: 3 articles (02/2015 - 09/2011)
4.	Huang, Hai: 3 articles (08/2006 - 11/2002)
5.	Wang, Yanlin: 2 articles (02/2015 - 09/2011)
6.	Huang, Yiling: 2 articles (02/2015 - 10/2012)
7.	Cui, Lei: 2 articles (02/2015 - 10/2012)
8.	Wang, Yuan: 2 articles (11/2014 - 08/2009)
9.	He, Dongxu: 2 articles (01/2013 - 09/2011)
10.	Tam, Siucheung: 2 articles (01/2013 - 09/2011)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2014 - "Among these genes, trichosanthin (TCS) gene yielded the most promising results for the inhibition of cancer cell growth in vitro. " 07/01/2011 - "Trichosanthin (TCS), extracted from the Chinese medicinal herb Trichosanthes kirilowi, has shown promise for the inhibition of tumor growth. " 10/01/2012 - "In this study, we investigated the demethylation activity of trichosanthin (TCS, the main bioactive component isolated from a Chinese medicinal herb) and its possible mechanism of action in cervical cancer cell lines. " 02/01/2015 - "Smac is another pathway in the anti-tumour activity of Trichosanthin and reverses Trichosanthin resistance in CaSki cervical cancer cells." 01/11/2013 - "Trichosanthin (TCS) is a type I ribosome-inactivating protein that has anti-tumor activity, but the underlying mechanism remains unclear. "
2.	HIV Infections (HIV Infection) 12/01/1990 - "Further studies are indicated to determine pharmacodynamic properties of GLQ223, its optimal dosing schedule, and whether GLQ223 or related molecules will be useful in the treatment of HIV infection." 12/01/1990 - "Trichosanthin, imported from China, is the active drug in community-initiated treatment programs for patients with HIV infection. " 07/05/1999 - "Trichosanthin (TCS), an active protein component isolated from a traditional Chinese medicinal herb Trichosanthes kirilowii, has been shown to inhibit HIV infection and has been applied in clinical treatment of AIDS. " 04/01/1989 - "The anti-HIV activity of GLQ223 in both acutely and chronically infected cells and its activity in cells of both lymphoid and mononuclear phagocytic lineage make it an interesting candidate as a potential therapeutic agent in HIV infection and AIDS." 02/01/1992 - "Twenty patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC) or asymptomatic HIV infection (HIV+) were given 20 mcg kg-3 trichosanthin (TCS; 'Compound Q'), a ribosome-inactivating protein with in vitro antiviral activity against human immunodeficiency virus (HIV) once every four weeks for up to 12 weeks. "
3.	Hydatidiform Mole (Molar Pregnancy) 03/01/1990 - "During 1972-1986, 44 of 52 patients (84.6%) with hydatidiform mole were treated successfully with trichosanthin. " 03/01/1990 - "Trichosanthin in the treatment of hydatidiform mole. "
4.	Herpes Simplex 06/01/2006 - "[Protective effects of trichosanthin in Herpes simplex virus-1 encephalitis in mice]."
5.	Encephalitis (Encephalitis, Rasmussen) 06/01/2006 - "[Protective effects of trichosanthin in Herpes simplex virus-1 encephalitis in mice]."

Related Drugs and Biologics

1.	Calcium
2.	aluminum sulfate (alum)
3.	Trichosanthin
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Proteins (Proteins, Gene)
6.	DNA (Deoxyribonucleic Acid)
7.	p38 Mitogen-Activated Protein Kinases
8.	Anti-Retroviral Agents (Antiretroviral Agents)
9.	LDL-Receptor Related Protein 1 (LDL-Receptor Related Protein)
10.	Telomerase (Telomerase Reverse Transcriptase)

Related Therapies and Procedures

1.	Curettage
2.	Intravenous Infusions
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Salpingectomy
5.	Blood Transfusion (Blood Transfusions)