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Factor VIIIa

Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Also Known As:
Blood Coagulation Factor VIII, Activated; Factor 8A; Factor Eight A; Factor VIIIa Heavy Chain, 200 kDa Isoform; Factor VIIIa Heavy Chain, 92 kDa Isoform; Factor VIIIa Light Chain; Activated Factor VIII; Factor VIII, Thrombin Activated; Factor VIIIa, Coagulation; Thrombin-Activated Factor VIII; Coagulation Factor VIIIa; Factor VIII, Activated; Factor VIII, Thrombin-Activated; Blood-coagulation factor VIIIa, procoagulant
Networked: 44 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Shima, Midori: 3 articles (03/2021 - 01/2017)
2. Kitazawa, Takehisa: 2 articles (03/2021 - 01/2021)
3. Nogami, Keiji: 2 articles (03/2021 - 01/2021)
4. Shida, Yasuaki: 2 articles (03/2021 - 01/2021)
5. Yaoi, Hiroaki: 2 articles (03/2021 - 01/2021)
6. AlHammad, Fatimah Abbas: 1 article (03/2022)
7. AlOqab, Aysha Waheed: 1 article (03/2022)
8. Butt, Sohail A: 1 article (03/2022)
9. Bjelke, Mads: 1 article (01/2022)
10. Björkdahl, Olle: 1 article (01/2022)

Related Diseases

1. Hemophilia A (Haemophilia)
2. Autolysis
3. Acute-Phase Reaction
4. Activated Protein C Resistance (APC Resistance)
08/01/1995 - "To overcome the limitations of aPTT-based assays in the diagnosis of APC resistance, we have developed a chromogenic assay which is based on the capacity of APC to limit the generation of factor Xa by inactivating factor VIIIa in plasma. "
08/15/1994 - "We developed an amidolytic assay for the determination of APC-resistance by inhibition of factor Xa (F Xa) generation, expecting it to be a result of factor VIIIa (F VIIIa) inactivation. "
01/01/2001 - "Serum levels of modified activated protein C resistance, antithrombin III, fibrinogen, factor VIIIa, factor VIII, factor IX, activated partial thromboplastin time, prothrombin time, thrombin time, and lipoprotein (a) were measured before and 6 months after the treatment and analyzed for changes in extrinsic and intrinsic coagulation parameters. "
08/21/2006 - "The coagulations tests were performed including: prothrombin time, activated partial thromboplastic time (aPTT), fibrinogen, anticardiolipin antibodies, lupus anticoagulant, antithrombin, protein C and protein S activities, factor VIII, activated protein C (APC) resistance, factor V Leiden, and quantitative D-dimers. "
04/01/2008 - "Men in lower social classes had higher mean levels of C-reactive protein, fibrinogen, interleukin-6, white blood cell count, von Willebrand factor (vWF), factor VIII, activated protein C (APC) resistance, plasma viscosity, fibrin D-dimer and platelet count, compared to higher social class groups; but not of tissue plasminogen activator antigen, haematocrit or activated partial prothrombin time. "
5. Hemorrhage

Related Drugs and Biologics

1. Factor VIII (Coagulation Factor VIII)
2. emicizumab
3. Factor IXa (Coagulation Factor IXa)
4. Monoclonal Antibodies
5. Peptide Hydrolases (Proteases)
6. Protein S
7. Factor X (Stuart Factor)
8. Protein C
9. Fibrinogen (Factor I)
10. Factor Va

Related Therapies and Procedures

1. Salvage Therapy
2. Therapeutics