Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Also Known As:
Blood Coagulation Factor VIII, Activated; Factor 8A; Factor Eight A; Factor VIIIa Heavy Chain, 200 kDa Isoform; Factor VIIIa Heavy Chain, 92 kDa Isoform; Factor VIIIa Light Chain; Activated Factor VIII; Factor VIII, Thrombin Activated; Factor VIIIa, Coagulation; Thrombin-Activated Factor VIII; Coagulation Factor VIIIa; Factor VIII, Activated; Factor VIII, Thrombin-Activated; Blood-coagulation factor VIIIa, procoagulant