Complement Membrane Attack Complex (Membrane Attack Complex)

A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.

Also Known As:

Networked: 672 relevant articles (3 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rus, Horea: 14 articles (05/2013 - 12/2003)
2.	Morgan, B Paul: 12 articles (12/2014 - 01/2002)
3.	Niculescu, Florin: 11 articles (05/2013 - 12/2003)
4.	Cybulsky, Andrey V: 10 articles (11/2013 - 09/2002)
5.	Morgan, B P: 7 articles (08/2011 - 02/2000)
6.	Magro, Cynthia M: 6 articles (05/2015 - 11/2002)
7.	Wang, Yingwei: 6 articles (03/2014 - 06/2006)
8.	Takano, Tomoko: 6 articles (11/2013 - 09/2002)
9.	Cudrici, Cornelia: 6 articles (08/2011 - 01/2005)
10.	Couser, William G: 6 articles (11/2006 - 04/2002)

Related Diseases

1.	Inflammation 06/15/2011 - "Our data indicate that protection from ECM in C5(-/-) mice is mediated through inhibition of membrane attack complex formation and not through C5a-induced inflammation." 12/01/2004 - "Complement activation with formation of biologically potent mediators like C5a and the terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and tissue damage in a number of autoimmune and inflammatory conditions. " 12/01/2004 - "As markers of inflammation, the major histocompatibility complex (MHC) class I and class II and the membrane attack complex (MAC) were analysed. " 03/01/2003 - "Membrane attack complex formation in deficient membrane bound CD59 may also exacerbate synovial cell injury and inflammation." 04/01/2001 - "These findings indicate that complement activation and membrane assembly of sublytic C5b-9 play an important role in inflammation by promoting cell proliferation and by rescuing apoptotic cells."
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 07/01/1998 - "This study investigated whether increased plasma levels of terminal complement complex (SC5b-9) or split products correlate with disease activity and clinical manifestations in Brazilian systemic lupus erythematosus (SLE) patients. " 11/04/2011 - "These results raise the possibility that ICs and the nonlytic C5b-9 modulate T cell-mediated responses in systemic lupus erythematosus and other related chronic inflammatory disorders." 11/01/1987 - "Terminal complement complex in plasma from patients with systemic lupus erythematosus and other glomerular diseases." 02/04/1982 - "Cutaneous localization of the membrane attack complex in discoid and systemic lupus erythematosus." 07/01/1982 - "Immunopathology of the membrane attack complex in systemic lupus erythematosus nephritis."
3.	Infection 04/01/2014 - "The differential kinetics between cell-free killing and phagocytosis of invasive nontyphoidal Salmonella allows these bacteria to escape the blood and establish intracellular infection before they are killed by the membrane attack complex. " 02/01/2005 - "A Plasmodium sporozoite protein with a membrane attack complex domain is required for breaching the liver sinusoidal cell layer prior to hepatocyte infection." 04/01/1999 - "No clear-cut relationship between the terminal complement complex and outcome was found, even if it was significant in the models for renal and central nervous system dysfunction and infections (P =.006). " 09/01/2015 - "Further bioinformatic analysis indicated that SeV infection inhibits cell cycle-related proteins and membrane attack complex-related proteins, all of which are beneficial for the survival and replication of SeV within host cells. " 09/01/2015 - "Blockage of the biological function of RCA members, particularly CD59 (a key RCA member that controls formation of the membrane attack complex at the terminal stage of the complement activation cascades via all three activation pathways), has rendered both HIV-1 virions and infected cells sensitive to ADCML mediated by anti-Env antibodies (Abs) or sera/plasma from patients at different stages of viral infection. "
4.	Membranous Glomerulonephritis (Membranous Nephropathy) 06/01/2010 - "To study its antiproteinuric properties, we established an experimental rat model of passive Heymann nephritis and a C5b-9 injury model of podocytes in vitro. " 09/01/2011 - "Podocytes injury mediated by complement complex C5b-9 is the main feature of membranous nephropathy (MN). " 12/01/2010 - "Different from primary membranous nephropathy, hepatitis B virus associated membranous nephropathy (HBV-MN) shows lower deposits of membrane attack complex (C5b-9) in glomerular subepithelium. " 07/01/2003 - "Clinical correlates of serial urinary membrane attack complex estimates in patients with idiopathic membranous nephropathy." 01/01/2002 - "Cellular immune responses and C5b-9 seem to play an important role in the pathogenesis and progression of idiopathic membranous nephropathy (IMN). "
5.	Proteinuria 11/01/1999 - "These studies document for the first time an important role for C6, and therefore C5b-9, in the pathogenesis of nonimmunologic tubulointerstitial injury induced by proteinuria. " 01/01/2011 - "Complement activation leads to assembly of C5b-9 on podocyte plasma membranes, and results in sublethal podocyte injury and proteinuria. " 10/01/2005 - "Complement activation leads to assembly of C5b-9 on glomerular epithelial cell (GEC) plasma membranes and is essential for sublethal GEC injury and the onset of proteinuria. " 05/01/2005 - "Targeted inhibition of complement activation by Crry, and of membrane attack complex (MAC) formation by CD59 was equally therapeutic, demonstrating that the MAC plays a key role in proteinuria-induced tubulointerstitial injury. " 02/01/2005 - "Here, we examined whether C5b-9 has a pathogenic role in tubulointerstitial disease in the absence of proteinuria. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Complement System Proteins (Complement)
3.	Antigen-Antibody Complex (Immune Complex)
4.	Complement Membrane Attack Complex (Membrane Attack Complex)
5.	Vitronectin
6.	Monoclonal Antibodies
7.	Antigens
8.	Immunoglobulin G (IgG)
9.	CD59 Antigens
10.	Anaphylatoxins

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplants (Transplant)
4.	Lasers (Laser)
5.	Ligation