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Complement C5a (Complement 5a)

The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Also Known As:
Complement 5a; C5a Complement; Complement Component 5a; C5a, Complement; Complement, C5a; Component 5a, Complement
Networked: 190 relevant articles (5 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Woodruff, Trent M: 11 articles (01/2022 - 07/2011)
2. Lambris, John D: 5 articles (01/2022 - 12/2003)
3. Vater, Axel: 5 articles (01/2022 - 04/2013)
4. Taylor, Stephen M: 5 articles (10/2019 - 01/2004)
5. Li, Gui-Qing: 4 articles (01/2020 - 12/2017)
6. Tang, Ming: 4 articles (01/2020 - 12/2017)
7. Xu, Gui-Lian: 4 articles (01/2020 - 12/2017)
8. Ward, Peter A: 4 articles (10/2018 - 01/2009)
9. Okada, Hidechika: 4 articles (03/2016 - 06/2003)
10. Okada, Noriko: 4 articles (03/2016 - 06/2003)

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Related Drugs and Biologics

1. avacopan
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6. Complement System Proteins (Complement)
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8. Proteins (Proteins, Gene)
9. Anaphylatoxins
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