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Estrogen Replacement Therapy

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The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.

Also Known As:

Estrogen Progestin Combination Therapy; Estrogen Progestin Replacement Therapy; Estrogen Replacement; Replacement, Estrogen; Therapy, Estrogen Replacement; Estrogen Replacement Therapies; Estrogen Replacements; Hormone Replacement Therapy, Post Menopausal; Replacement Therapies, Estrogen; Replacements, Estrogen; Therapies, Estrogen Replacement; Hormone Replacement Therapy, Post-Menopausal; Postmenopausal Hormone Replacement Therapy; Replacement Therapy, Estrogen

Networked: 1719 relevant articles (125 outcomes, 299 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Drug Therapy: 178671
  - Hormone Replacement Therapy: 4289
    - Estrogen Replacement Therapy: 1719

Experts

1.	Herrington, David M: 15 articles (12/2010 - 03/2002)
2.	Shuid, Ahmad Nazrun: 8 articles (01/2015 - 01/2011)
3.	Mohamed, Norazlina: 6 articles (12/2013 - 01/2011)
4.	Hodis, Howard N: 6 articles (06/2013 - 01/2003)
5.	Mack, Wendy J: 5 articles (06/2013 - 01/2003)
6.	Reboussin, David M: 5 articles (07/2009 - 03/2002)
7.	Herrington, D M: 5 articles (08/2007 - 06/2000)
8.	Muhammad, Norliza: 4 articles (01/2013 - 01/2011)
9.	Sohrabji, Farida: 4 articles (09/2010 - 06/2005)
10.	Miller, V M: 4 articles (09/2009 - 01/2000)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 06/01/2001 - "Estrogen replacement therapy in menopausal women has been suggested to be beneficial in preventing the progression of cognitive impairment in Alzheimer disease. " 05/01/2000 - "It has been shown that estrogen replacement in menopausal women is effective in slowing down the progression of cognitive impairment in Alzheimer's disease. " 02/23/2000 - "Several reports from small clinical trials have suggested that estrogen replacement therapy may be useful for the treatment of Alzheimer disease (AD) in women. " 01/01/1998 - "Epidemiologic studies suggest protective effects against Alzheimer's disease from postmenopausal estrogen replacement and nonsteroidal anti-inflammatory drugs. " 10/01/1998 - "Collectively, these data demonstrate the ability for estrogen replacement to attenuate specific pharmacologically induced impairments in learning and retention and provide additional clues as to potential mechanisms by which estrogen replacement may help to reduce cognitive deficits associated with aging and Alzheimer's disease in postmenopausal women."
2.	Osteoporosis 10/01/1999 - "Estrogen replacement therapy is increasingly used by perimenopausal and postmenopausal women for management of menopausal symptoms and for long-term protection against osteoporosis and arterial disease. " 10/01/2000 - "Observational studies do not suggest any superiority of a given progestogen regarding cardiovascular risk, prevention of osteoporosis, and cognitive function in postmenopausal women on estrogen replacement therapy. " 03/01/1990 - "Although clinicians and policy groups have advocated estrogen replacement therapy and other clinical measures to prevent osteoporosis, few studies have assessed whether these measures are being adopted by physicians in practice. " 01/17/2011 - "The osteoporosis that developed 5 months after ovariectomy was significantly ameliorated by estrogen replacement therapy. " 01/01/2007 - "[Use of estrogen-replacement therapy in menopause--secondary prevention of osteoporosis]."
3.	Postmenopausal Osteoporosis 06/01/1997 - "Replacement estrogen therapy is of proven efficacy for the prevention and treatment of postmenopausal bone loss. " 06/01/1991 - "Estrogen replacement therapy is effective in the prophylaxis of postmenopausal osteoporosis, and is the only therapy with well-proven antifracture efficacy. " 01/01/2001 - "Although estrogen replacement therapy (ERT) has been established as an effective treatment for postmenopausal bone loss, the clinical features which predict the effects of ERT have not been well investigated in Japanese postmenopausal women. " 02/01/1995 - "Estrogen replacement therapy is effective in the prevention of postmenopausal osteoporosis, and a direct action of 17-beta-estradiol (17 beta E2) on osteoblastic and osteoclastic cells has been demonstrated. " 04/01/1996 - "Estrogen replacement is known to manifest bone protective effects in the treatment of postmenopausal osteoporosis. "
4.	Cardiovascular Diseases (Cardiovascular Disease) 05/01/1996 - "These findings may help to explain the beneficial effects of estrogen replacement therapy in terms of protection from cardiovascular disease." 10/01/1999 - "Is physical activity as effective in reducing risk of cardiovascular disease as estrogen replacement therapy in postmenopausal women?" 06/01/1998 - "The aim of the present study was to evaluate the efficacy of transdermal estrogen replacement therapy in improving the risk profile of cardiovascular disease in postmenopausal women. " 03/01/2012 - "Although recent clinical trials have found an increased incidence of cardiovascular disease in women on estrogen replacement therapy, the underlying mechanism remains unclear. " 10/01/2006 - "Clinical trials failed to show a beneficial effect of postmenopausal hormone replacement therapy, whereas experimental studies in young animals reported a protective function of estrogen replacement in cardiovascular disease. "
5.	Coronary Artery Disease (Coronary Atherosclerosis) 05/01/2003 - "Improvement in endothelial function may be an important mechanism by which estrogen replacement therapy protects postmenopausal women against coronary artery disease. " 04/07/1998 - "Improvement in endothelial function may be an important mechanism by which estrogen replacement therapy protects postmenopausal women against coronary artery disease. " 04/01/2000 - "However, it is unknown whether long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease. " 04/01/2000 - "Long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease." 11/01/2003 - "This study was undertaken to investigate the effect of transdermal and oral estrogen replacement therapy in healthy postmenopausal women on markers of coagulation and fibrinolysis associated with coronary artery disease. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Progesterone
3.	Estradiol (Estrace)
4.	Glucose (Dextrose)
5.	Medroxyprogesterone Acetate (Depo-Provera)
6.	Progestins (Progestagens)
7.	Lipids
8.	Lipoproteins (Lipoprotein)
9.	Hormones
10.	Calcitonin (Calcitonin, Eel)

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Aftercare (After-Treatment)
3.	Ovariectomy (Oophorectomy)
4.	Hysterectomy
5.	Contraception (Birth Control)