Chelation Therapy (Therapy, Chelation)

Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.

Also Known As:

Networked: 1492 relevant articles (159 outcomes, 165 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	De Sanctis, Vincenzo: 26 articles (01/2022 - 12/2004)
2.	Porter, John B: 24 articles (01/2020 - 07/2004)
3.	Taher, Ali T: 22 articles (11/2021 - 01/2009)
4.	Lamas, Gervasio A: 18 articles (01/2022 - 03/2013)
5.	Cappellini, Maria Domenica: 16 articles (11/2021 - 05/2007)
6.	Leitch, Heather A: 13 articles (09/2019 - 12/2007)
7.	Kattamis, Antonis: 12 articles (01/2022 - 04/2010)
8.	Soliman, Ashraf T: 12 articles (01/2022 - 10/2008)
9.	Karimi, Mehran: 11 articles (01/2022 - 01/2002)
10.	Musallam, Khaled M: 11 articles (11/2021 - 01/2009)

Related Diseases

1.	Iron Overload 01/01/2009 - "The cumulative effects of iron overload cause significant morbidity and mortality if not effectively treated with chelation therapy. " 12/01/2001 - "The decrease in iron overload observed in patients on close follow up implies that compliance with chelation therapy has improved with time and therefore, a favourable influence in survival could be expected." 01/01/1999 - "The procedure is safe and effective in reducing iron overload and can obviate the need for chelation therapy, even when the target Hb S is maintained at the standard 30% range." 04/01/1995 - "The ability to quantitate transfusional iron overload is crucial for determining the need for and the efficacy of chelation therapy in patients with long-standing transfusion-dependent anaemias. " 01/01/1985 - "Chronic transfusion has become practicable since the recent advances in chelation therapy have essentially eliminated the risk of secondary iron overload."
2.	beta-Thalassemia (Cooley's Anemia) 02/01/2005 - "Hypertransfusion and regular chelation therapy have allowed improved survival in patients with thalassemia major (TM). " 01/01/2022 - "This study aims to analyze the posterior segment of the eye in children with thalassemia major (TM) treated with chelation therapy. " 11/01/2013 - "Our study included 33 patients diagnosed with beta-thalassemia major who were treated with regular transfusions and chelation therapy. " 10/01/2004 - "All available radiographs and MRI studies of the knees in 14 beta-thalassemia major patients (mean age, 16.3 years; age range, 7-33 years) undergoing chelation therapy with L1 were retrospectively assessed for changes in the synovium, cartilage, and bone. " 01/01/1991 - "This study examined anterior pituitary function and the effect of chelation therapy in 31 patients with beta-thalassemia/HbE disease. "
3.	Thalassemia 10/01/2022 - "Repeated blood transfusions along with chelation therapy are mainstay of treatment in thalassemia patients. " 09/01/2022 - "Background With optimum transfusion and chelation therapy, the survival of β-thalassemia patients and the incidence of various complications, including renal complications, have improved. " 01/01/2008 - "Effects of chelation therapy on cardiac function improvement in thalassemia patients: literature review and the Taiwanese experience." 01/01/2022 - "A search was conducted in the electronic databases like Medline, PubMed, etc. for screening studies reporting various aspects including gene therapy, prevention strategies, blood, transfusion and chelation therapy for the management of β-thalassemia. " 08/01/2018 - "The aim of the study was to assess the relationship of cardiac and hepatic T2* values with chelation therapy in patients with transfusion-dependent thalassemia (TDT). "
4.	Lead Poisoning (Poisoning, Lead) 03/01/1997 - "In summary, LXRF estimates of Pb in tibial cortical bone have yielded highly relevant clinical data relating to the efficacy of chelation therapy with CaNa2EDTA in lead poisoned children; diagnostic approach(es) to childhood lead poisoning; and evaluations of exposure in children, teenagers, and adults in lead-exposed and non-lead-exposed suburban communities. " 01/01/1988 - "Two children with lead poisoning had delayed conduction in the peripheral pathways only and in these there was good correlation between the degree of delay and the ulnar nerve conduction velocity; both improved after chelation therapy. " 09/01/1991 - "Although both patients improved with several months of intramuscular chelation therapy, the efficacy of such therapy in chronic lead poisoning is controversial. " 11/30/2022 - "Chelation therapy is usually used to manage lead poisoning. " 01/01/2022 - "Consent was obtained from 42 individuals diagnosed with lead poisoning and blood and urine samples were collected before and after chelation therapy. "
5.	Poisoning 03/01/1984 - "Therefore, it appears that MT does not play an important role in the acute decrease in efficacy of chelation therapy for Cd poisoning. " 05/01/1983 - "Therefore, if appears that MT does not have an important role in the acute decrease in efficacy of chelation therapy for Cd poisoning. " 02/01/1996 - "Even though there is no doubt that chelation therapy has significantly contributed to reduce mortality and morbidity from occupational Pb poisoning, the efficacy of this treatment in subjects with subtle neurological or renal damage has not yet been studied properly." 03/01/2020 - "The current study aimed at establishing the extent of Pb poisoning and exposure differences among family members in Kabwe as well as determining populations at risk and identify children eligible for chelation therapy. " 02/01/2019 - "Chelation therapy was used to reduce the adverse effects of acute and chronic poisoning by metals. "

Related Drugs and Biologics

1.	Iron
2.	Deferoxamine (Desferal)
3.	Edetic Acid (EDTA)
4.	Deferasirox
5.	Deferiprone
6.	Ferritins (Ferritin)
7.	Chelating Agents
8.	Penicillamine (Cuprimine)
9.	Metals
10.	Cadmium

Related Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions)
2.	Therapeutics
3.	Transplantation
4.	Erythrocyte Transfusion
5.	Splenectomy