Mydriasis

Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.

Networked: 891 relevant articles (44 outcomes, 55 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cataract (Cataracts)
2.	Uveitis
3.	Inflammation
4.	Miosis
5.	Pain (Aches)

Experts

1.	Behndig, Anders: 8 articles (08/2014 - 12/2003)
2.	Yu, Yongxin: 6 articles (01/2005 - 02/2002)
3.	Koss, Michael C: 6 articles (01/2005 - 02/2002)
4.	Lundberg, Björn: 4 articles (08/2012 - 12/2003)
5.	Briganti, Angela: 3 articles (03/2012 - 09/2010)
6.	Ceccherelli, Renato: 3 articles (03/2012 - 09/2010)
7.	Barsotti, Giovanni: 3 articles (03/2012 - 09/2010)
8.	Breghi, Gloria: 3 articles (03/2012 - 09/2010)
9.	Leino, Tiina: 3 articles (12/2009 - 11/2003)
10.	Haapalinna, Antti: 3 articles (12/2009 - 11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mydriasis:

1.	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/01/2007 - "The current study found that mydriasis from phenylephrine, with minimal effect on accommodation, did not result in significant corneal alteration, and corneal topography can be measured after pupil dilation with phenylephrine." 01/01/2007 - "The current study investigates the effect of mydriasis on corneal shape using phenylephrine alone, where phenylephrine has minimal effect on the accommodative system and whether corneal topography can be done after pupil dilation. " 01/01/2015 - "Clinical data examined included age, sex, duration of clinical signs, ancillary diagnostic test results, and time to mydriasis on topical ocular application of 1% phenylephrine. " 01/01/2013 - "We wish to highlight the importance of acknowledging the accompanying effects of topical phenylephrine drops on the eye other than its intended mydriasis. " 04/01/2010 - "2.5% and 10% phenylephrine for mydriasis in diabetic patients with darkly pigmented irides."
2.	Ophthalmic Solutions (Eye Drops)IBA 12/01/2004 - "The size of the maximal mydriasis obtained when using the insert was significantly greater than that obtained when using the eye drops, regardless of the frequency of the instillation (p < 0.04). " 01/01/2013 - "In the first study, MY achieved superior mydriasis compared to PT eye drops at 90min (9.04±1.33mm vs 8.78±1.37mm, P=0.012). " 07/01/2011 - "Intraoperative mydriasis by intracameral injection of mydriatic eye drops: in vivo efficacy and in vitro safety studies." 09/01/2006 - "The primary objective of this study was to compare eye drops and inserts in terms of the quality of preoperative mydriasis. " 10/01/2004 - "The ability of Mydriasert to provide mydriasis (defined by a pupillary diameter of at least 7 mm) compatible with a bilateral angiographic examination in optimal conditions was evaluated by a comparative, randomised versus active treatment (eye drops) open trial in 72 patients. "
3.	TropicamideFDA LinkGeneric 12/01/2012 - "The aim of this study was to evaluate by serial measurements, pupil mydriasis produced by topical application of tropicamide 1% using a spray in a closed eye or instillation in an open eye in adult and elderly populations. " 03/01/2012 - "This study investigated the association of transient changes in intraocular pressure (IOP) with changes in the anterior chamber configuration in children after diagnostic mydriasis with 1% tropicamide. " 08/01/1995 - "The aim of this study was to investigate the effect of nasolacrimal occlusion on tropicamide-induced mydriasis. " 03/01/2015 - "Effect of mydriasis induced by topical 0.5% tropicamide instillation on the corneal biomechanical properties in healthy individuals measured by ocular response analyzer." 01/01/2015 - "Tropicamide is an antimuscarinic ophthalmic solution used to produce short-acting mydriasis and cycloplegia. "
4.	Epinephrine (Adrenaline)FDA LinkGeneric 02/01/1994 - "The mydriasis maintained during irrigation aspiration was significantly greater in the group receiving adrenaline (6.6 versus 6.0 mm, p < 0.02). " 06/01/2001 - "To maintain intraoperative mydriasis, one bolus of epinephrine injection was used in our study. " 11/01/2014 - "In the fellow eye, intracameral bisulfate-free epinephrine alone was injected above and below the iris plane for intraoperative mydriasis and to deepen the anterior chamber, which prevented a reverse pupillary block. " 11/01/2014 - "A staged procedure was followed to achieve mydriasis and deepen the anterior chamber with bisulfate-free epinephrine (epi-Shugarcaine) and an ophthalmic viscosurgical device (OVD) prior to the femtosecond procedure. " 11/01/2008 - "Despite its effective and immediate mydriatic effect, intracameral epinephrine is not recommended for intraoperative mydriasis in procedures such as IOL repositioning or secondary IOL implantation in which minimal irrigating solution is used."
5.	Flurbiprofen (Froben)FDA LinkGeneric 09/01/1993 - "The results indicate that flurbiprofen was significantly more effective (P < .0001) in maintaining mydriasis during surgery than the placebo. " 10/01/1992 - "Thus a maintained intraoperative mydriasis in flurbiprofen group led to better E.C.L.E. " 10/01/1992 - "The maintained intraoperative mydriasis in the two groups before anterior chamber entry (stage I) vs at the end of complete cortex wash (stage III) was: in control group (stage I) 8.46 +/- 0.48 mm vs (stage III) 3.56 +/- 0.43 mm (highly SS); in flurbiprofen group (stage I) 8.60 +/- 0.48 mm vs (stage III) 8.01 +/- 0.63 mm (NSS). " 08/01/2000 - "Pre-operative diclofenac and flurbiprofen drops are effective in maintaining intraoperative mydriasis. " 10/01/2010 - "Nepafenac was more effective than a placebo and flurbiprofen in achieving maximum preoperative and postoperative pupil mydriasis in rabbits."
6.	dapiprazole (Rev-Eyes)FDA Link 02/01/1999 - "We also evaluated the efficacy of one drop of dapiprazole (Rev-Eyes) in reversing Paremyd-induced mydriasis in our subject sample. " 12/01/2000 - "There is evidence that reaching normal pupil diameters after reversal of mydriasis by dapiprazole is a valid sign of restoration of traffic related functions." 12/01/2000 - "Before mydriasis and after reversal with dapiprazole traffic-related functions were evaluated (photopic visual acuity, mesopic vision, sensitivity to glare, colour vision, accommodation, visual field). " 08/01/1997 - "Dapiprazole HCL is currently available in the United States for reversal of diagnostic mydriasis. " 11/01/1991 - "The results showed a significant reversal of mydriasis by intraocular dapiprazole, especially with the 0.25% and 0.5% concentrations which did not differ significantly in effectiveness and safety."
7.	Diclofenac (SR 38)FDA LinkGeneric 01/01/2000 - "To establish the role of preoperative subconjunctival mydricaine and diclofenac 0.1% in maintaining mydriasis during vitrectomy. " 01/01/2000 - "The role of preoperative subconjunctival mydricaine and topical diclofenac sodium 0.1% in maintaining mydriasis during vitrectomy." 05/01/1998 - "To determine whether systemic diclofenac sodium affects the maintenance of mydriasis during phacoemulsification and to compare pupil diameter regression rates with those in a control group. " 05/01/1998 - "Systemic diclofenac sodium to maintain mydriasis during phacoemulsification." 01/01/1997 - "The maintenance of per-operative mydriasis in phacoemulsification with topical diclofenac sodium."
8.	Cyclopentolate (Cyclogyl)FDA LinkGeneric 06/01/2013 - "Patients were measured at autorefractometer without mydriasis, and then after using UNITROPIC 1% or CYCLOGYL 1%. " 11/01/2011 - "The Cyclopentolate 1.0% can achieve the peak time of refraction 10 minutes early as well as increase the effect of mydriasis when it is used combined with topical anaesthetic. " 01/01/2010 - "Cyclopentolate is used to induce quick and successful mydriasis for pediatric eye examination. " 01/01/2006 - "Aberrometry was performed with a wavefront analyzer (after cycloplegia and mydriasis with cyclopentolate 1%). " 09/01/2002 - "Changes in intraocular pressure following diagnostic mydriasis with cyclopentolate 1%."
9.	Atropine (Hyoscyamine)FDA LinkGeneric 10/01/2015 - "Atropine is an anticholinergic drug for mydriasis in eye clinic, and its abuse might be cytotoxic to the cornea and result in blurred vision. " 05/01/2015 - "The effects of the microparticle formulation on mydriasis in comparison with the marketed atropine sulfate solution were evaluated in rabbit eyes. " 04/01/2012 - "Atropine treatment showed a rapid widening of the pinpoint pupils exceeding baseline level finally causing mydriasis. " 01/01/2012 - "Left pupil mydriasis was induced with topical atropine. " 12/01/2003 - "Duration of mydriasis after administration of 1% atropine sulfate ophthalmic solution in the normal equine eye is greater than 14 days. "
10.	nepafenac (Nevanac)FDA Link 10/01/2010 - "Nepafenac-assisted mydriasis in a rabbit model." 01/01/2009 - "Prophylactic use of nepafenac was effective in reducing macular edema after cataract surgery and in maintaining trans-operative mydriasis." 01/01/2009 - "To evaluate the effectiveness of prophylactic administration of nepafenac 0.1% in maintaining mydriasis and in preventing postoperative macular edema following cataract surgery. " 10/01/2010 - "Nepafenac was more effective than a placebo and flurbiprofen in achieving maximum preoperative and postoperative pupil mydriasis in rabbits." 09/01/2015 - "This study compared the effectiveness of prophylactic administration of topical flurbiprofen 0.03% and nepafenac 0.1% in maintaining mydriasis during small incision cataract surgery (SICS). "

Therapies and Procedures

1.	Phacoemulsification 08/01/1998 - "The mydriasis maintained during phacoemulsification was significantly greater in the study group, p < 0.00001. " 12/01/2014 - "Effect of topical nonsteroidal anti-inflammatory drugs and nuclear hardness on maintenance of mydriasis during phacoemulsification surgery." 03/01/2014 - "Intracameral mydriatic solution can eliminate the disadvantages of repeated eye drop instillation regimen and provide adequate mydriasis for phacoemulsification with added advantages. " 11/01/2013 - "Phacoemulsification in eyes with a narrow pupil, unresponsive to preoperative pharmacologic mydriasis, is challenging. In the presented case of iridoschisis with anterior and posterior synechiae, 2 ophthalmic viscosurgical devices were used and balanced salt solution was used as the infusion fluid. " 04/01/2012 - "In cases of phacoemulsification surgery with inadequate mydriasis implantation of a Malyugin ring is a simple, safe and fast alternative to iris-retractors; it allows better pupil-size without additional stab incisions."
2.	Topical Administration 09/01/2010 - "Results of the present study suggest that a single topical administration of 0.35 mg of rocuronium bromide to the eyes of healthy tawny owls results in sufficient mydriasis to allow for a complete examination of the fundus." 09/01/2010 - "A single concurrent topical administration of rocuronium bromide to the eyes of the examined birds induced a complete bilateral mydriasis in both eyes without causing any adverse effect." 09/01/2010 - "Bilateral mydriasis in common buzzards (Buteo buteo) and little owls (Athene noctua) induced by concurrent topical administration of rocuronium bromide." 06/18/1999 - "After topical administration on the guinea-pig eye conjunctiva, desloratadine produced a potent (ED50 = 2.3 mg/ml) and long lasting mydriasis (> 120 min at the ED50) in conscious animals. " 10/01/2008 - "Topical administration of diclofenac was effective in maintaining mydriasis during vitrectomy and in reducing postoperative pain and anterior chamber flare as determined by slit-lamp evaluations."
3.	Intraocular Lenses (Intraocular Lens) 09/01/2012 - "To evaluate the efficacy and safety of using coreoplasty, and an iris-supported Artisan intraocular lens (IOL), for mydriasis and aphakic correction in post-traumatic vitrectomized eyes. " 01/01/2006 - "[Mydriasis--areflexia syndrome in eye with posterior chamber intraocular lens]." 07/01/1991 - "The principal causes impeding the examination of the retina were (1) posterior capsule opacity, (2) inadequate mydriasis because of synechias between the iris and the intraocular lens. " 01/01/1985 - "The surgeon, especially the neophyte, must recognise which irises may present a difficulty in establishing, maintaining, and reversing mydriasis, with or without the introduction of an intraocular lens. " 01/01/1985 - "The indication for iridectomy in extracapsular lens extraction with or without an intraocular lens is reviewed, and the postoperative manipulation of the iris is described with reference to the problems caused by rebound mydriasis."
4.	Cataract Extraction 05/01/1991 - "Maintaining successful mydriasis is essential during cataract extraction. " 10/01/1975 - "In three eyes which underwent cataract extraction no evidence of senile pseudoexfoliation was found either before, or immediately after, surgery in spite of repeated biomicroscopical examination under full mydriasis. " 01/01/1965 - "[Myosis and mydriasis during cataract extraction]." 01/01/1998 - "One of the important points in extracapsular cataract extraction with posterior chamber intraocular lens implantation is to maintain mydriasis during the intervention. " 06/01/1993 - "Deficient mydriasis of diverse etiology renders extracapsular cataract extraction and posterior chamber intraocular lens implantation technically difficult. "
5.	Injections 01/01/1995 - "Persistent tachycardia following subconjunctival injections of mydriatic agents (Mydricaine) used for maintenance of perioperative mydriasis in vitreoretinal surgery." 11/01/2013 - "Sub-Tenon's lidocaine injections provide excellent akinesia and mydriasis compared to systemic AT and retrobulbar lidocaine injections. " 07/01/1990 - "These responses were due to central cholinergic stimulation; mydriasis was eliminated by ICV injection of atropine and the elevation of IOP was significantly reduced by ICV injections of atropine and hexamethonium. " 11/01/2013 - "To compare the effect of sub-Tenon's lidocaine injections (ST) on akinesia and mydriasis to those of systemic atracurium (AT) and retrobulbar lidocaine injections in dogs. " 11/01/2013 - "Comparison of systemic atracurium, retrobulbar lidocaine, and sub-Tenon's lidocaine injections in akinesia and mydriasis in dogs."