Pars Planitis

Form of granulomatous uveitis occurring in the region of the pars plana. This disorder is a common condition with no detectable focal pathology. It causes fibrovascular proliferation at the inferior ora serrata.

Also Known As:

Networked: 90 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Retinal Vasculitis
2.	Macular Edema
3.	Cataract (Cataracts)
4.	Posterior Uveitis
5.	Anterior Uveitis

Experts

1.	Ozdal, Pinar Cakar: 3 articles (02/2022 - 10/2015)
2.	Ozdemir, Huseyin Baran: 2 articles (02/2022 - 01/2022)
3.	Pedroza-Seres, Miguel: 2 articles (06/2017 - 11/2014)
4.	Serna-Ojeda, Juan Carlos: 2 articles (06/2017 - 11/2014)
5.	Batur, Muhammed: 1 article (07/2022)
6.	Ozer, Muhammet Derda: 1 article (07/2022)
7.	Niederer, Rachael L: 1 article (01/2022)
8.	Pepin, Francois: 1 article (01/2022)
9.	Amer, Radgonde: 1 article (08/2020)
10.	Koriat, Adi: 1 article (08/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pars Planitis:

1.	SteroidsIBA 07/01/1994 - "Transconjunctival cryopexy of the vitreous base is clinically effective in patients with steroid nonresponsive pars planitis who have peripheral neovascularization. " 11/01/2014 - "Immunosuppressive therapy allows an adequate control of inflammatory disease in pars planitis, with clinical and visual improvement and steroid dose reduction." 04/13/2015 - "Our patient, a 47-year-old woman, developed intermediate uveitis after cataract surgery in her right eye, was misdiagnosed as pars planitis, and received steroid monotherapy for 8 months. " 04/01/1995 - "A significant flare reduction after start of steroid therapy was seen in Behçet uveitis (78% reduction), sarcoidosis (44.8%), and pars planitis (51%), but not in toxoplasmosis or in birdshot. " 06/01/2020 - "Pediatric ophthalmologists were more likely to respond that the presence of chronic juvenile idiopathic arthritis-associated iridocyclitis, pars planitis, or recurrent acute anterior uveitis is a contraindication for primary IOL implantation in pediatric cases with full control of intraocular inflammation. There was no consensus within either specialty with regard to the preferred IOL material for lens implantation. Uveitis ophthalmologists were more likely to report the use of intravenous and intravitreal steroids for perioperative treatment. "
2.	Tacrolimus (Prograf)FDA LinkGeneric 04/01/1999 - "The patient with pars planitis had an improvement in VA from 6/18 to 6/9. The patient with retinal vasculitis showed partial regression of neovascularization on tacrolimus. "
3.	Fluorescein (Funduscein)FDA LinkGeneric 07/01/1994 - "The authors report the first study of patients with refractory pars planitis in which fluorescein angiography of the inferior pars plana snowbanks was performed both before and after cryopexy of the vitreous base. " 07/01/1994 - "A fluorescein angiographic study of patients with pars planitis and peripheral exudation (snowbanking) before and after cryopexy." 02/01/1983 - "We used vitreous fluorophotometry to supplement standard clinical techniques and fluorescein angiography to study 23 eyes in 12 patients with pars planitis. " 07/01/1994 - "Twelve consecutive phakic eyes with pars planitis and prominent peripheral snowbanks had fluorescein angiograms of the pars plana. " 01/01/1975 - "In four cases with clinical diagnosis of "pars planitis" fluorescein angiography was performed and macular area observed. "
4.	Retinaldehyde (Retinal)IBA 02/01/1983 - "[Vasculoproliferative retinal capillaropathy and pars planitis. " 10/01/2010 - "The results of this study suggest that pars plana vitrectomy has a beneficial effect on the course and visual function of patients with vitreo-retinal complications associated with pars planitis." 02/01/2016 - "To compare the long-term outcomes of peripheral retinal cryoablation to conventional treatment for active pars planitis. " 10/01/2010 - "[Vitrectomy surgery for the treatment of the vitreo-retinal complications of the pars planitis]." 09/10/2018 - "Progression of retinal pigmentation mimicking unilateral retinitis pigmentosa after bilateral pars planitis: a case report."
5.	HLA Antigens (Human Leukocyte Antigens)IBA 08/01/1993 - "To establish a human leukocyte antigen (HLA) association in a homogeneous population of patients with pars planitis. " 12/01/1990 - "Both of them and the paternal grandparents were HLA typed; no association between HLA antigens and pars planitis was found. " 04/01/2016 - "There is also a genetic predisposition for pars planitis by human leukocyte antigen and several other genes. " 03/01/1999 - "To describe a cohort of patients with pars planitis followed at a single tertiary care institution, determine the frequency of multiple sclerosis and/or optic neuritis in patients with this disorder, and calculate gene frequencies of human leukocyte antigen (HLA) class II alleles in these patients. " 10/01/2003 - "The purpose of this study was the investigation of human leukocyte antigen (HLA) genes in Mexicans with classical Pars Planitis (CPP). "
6.	HLA-DR2 Antigen (HLA DR2 Antigen)IBA 05/01/2001 - "Pars planitis is associated with an increased frequency of the HLA-DR2 suballele, -DR15, HLA-DR51, and HLA-DR17. " 08/01/1993 - "The strongest association of pars planitis with HLA-DR2 and the temporal development of MS in some patients with pars planitis further supports an association between pars planitis and MS." 03/01/1999 - "The HLA-DR15 allele, coding for one of the two HLA-DR2 subtypes, was associated with pars planitis (odds ratio = 2.86, 95% confidence interval = 1.42-5.78, P = 0.004). " 08/01/1998 - "There were no statistically significant HLA associations in these patients compared with controls from another study from Iowa, but the Iowa phakic patients with cystoid macular edema did differ from the Iowa patients with pars-planitis at loci HLA-B8, HLA-B51, and HLA-DR2. "
7.	HLA-B8 Antigen (HLA B8 Antigen)IBA 08/01/1993 - "The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis." 08/01/1998 - "There were no statistically significant HLA associations in these patients compared with controls from another study from Iowa, but the Iowa phakic patients with cystoid macular edema did differ from the Iowa patients with pars-planitis at loci HLA-B8, HLA-B51, and HLA-DR2. "
8.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 03/01/2003 - "To describe the clinical manifestations of classic pars planitis (CPP) in Mexican patients. " 10/01/2003 - "The purpose of this study was the investigation of human leukocyte antigen (HLA) genes in Mexicans with classical Pars Planitis (CPP). "
9.	HLA-B51 AntigenIBA 08/01/1998 - "There were no statistically significant HLA associations in these patients compared with controls from another study from Iowa, but the Iowa phakic patients with cystoid macular edema did differ from the Iowa patients with pars-planitis at loci HLA-B8, HLA-B51, and HLA-DR2. "
10.	Interleukin-6 (Interleukin 6)IBA 09/01/2004 - "Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies." 09/01/2004 - "The levels of IL-6 did not correlate with a specific clinical diagnosis, but patients with pars planitis and panuveitis had the highest levels (p = 0.58) IL-6 is elevated in the vitreous of patients with active intermediate and posterior uveitis."

Therapies and Procedures

1.	Immunomodulation 08/01/2020 - "Pars planitis-associated CME entailed higher prevalence of ocular complications, more frequent use of immunomodulatory therapy, and a lower rate of remission."
2.	Vitrectomy 10/01/2010 - "To evaluate the effect of pars plana vitrectomy in the management of patients with pars planitis. " 06/01/1999 - "The records of all patients who underwent pars plana vitrectomy for pars planitis from 1988 through 1997 were retrospectively reviewed. " 06/01/2017 - "The purpose of this study was to evaluate the characteristics and outcomes of cataract surgery with/without vitrectomy in patients with pars planitis who received immunosuppressive therapy. " 06/01/2017 - "Outcomes of cataract surgery with/without vitrectomy in patients with pars planitis and immunosuppressive therapy." 04/01/2001 - "A substantial long-term benefit is seen in patients with pars planitis treated with vitrectomy for nonclearing vitreous hemorrhage. "
3.	Lasers (Laser) 08/01/2013 - "The study included 29 patients (10 female and 19 male) diagnosed with pars planitis and were treated with selective laser. " 01/01/1998 - "Results of peripheral laser photocoagulation in pars planitis." 10/01/2012 - "Three pars planitis cases were associated with retinoschisis and underwent laser photocoagulation. " 10/01/2012 - "To describe cases of pars planitis associated with retinoschisis, in which laser photocoagulation was carried out. " 02/01/1990 - "The causes of PMF included retinal detachment surgery in four patients, idiopathic in three patients, laser treatment in three patients, pars planitis in one patient and diabetic retinopathy in one patient. "
4.	Therapeutics 09/01/2007 - "To report the demographics and clinical characteristics, therapy logarithm, and prognosis of children with pars planitis. " 01/01/1986 - "Cryo therapy as an adjunct to treatment in pars planitis." 04/01/1994 - "Evolution of aqueous flare and cells was analyzed for acute anterior uveitis, ARN, and pars planitis treated for cystoid macular edema (CME), all of which received a standardized therapy. " 01/01/1985 - "The patients who appeared to respond particularly well to CsA therapy were those with pars planitis, intermediate uveitis of the non-pars planitis type, VKH, and Behcet's disease. " 01/01/1992 - "Ciclosporin (Sandimmun) therapy: experience in the treatment of pars planitis and present therapeutic guidelines."
5.	Cryotherapy (Therapy, Cold) 10/01/1991 - "Cryotherapy has been reported to be of benefit in pars planitis. " 01/01/1991 - "We recommend cryotherapy as the primary treatment for pars planitis with a snowbank." 01/01/1991 - "Treatment of pars planitis with cryotherapy." 12/01/1974 - "[Cryotherapy and pars-planitis]." 10/01/1995 - "Peripheral scatter photocoagulation is efficacious and appears at least equal to peripheral cryotherapy in causing regression of neovascularization of the vitreous base in patients with pars planitis."