Panuveitis

Inflammation in which both the anterior and posterior segments of the uvea are involved and a specific focus is not apparent. It is often severe and extensive and a serious threat to vision. Causes include systemic diseases such as tuberculosis, sarcoidosis, and syphilis, as well as malignancies. The intermediate segment of the eye is not involved.

Networked: 512 relevant articles (49 outcomes, 48 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Posterior Uveitis
2.	Intermediate Uveitis (Chronic Cyclitis)
3.	Inflammation (Inflammations)
4.	Macular Edema
5.	Multifocal Choroiditis

Experts

1.	Thorne, Jennifer E: 20 articles (01/2021 - 12/2006)
2.	Kempen, John H: 17 articles (01/2021 - 11/2009)
3.	Nguyen, Quan Dong: 16 articles (01/2021 - 03/2005)
4.	Jabs, Douglas A: 15 articles (11/2020 - 12/2006)
5.	Holbrook, Janet T: 13 articles (12/2020 - 04/2010)
6.	Jaffe, Glenn J: 11 articles (01/2021 - 08/2005)
7.	Suhler, Eric B: 11 articles (01/2021 - 11/2009)
8.	Altaweel, Michael M: 10 articles (11/2020 - 04/2010)
9.	Foster, C Stephen: 10 articles (03/2016 - 02/2002)
10.	Agarwal, Aniruddha: 9 articles (10/2022 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Panuveitis:

1.	Adalimumab (Humira)FDA Link 01/01/2018 - "Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. " 11/17/2021 - "Purpose: To assess efficacy of adalimumab versus placebo in patients with active or inactive noninfectious intermediate, posterior, or panuveitis across different etiologies.Methods" 01/01/2018 - "To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. " 11/22/2023 - "This study evaluated real-life adalimumab impact in patients with active non-infectious intermediate, posterior, or panuveitis (NIIPPU). " 11/22/2023 - "Impact of adalimumab in patients with active non-infectious intermediate, posterior, and panuveitis in real-life clinical practice: HOPE study."
2.	Infliximab (Remicade)FDA Link 11/01/2011 - "A single infliximab infusion should be considered for the control of acute panuveitis, whereas repeated long-term infliximab infusions were proved to be more effective in reducing the number of episodes in refractory uveoretinitis with faster regression and complete remission of CME." 11/01/2002 - "Preliminary results strongly suggest that infliximab is remarkably effective in inducing short-term remission of almost all manifestations of the disease, including acute, sight threatening panuveitis. " 03/01/2011 - "To compare a single infusion of the anti-TNF antibody infliximab vs CSs for acute panuveitis attacks in Behçet's disease (BD). " 11/10/2001 - "Effect of infliximab on threatening panuveitis in Behçet's disease." 07/28/2001 - "Effect of infliximab on sight-threatening panuveitis in Behçet's disease."
3.	Dexamethasone (Maxidex)FDA LinkGeneric 02/01/1995 - "The authors investigated whether an intravitreal sustained-release dexamethasone device was effective in the treatment of severe panuveitis in a rabbit model. " 10/08/2021 - "The purpose of our study was to assess the outcome of VKH disease with bilateral panuveitis treated with dexamethasone intravitreal implant. " 01/31/2023 - "Occlusive Cytomegalovirus Panuveitis following Intravitreal Dexamethasone Implant." 01/10/2020 - "Ozurdex (dexamethasone intravitreal implant) for the treatment of intermediate, posterior, and panuveitis: a systematic review of the current evidence." 11/01/2017 - "To report a case of tarantula hair-induced panuveitis treated with sustained-release intravitreal dexamethasone implant and followed by sequential spectral domain optical coherence tomography imaging. "
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/01/2017 - "After initial improvement with topical corticosteroids, she continued to develop a panuveitis with an associated drop in vision to counting fingers. " 05/19/2021 - "Treatment with oral and topical corticosteroids resulted in improvement in the panuveitis, with a mild recurrence after the initial attempt to taper these drugs.Conclusion" 12/01/2017 - "Corticosteroid-Related Adverse Events Systematically Increase with Corticosteroid Dose in Noninfectious Intermediate, Posterior, or Panuveitis: Post Hoc Analyses from the VISUAL-1 and VISUAL-2 Trials." 07/13/2023 - "Then, the patient received oral corticosteroids, resulted in resolution of the panuveitis. " 09/01/2022 - "Donor-derived CD8+ T lymphocytes-induced panuveitis is recurrent but susceptible to regional corticosteroid treatment."
5.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2012 - "Combined phacovitrectomy with preoperative cyclosporin A in management of resistant panuveitis." 01/01/2022 - "Glucocorticosteroid (GC) therapy combined with cyclosporine A (CsA) readily improved the panuveitis. " 11/01/1998 - "To review the safety and efficacy of cyclosporine in the treatment of children with severe bilateral sight-threatening intermediate uveitis or panuveitis. " 12/01/2019 - "In January 2013, a 54-year-old pseudophakic woman was referred to the ocular inflammation clinic with a diagnosis of panuveitis, already on oral cyclosporine (100 mg/day) since 2010. " 07/01/2000 - "A 73-year-old woman with panuveitis and retinal vasculitis presented with a lump on her lip after 52 months of treatment with cyclosporin A. "
6.	SteroidsIBA 01/01/2012 - "This paper uses an interventional case-series study of ten eyes in nine patients with panuveitis, controlled by oral CSA with the least dose of topical and systemic steroids. " 01/01/2023 - "To report a case of syphilitic outer retinopathy revealed after progression to panuveitis after a course of oral steroids for suspected poison ivy. " 01/01/2023 - "SYPHILITIC OUTER RETINOPATHY: A MASQUERADING DIAGNOSIS REVEALED AFTER STEROID-INDUCED PROGRESSION TO PANUVEITIS." 11/23/2017 - "The panuveitis responded to oral and topical steroids but recurred after the steroids were stopped. " 09/01/2001 - "Bilateral panuveitis was successfully treated with topical steroid. "
7.	Prednisone (Sone)FDA LinkGeneric 06/08/2023 - "The findings were consistent with panuveitis and exudative RD in the setting of MM. He reported symptomatic improvement after plasmapheresis and oral prednisone initiation. " 12/01/2017 - "High-dose oral prednisone therapy produced improvement in her panuveitis with reduction in size of the left choroidal granuloma. " 05/01/2011 - "While on prednisone therapy, he developed panuveitis and vertigo. " 09/08/2016 - "This multinational phase 3 trial involved adults who had active noninfectious intermediate uveitis, posterior uveitis, or panuveitis despite having received prednisone treatment for 2 or more weeks. " 08/01/2022 - "Oral prednisone when used timely with penicillin therapy in special situations such as bilateral severe posterior uveitis, panuveitis, or optic neuritis may aid in a faster and smoother visual recovery. "
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/01/2001 - "Our success with this patient strongly supports the critical role of tumor necrosis factor in the immunopathogenesis of some cases of idiopathic panuveitis. " 01/01/2003 - "As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required." 12/20/2022 - "Long-term Experience with Anti-tumor Necrosis factor- α Therapy in the Treatment of Refractory, Non-infectious Intermediate, Posterior, and Panuveitis." 10/01/2021 - "Anti-tumor necrosis factor-alpha therapy for refractory uveitic optic disk neovascularization in active non-infectious posterior and panuveitis." 09/01/2018 - "Conventional immunosuppressive drugs, anti-TNF alpha and other biotherapies used in clinical practice are capable of controlling non-infectious anterior uveitis, posterior uveitis and panuveitis. "
9.	Mycophenolic Acid (Cellcept)FDA LinkGeneric 03/01/2012 - "Mycophenolate mofetil was the most preferred for intermediate (35%) and posterior/panuveitis (42%). " 12/22/2020 - "Results of our study showing better therapeutic efficacy when applied mycophenolate mofetil seems promising approach for treatment of non-infectious posterior uveitis and panuveitis. " 03/01/2010 - "Among 236 patients (397 eyes) treated with mycophenolate mofetil monotherapy, 20.3%, 11.9%, and 39.8% had anterior uveitis, intermediate uveitis, and posterior uveitis or panuveitis respectively; 14% had scleritis; 7.6% had mucous membrane pemphigoid; and 6.4% had other ocular inflammatory diseases. " 07/01/2017 - "Eighty patients at Aravind Eye Hospitals in Madurai and Coimbatore, India, with noninfectious intermediate, posterior, or panuveitis were randomized to receive oral methotrexate, 25 mg weekly, or oral mycophenolate mofetil, 1 g twice daily, and were followed up monthly for 6 months. " 12/01/2003 - "Mycophenolate mofetil is safe for long-term usage and is recommended for treatment of refractory panuveitis or posterior uveitis with uncontrolled inflammation despite high prednisolone maintenance dosage (>15 mg/day) or toxicity or lack of efficacy of other immuno-suppressive agents. "
10.	Interferon-alpha (Interferon Alfa)IBA 05/01/1998 - "To study long term effects of interferon alpha 2a (IFN alpha 2a) on panuveitis in seven patients with Behçet's disease in a prospective, open clinical trial. " 07/01/2003 - "[Familial recurrent bilateral panuveitis: efficiency of alpha interferon]." 07/01/2003 - "We report the cases of two brothers suffering from severe recurrent idiopathic panuveitis dramatically improved following alpha interferon therapy. " 07/01/2003 - "- Alpha interferon therapy seems efficient in severe idiopathic panuveitis. " 07/01/2007 - "Interferon-alpha as an effective treatment for noninfectious posterior uveitis and panuveitis."

Therapies and Procedures

1.	Therapeutics 06/01/2018 - "and importance: We experienced two cases of CMV panuveitis in immunocompetent adults, both of which responded well to anti-viral therapies." 10/01/2023 - "Phase III clinical trials of systemic and local therapies in adults with non-infectious intermediate, posterior, and panuveitis were included. " 08/28/2022 - "Children with panuveitis received the therapy by the help of a pediatric rheumatologist.Conclusion" 12/01/2021 - "Combinations of BRAFi and MEKi therapies were associated with OAEs from both drugs, with a possible synergistic or additive effect for diffuse abnormalities and panuveitis. " 05/01/2020 - "Local treatment of infectious and noninfectious intermediate, posterior, and panuveitis: current concepts and emerging therapeutics."
2.	Immunomodulation 04/01/2011 - "She later developed a fulminant panuveitis that responded to immunomodulatory therapy. " 02/01/2002 - "To report our analysis of the efficacy of immunomodulatory therapy on the course of 19 patients with multifocal choroiditis and panuveitis (MCP). " 01/01/2019 - "Factors associated with increased PSS-10 score in patients with uveitis included female sex (coefficient, 4.0; 95% CI, 1.6 to 6.5; P = .002), current immunomodulatory therapy (coefficient, 2.5; 95% CI, -0.3 to 5.2; P = .08), history of depression (coefficient, 3.8; 95% CI, 0.8 to 6.8; P = .02), and having posterior or panuveitis (coefficient, 2.6; 95% CI, 0.8 to 4.4; P = .006). " 04/01/2017 - "Infectious etiology, including brucellosis in endemic countries, has to be considered in the differential diagnosis before administering immunomodulatory therapy in patients with panuveitis of unknown origin." 02/01/2002 - "Multifocal choroiditis and panuveitis: immunomodulatory therapy."
3.	Injections 01/01/1992 - "Doses of 10(4) units gamma-interferon significantly reduced the severity of detachments, but injections of 10(6) units induced panuveitis." 05/01/2020 - "To determine the time to disease recurrence with long-acting injectable fluocinolone acetonide implant (FAi) for noninfectious intermediate, posterior, and panuveitis. " 10/01/2004 - "Three patients with acute severe exacerbations of noninfectious panuveitis and vitritis were treated with IVTA injections alone or as an adjunct to systemic immunosuppressive agents. " 02/01/1981 - "His disease progressed to panuveitis and neuroretinitis and was finally cured with penicillin injections for acquired syphilis. " 01/01/2017 - "Re: Jaffe et al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: 2-year results (Ophthalmology. "
4.	Vitrectomy 12/01/2005 - "To determine whether vitrectomy is safe and effective for the management of vitreoretinal complications in Behçet's patients with persistent panuveitis. " 11/01/2019 - "To study the results and safety of diagnostic vitrectomy in patients with unknown etiology panuveitis. " 08/01/2023 - "To identify the characteristics and outcome of panuveitis of undetermined origin (PUO) after diagnostic vitrectomy. " 08/01/2023 - "Panuveitis of undetermined origin after diagnostic pars plana vitrectomy: clinical characterization and long-term outcome from a tertiary referral center." 09/01/2012 - "Diagnostic vitrectomy was performed on eyes with intermediate, posterior, or panuveitis in which an etiology could not be characterized by history, clinical examination, ancillary testing, and/or laboratory testing. "
5.	Intravitreal Injections 08/01/2009 - "Panuveitis was induced in male New Zealand rabbits (2.5-3.0 kg) by intravitreal injection of Escherichia coli LPS. " 04/01/2005 - "Retrospective review of sixteen patients (20 eyes) with chronic cystoid macular edema (CME) as a consequence of controlled intermediate uveitis, posterior uveitis, or panuveitis who received at least one intravitreal injection of TA. " 06/04/2021 - "Intraoperative Intravitreal injection of 3 mg TA is an effective and safe adjunctive therapy for preventing postoperative inflammation and complications to promote early recovery for anterior uveitis or panuveitis complicated cataract patients following phacoemulsification. " 01/01/1992 - "A toxicity study revealed that intravitreal injection of greater than 10(4) units gamma-interferon consistently produced panuveitis. " 04/01/2020 - "The experimental protocol consisted of two subcutaneous injections of BCG, followed by two intravitreal injections of the same antigen, inducing panuveitis. "