Iridocyclitis

Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of the iris, and constricted, sluggish pupil. Symptoms include radiating pain, photophobia, lacrimation, and interference with vision.

Also Known As:

Networked: 354 relevant articles (13 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Arthritis (Polyarthritis)
2.	Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
3.	Keratitis
4.	Uveitis
5.	Ankylosing Spondylitis

Experts

1.	Martini, Alberto: 3 articles (05/2014 - 03/2005)
2.	Leccisotti, Antonio: 3 articles (06/2006 - 02/2005)
3.	Takeuchi, Masaru: 2 articles (01/2015 - 11/2005)
4.	Tugal-Tutkun, Ilknur: 2 articles (01/2015 - 02/2014)
5.	Weber, Jeffrey S: 2 articles (07/2012 - 01/2012)
6.	Li, Sing Your: 2 articles (03/2012 - 12/2010)
7.	Pistorio, Angela: 2 articles (09/2011 - 03/2005)
8.	Magni-Manzoni, Silvia: 2 articles (09/2011 - 03/2005)
9.	Ravelli, Angelo: 2 articles (09/2011 - 03/2005)
10.	Mahendradas, Padmamalini: 2 articles (11/2010 - 02/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Iridocyclitis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/1982 - "We treated the iridocyclitis with cycloplegia and topical corticosteroids, which relieved their symptoms and diminished the clinical signs. " 03/01/2015 - "We report the case of a 30-year-old male who was initially diagnosed with acute iridocyclitis in a different clinic and treated with topical and systemic corticosteroids. " 08/01/2011 - "Clinicians should be careful in the differential diagnosis of iris depigmentation from iridocyclitis to avoid the unnecessary use of high-dose topical corticosteroids." 10/01/1995 - "Corticosteroids remain as important drugs when life-threatening complications or blinding iridocyclitis develop. " 12/01/1982 - "Iridocyclitis was also present in two of these patients, who had not responded to treatment with systemic corticosteroids. "
2.	Antinuclear AntibodiesIBA 02/01/2014 - "Patients with early-onset antinuclear antibody (ANA)-positive oligoarticular JIA have the highest risk of developing chronic iridocyclitis. " 12/01/1994 - "Oligoarticular forms involve 4 or fewer joints and are often complicated with iridocyclitis especially in case of positive antinuclear antibodies in the serum. " 01/01/1994 - "No patient with the early onset pauciarticular disease subset, which is associated with iridocyclitis and antinuclear antibody (ANA) positivity was seen. " 04/01/1993 - "In patients without antinuclear antibodies and chronic iridocyclitis, there was an increase of DRB1*0101/02 and DQA1*0101. " 02/01/1993 - "Previous work showed an association of antinuclear antibodies (ANA) with early-onset pauciarticular disease and iridocyclitis. "
3.	Ivermectin (Mectizan)FDA Link 01/01/2014 - "Early-stage iridocyclitis diminished from 42%(rE) and 40%(lE) to 13% (rE+lE)(p<0.0001), but advanced iridocyclitis augmented (p<0.001) at 23 years PIT compared to before ivermectin. " 01/01/1990 - "There was significant regression of early lesions of the anterior segment of the eye, particularly iridocyclitis, after ivermectin treatment. " 04/01/1998 - "The data available on the impact of repeated doses of Mectizan on ocular onchocercal disease indicate a significant reduction of ocular microfilarial loads and regression of early lesions of the anterior segment, including iridocyclitis and sclerosing keratitis. " 01/01/2012 - "The other community-based study of mass biannual treatment of ivermectin in communities affected by the forest strain of O.volvulus demonstrated reductions in microfilarial load, punctate keratitis and iridocyclitis but not sclerosing keratitis, chorioretinitis, optic atrophy or visual impairment. "
4.	Retinaldehyde (Retinal)IBA 09/01/2014 - "Ophthalmologists should be alert to the changes in OCT of the macula in patients after iridocyclitis and further research on the cause and possible predisposing factors for retinal herniation is warranted." 09/01/2009 - "Retinal thickening in iridocyclitis." 01/01/2005 - "The hypopyon iridocyclitis and retinal cotton-wool spots responded. " 01/01/2005 - "She had hypopyon iridocyclitis in the right eye and retinal cotton-wool spots in the left eye. " 06/01/1997 - "The authors reviewed medical records of 18 consecutive patients who showed bilateral iridocyclitis with retinal capillary leakage but no systemic manifestations during an 11-year period from January 1985 to December 1995. "
5.	Azathioprine (Imuran)FDA LinkGeneric 05/01/1969 - "Azathioprine in active chronic iridocyclitis. " 05/01/2014 - "It is an observational case report of a 69-year-old diabetic gentleman on azathioprine for Crohn's disease who presented with recurrent episodes of hypertensive iridocyclitis. " 03/01/2012 - "She improved with high-dose corticosteroids and oral azathioprine and was subsequently found to have asymptomatic bilateral iridocyclitis. " 09/01/2006 - "Cyclosporine was added in 5 patients (45.4%) with posterior uveitis, and azathioprine in 2 of them for iridocyclitis. "
6.	FibrinIBA 01/01/1982 - "The uveitis, mostly iridocyclitis, was accompanied often by protein-rich fluid in the anterior chamber and less often by fibrin and cells in the vitreous body. " 07/01/1996 - "Nine episodes of acute anterior uveitis of varying severity ranging from mild iridocyclitis to anterior uveitis with fibrin or hypopyon, mimicking endogenous metastatic endophthalmitis, occurred in seven patients. " 09/01/2006 - "To assess the efficacy of a single intraoperative intraocular injection of triamcinolone acetonide during cataract surgery to prevent postoperative fibrin formation in patients with iridocyclitis associated with juvenile idiopathic arthritis. " 09/01/2006 - "Intraoperative intraocular injection of 4 mg of triamcinolone acetonide may be more effective than intraoperative intravenous methylprednisolone and additional postoperative short-term oral prednisolone in preventing postoperative fibrin formation after cataract surgery in patients with juvenile idiopathic arthritis and iridocyclitis."
7.	Mechlorethamine (Nitrogen Mustard)FDA Link 12/01/1953 - "[Efficacy of nitrogen mustard on iridocyclitis in Hodgkin's disease]." 01/01/1957 - "[Apparent cure of iridocyclitis of Hodgkin's disease obtained with nitrogen mustard & maintained for 3 1/2 years]."
8.	Bromocriptine (Parlodel)FDA LinkGeneric 10/15/1985 - "Endogenous iridocyclitis relieved during treatment with bromocriptine." 10/01/1989 - "The prolactin antagonist bromocriptine (2 x 2.5 mg/day) was administered prophylactically to prevent recurrence in seven patients with chronic iritis/iridocyclitis or panuveitis (Group A). "
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/01/1988 - "In all patients, the activity of the iridocyclitis improved with the addition of NSAIDs to their treatment regimens, permitting reduction in the dose of corticosteroid drugs. " 01/01/2011 - "Treatment of combined iridocyclitis and glaucoma involves steroidal and nonsteroidal antiinflammatory agents and antiglaucoma drugs. " 12/01/1988 - "The adjunctive use of nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of chronic iridocyclitis was evaluated in 14 patients, eight with juvenile rheumatoid arthritis and six with idiopathic iridocyclitis. "
10.	Acute-Phase Proteins (Acute-Phase Protein)IBA 09/01/2011 - "Predictors included sex, age at disease onset, JIA category, age and disease duration, ANA status, iridocyclitis, general anaesthesia, number and type of injected joints, acute-phase reactants and concomitant MTX therapy. " 01/01/2013 - "The randomization allocation was 1:1. Remission was defined as Bath Ankylosing Spondylitis Disease Activity Index < 4, no extra-axial manifestations of peripheral arthritis, dactylitis, tenosynovitis, or iridocyclitis, and normal acute-phase reactants. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/1988 - "Nonsteroidal anti-inflammatory drug therapy in chronic childhood iridocyclitis." 08/01/2013 - "Rounded average annual prize for treatment including pharmacotherapy, outpatient and inpatient care and laboratory follow-up was in chronic iridocyclitis € 990, in intermediate uveitis € 310 and sympathetic ophthalmia € 1550. " 09/01/1998 - "Moreover, combination of chemotherapy with interferon inductors cured involvement of the anterior segment of the eye--herpetic keratitis and iridocyclitis, which sometimes develop in the presence of HIV infection." 06/01/1993 - "The authors treated 60 patients with JRA-associated iridocyclitis with topical and regional corticosteroids, systemic nonsteroidal anti-inflammatory drugs, systemic steroids, and systemic immunosuppressive chemotherapy to achieve total quiescence of intraocular inflammation. "
2.	Intraocular Injections 09/01/2006 - "To assess the efficacy of a single intraoperative intraocular injection of triamcinolone acetonide during cataract surgery to prevent postoperative fibrin formation in patients with iridocyclitis associated with juvenile idiopathic arthritis. " 09/01/2006 - "Intraoperative intraocular injection of 4 mg of triamcinolone acetonide may be more effective than intraoperative intravenous methylprednisolone and additional postoperative short-term oral prednisolone in preventing postoperative fibrin formation after cataract surgery in patients with juvenile idiopathic arthritis and iridocyclitis."
3.	Plasma Exchange 02/01/1981 - "An 8-year-old girl with pauciarticular disease, antinuclear antibody, and uncontrollable iridocyclitis underwent 16 plasma exchanges with 5% albumin solution as replacement; despite removal of antinuclear antibody, her eye disease and arthritis were not helped. "
4.	Chinese Traditional Medicine (Traditional Chinese Medicine) 07/01/2013 - "Xiongdankaiming tablet (XDKMT), a well-known compound in traditional Chinese medicine, is widely used for the treatment of acute iridocyclitis and primary open-angle glaucoma. "
5.	Investigational Therapies (Experimental Therapy) 01/01/1979 - "Studies on the experimental therapy of iridocyclitis."