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Cysteine Proteinase Inhibitors

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Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.

Also Known As:

Acid Cysteine Proteinase Inhibitors; alpha-Cysteine Protease Inhibitors; Antagonists, Cysteine Proteinase; Inhibitors, Cysteine Protease; Inhibitors, Cysteine Proteinase; Inhibitors, alpha-Cysteine Protease; Protease Inhibitors, Cysteine; Protease Inhibitors, alpha-Cysteine; Proteinase Antagonists, Cysteine; Proteinase Inhibitors, Cysteine; alpha Cysteine Protease Inhibitors; Cysteine Protease Inhibitors; Cysteine Proteinase Antagonists; Cysteine Proteinase Inhibitors, Endogenous; Cysteine Proteinase Inhibitors, Exogenous

Networked: 116 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Molecular Mechanisms of Pharmacological Action: 7
    - Enzyme Inhibitors: 685
      - Protease Inhibitors: 4307
        Cysteine Proteinase Inhibitors: 116

Experts

1.	Caffrey, Conor R: 3 articles (01/2012 - 09/2006)
2.	Lah, Tamara T: 3 articles (05/2010 - 05/2002)
3.	Rosenthal, Philip J: 3 articles (01/2010 - 12/2003)
4.	Kos, J: 3 articles (05/2004 - 02/2000)
5.	Hook, Vivian: 2 articles (03/2014 - 02/2007)
6.	Gut, Jiri: 2 articles (01/2010 - 06/2004)
7.	McKerrow, James H: 2 articles (10/2008 - 11/2007)
8.	Brodt, P: 2 articles (08/2008 - 04/2001)
9.	Chevet, E: 2 articles (08/2008 - 04/2001)
10.	Navab, R: 2 articles (08/2008 - 04/2001)

Related Diseases

1.	Carcinoma (Carcinomatosis) 05/17/2004 - "The correlation between high cystatin C levels and improved survival concurs with the concept of the protective role of high levels of cysteine proteinase inhibitors in tissue homogenates that has been previously suggested by the survival results in breast and lung carcinoma as well as SCCHN." 11/01/2013 - "To preliminarily investigate the expression of cysteine proteinase inhibitors C (cystatin C) in primary hepatic carcinoma. " 01/01/1997 - "The activities and subcellular localization of cathepsin B and cysteine proteinase inhibitors in human ovarian carcinoma." 01/31/1992 - "Cysteine proteinase inhibitors (CpI) of all three families were found in ascites fluid from patients with ovarian carcinoma. " 01/02/1992 - "The differences in activity of cysteine proteinase inhibitors (CPIs) between tumor and control breast tissues was also observed: in approximately two thirds of carcinomas, lowered CPI activity was measured (group-I patients), while similar or higher tumor CPI activity was measured in the remaining samples (group-II patients). "
2.	Chagas Disease (American Trypanosomiasis) 01/01/2014 - "Reversible cysteine protease inhibitors show promise for a Chagas disease cure." 11/01/2007 - "A promising group of new drug leads for Chagas' disease is cysteine protease inhibitors targeting cruzain, the major protease of T. " 01/01/1999 - "[Trypanocidal effect of cysteine protease inhibitors in vitro and in vivo in experimental Chagas disease]." 01/31/2002 - "Targeted libraries of ketone-based cysteine protease inhibitors were synthesized and screened against cruzain, a cysteine protease implicated in Chagas' disease. "
3.	Neoplasms (Cancer) 02/01/1995 - "However, additional studies are necessary in order to prove functional roles for the individual cysteine protease inhibitors in tumor growth and progression." 08/01/2001 - "The potentiating effect of beta-(1-->3)-D-carboxymethylglucan is related to accumulation of cysteine proteinase inhibitors in the tumor tissue and plasma, but not to changes in blood cell composition." 07/01/2001 - "Therefore cysteine protease inhibitors are regarded as protective factors, able to prevent tumor growth and dissemination. " 04/19/1996 - "These results suggest that cysteine proteinase inhibitors and a tumor promoter synergistically transformed NIH3T3 cells. " 04/19/1996 - "Synergistic induction of anchorage-independent growth of NIH3T3 mouse fibroblasts by cysteine proteinase inhibitors and a tumor promoter."
4.	Infection 08/17/1998 - "This study provides proof of concept that cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a parasitic infection." 03/01/2013 - "Furthermore, a specific post infection upregulation of cysteine protease inhibitors was found in susceptible I/St mice." 10/24/2008 - "Cysteine protease inhibitors arrest infection by the protozoan parasite, Trypanosoma brucei. " 07/01/2006 - "Herein we demonstrate that the cysteine protease inhibitors aziridine-2,3-dicarboxylates 13b and 13e impaired promastigote growth at mid-micromolar concentrations and decreased the infection rate of peritoneal macrophages at concentrations 8- to 13-fold lower than those needed to inhibit parasite replication. " 08/17/1998 - "Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection."
5.	Malaria 03/01/2010 - "Computational approaches for the discovery of cysteine protease inhibitors against malaria and SARS." 01/01/2009 - "Irreversible effect of cysteine protease inhibitors on the release of malaria parasites from infected erythrocytes." 02/01/2007 - "Cumulative evidence from studies of Trypanosoma species and malaria parasites has shown that cysteine protease inhibitors represent potent anti-parasitic agents capable of curing infections in vivo. " 07/01/2008 - "Cysteine protease inhibitors kill malaria parasites and are being pursued for development as antimalarial agents. " 12/01/2003 - "We evaluated the activities of synthetic peptidyl aldehyde and alpha-ketoamide cysteine protease inhibitors against these proteases, against cultured Plasmodium falciparum parasites, and in a murine malaria model. "

Related Drugs and Biologics

1.	Cystatin C
2.	Cysteine Proteases (Cysteine Protease)
3.	E 64
4.	Protease Inhibitors (Protease Inhibitor)
5.	Praziquantel (Biltricide)
6.	Insulin-Like Growth Factor I (IGF-1)
7.	Enzymes
8.	Cathepsin D
9.	procathepsin B
10.	Cathepsin B

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Photochemotherapy (Photodynamic Therapy)
4.	Immunotherapy