Serpins

A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.

Also Known As:

Networked: 202 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lucas, Alexandra: 6 articles (08/2013 - 01/2006)
2.	Lomas, David A: 6 articles (03/2010 - 04/2003)
3.	Silverman, Gary A: 5 articles (01/2013 - 04/2002)
4.	Dai, Erbin: 5 articles (03/2010 - 03/2006)
5.	Liu, Liying: 5 articles (03/2010 - 03/2006)
6.	Viswanathan, Kasinath: 5 articles (01/2009 - 01/2006)
7.	Bottomley, Stephen P: 5 articles (03/2008 - 04/2002)
8.	McFadden, Grant: 4 articles (08/2013 - 03/2006)
9.	Huntington, J A: 4 articles (06/2013 - 01/2001)
10.	Worrall, D Margaret: 4 articles (01/2011 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2013 - "Select serpins have been associated with progression or remission of selected cancers, making them valuable for therapeutic or diagnostic use. " 09/01/2015 - "Analysis of the role of protease‑anti‑proteases (serpins) in the serum of tumor‑bearing animals in tumor growth confirmed the hypothesis that tumor growth in the body is mediated, at least in part, via balancing of serpins." 03/01/2015 - "This minireview provides an overview of serpins that are vital in regulating tumor cell migration and progressing cancer." 03/01/2015 - "The role of serpins in tumor cell migration." 05/01/2014 - "Serpins shield tumor cells from antimetastatic brain defenses."
2.	HIV Infections (HIV Infection) 01/01/2012 - "Ultimately, understanding how serpins, such as hep-ATIII, regulate host responses during HIV infection may reveal new avenues for therapeutic intervention." 01/01/2013 - "Serpins (serine protease inhibitors) are associated with protection against HIV infection. " 01/01/2014 - "This review focuses on the specific antimicrobial roles of antiproteases, focusing on serpins and cystatins, with an emphasis on their known and potential roles in HIV infection. "
3.	Thrombosis (Thrombus) 01/01/2012 - "Inhibition of coagulation cascade via FXa by ZPI and other serpins is very important safety factor for normal homeostasis protecting human life against unwanted thrombosis. " 09/01/2007 - "Factors with conformational effects on haemostatic serpins: implications in thrombosis." 07/01/2007 - "Serpins in thrombosis, hemostasis and fibrinolysis." 12/02/2003 - "The biological importance of serpins is highlighted by serpin dysfunction diseases, such as thrombosis caused by a deficiency in antithrombin. " 10/10/1991 - "Mobile reactive centre of serpins and the control of thrombosis."
4.	Infection 01/01/2014 - "Together with recently published research, this underlines the interference of EspPα with hemostasis or inflammatory responses during infection, while the observed interaction of EspI with serpins is likely to be not physiologically relevant. " 03/02/2012 - "mansoni serpins found in larval secretions, is only expressed during larval development and in the early stages of mammalian infection. " 03/01/2000 - "The serpins SCCA1 and SCCA2 are highly expressed in the epithelium of the conducting airways, a common site of infection by group C adenoviruses, such as human adenovirus type 2 (Ad2). " 06/15/1999 - "Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections." 11/07/2006 - "Serpins are central to the modulation of various innate immune responses in insects and are suspected to influence the outcome of malaria parasite infection in mosquito vectors. "
5.	Neoplasm Metastasis (Metastasis) 05/01/2014 - "Genetics: Serpins' role in brain metastasis uncovered." 11/01/2005 - "The aim of this study is to functionally characterize these tumor-associated serpins regarding the potential to influence the production of matrix metalloproteinases (MMPs), which play a key role in tumor cell invasion and metastasis. " 02/27/2014 - "By protecting cancer cells from death signals and fostering vascular co-option, anti-PA serpins provide a unifying mechanism for the initiation of brain metastasis in lung and breast cancers. " 02/27/2014 - "Serpins promote cancer cell survival and vascular co-option in brain metastasis." 11/11/2005 - "The serine protease inhibitor (serpin) superfamily is involved in a wide range of cellular processes including fibrinolysis, angiogenesis, apoptosis, inflammation, metastasis and viral pathogenesis. "

Related Drugs and Biologics

1.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
2.	Serine Proteases (Serine Protease)
3.	SERPIN-B5 (maspin)
4.	Ovalbumin
5.	Matrix Metalloproteinases
6.	A-Form DNA (A-DNA)
7.	Caspases
8.	Trypsin
9.	Peptides
10.	Angiotensinogen

Related Therapies and Procedures

1.	Therapeutics
2.	Transplants (Transplant)
3.	Liver Transplantation
4.	Lipectomy (Liposuction)
5.	Hemodilution