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Synovial Chondromatosis (Synovial Osteochondromatosis)

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Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.

Also Known As:

Synovial Osteochondromatosis; Chondromatosis, Synovial; Chondromatoses, Synovial; Chondrometaplasia, Synovial; Chondrometaplasias, Synovial; Henderson Jones Syndrome; Osteochondromatoses, Synovial; Reichel Syndrome; Reichels Syndrome; Syndrome, Henderson-Jones; Syndrome, Reichel's; Synovial Chondromatoses; Synovial Chondrometaplasias; Synovial Osteochondromatoses; Henderson-Jones Syndrome; Osteochondromatosis, Synovial; Reichel's Syndrome; Synovial Chondrometaplasia

Networked: 69 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 179
- Joint Diseases: 1919
  - Synovial Chondromatosis: 69

Related Diseases

1.	Pigmented Villonodular Synovitis
2.	Synovitis
3.	Hemangioma (Angioma)
4.	Rheumatoid Arthritis
5.	Psoriatic Arthritis

Experts

1.	Fang, Wei: 2 articles (01/2015 - 05/2014)
2.	Li, Yingjie: 2 articles (01/2015 - 05/2014)
3.	Long, Xing: 2 articles (01/2015 - 05/2014)
4.	Li, Jian: 2 articles (01/2015 - 05/2014)
5.	Meng, Qinggong: 2 articles (01/2015 - 05/2014)
6.	Cai, Hengxing: 2 articles (01/2015 - 05/2014)
7.	Deng, Mohong: 2 articles (01/2015 - 05/2014)
8.	Camins, A: 2 articles (03/2002 - 10/2000)
9.	El Mozen, Loaye Abdelaziz: 1 article (01/2015)
10.	Abraham, John A: 1 article (08/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Synovial Chondromatosis:

1.	Amyloid (Amyloid Fibrils)IBA 11/01/1997 - "MR imaging findings of some arthropathies, however--such as synovial osteochondromatosis, PVNS, and amyloid arthropath--are highly characteristic, and help in determining both diagnosis and treatment. " 03/01/2002 - "Other more unusual fluid collections and cystic lesions are described, including rice-bodies bursitis, idiopathic synovial osteochondromatosis, dialysis-related amyloid arthropathy, hemophilic arthropathy, infectious conditions, non-infectious inflammatory arthritis, and paralabral cysts." 10/01/2000 - "Such disorders include gout, Milwaukee shoulder, rapidly destructive articular disease, amyloid arthropathy, hemophilic arthropathy, primary synovial osteochondromatosis, pigmented villonodular synovitis, neuropathic arthropathy, and foreign-body synovitis. " 01/01/2006 - "Other non-rotator cuff disorders include synovial disorders such as adhesive capsulitis and synovial osteochondromatosis; degenerative disorders such as osteoarthritis, amyloid arthropathy, hemarthrosis, and chondrocalcinosis; infectious disorders such as septic arthritis and bursitis; and space-occupying lesions." 07/01/2014 - "X-ray and histological studies should be performed for its differential diagnosis with pigmented villonodular synovitis, synovial chondromatosis, synovial hemangioma, xanthoma, a group of chronic synovitis in rheumatic diseases (rheumatoid arthritis, amyloid arthropathy, psoriatic arthritis). "
2.	Interleukin-1 (Interleukin 1)IBA 05/01/1998 - "The purpose of this study was to investigate the effect of interleukin-1 on cells from loose bodies of synovial chondromatosis of the temporomandibular joint. " 05/01/1998 - "Synovial chondromatosis of the temporomandibular joint: the effect of interleukin-1 on loose-body-derived cells."
3.	Dysplasia epiphysealis hemimelicaIBA 12/01/2013 - "The mass could be differentiated from os trigonum syndrome, Trevor disease and primary synovial osteochondromatosis based on its location, size and radiologic and histological features. " 08/01/2011 - "Dysplasia epiphysealis hemimelica is a rare non-hereditary epiphyseal disease that mimics synovial chondromatosis of the joints. " 03/01/2014 - "Dysplasia epiphysealis hemimelica is a rare nonhereditary epiphyseal disease that mimics synovial chondromatosis and osteochondroma of the joints. "
4.	tebufenozide (Mimic)IBA 12/01/2009 - "Radiographs are an important component of the diagnostic armamentarium for discerning conditions that mimic synovial chondromatosis. " 01/01/1994 - "The purpose of this report is to describe giant solitary synovial chondromatosis, a previously unrecognized feature of synovial chondromatosis that may histologically and radiographically mimic a malignant neoplasm. " 05/01/2008 - "In fact, synovial chondromatosis, pigmented villonodular synovitis, synovial hemangioma, and lipoma arborescens often mimic each other as well as other, more common joint disorders in presentation, making diagnosis extremely difficult. "
5.	TenascinIBA 06/01/2004 - "We present five cases of synovial chondromatosis of the temporpmandibular joint (TMJ) which we studied by immunohistochemical methods of for transforming growth factor beta (TGFbeta) and tenascin." 08/01/1997 - "Transforming growth factor and tenascin in synovial chondromatosis of the temporomandibular joint. "
6.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 05/01/2014 - "Fibroblast growth factor 2 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint." 10/01/2002 - "The expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 in chondrocytes in synovial chondromatosis of the temporomandibular joint. "
7.	Transforming Growth Factor beta (TGF-beta)IBA 01/01/2015 - "Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint." 06/01/2004 - "We present five cases of synovial chondromatosis of the temporpmandibular joint (TMJ) which we studied by immunohistochemical methods of for transforming growth factor beta (TGFbeta) and tenascin."
8.	Minocycline (Cyclops)FDA LinkGeneric 05/01/1997 - "In addition, the infrapatellar fat pad may be involved secondarily from extrinsic processes, including articular disorders (eg, joint effusion, intraarticular bodies, meniscal cyst, ganglion cyst, cyclops lesion), synovial abnormalities (eg, pigmented villonodular synovitis; hemophilia; synovial hemangioma; primary synovial chondromatosis; chondrosarcoma; lipoma arborescens; rheumatoid, seronegative, and septic arthritis; arthritis associated with inflammatory intestinal disorders; synovitis associated with primary osteoarthritis), and anterior extracapsular abnormalities. " 01/01/2005 - "Intraarticular masses can be classified as noninfectious synovial proliferative processes (lipoma arborescens, synovial osteochondromatosis, pigmented villonodular synovitis, rheumatoid arthritis), infectious granulomatous diseases (tuberculous arthritis, coccidioidomycosis arthritis), deposition diseases (gout, amyloid arthropathy), vascular malformations (synovial hemangioma, arteriovenous malformations), malignancies (synovial chondrosarcoma, synovial sarcoma, synovial metastases), and miscellaneous (cyclops lesion). "
9.	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 07/01/2004 - "The expression of fibroblast growth factor receptor-3 in synovial osteochondromatosis of the temporomandibular joint." 10/01/2002 - "The expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 in chondrocytes in synovial chondromatosis of the temporomandibular joint. "
10.	Calcium PyrophosphateIBA 12/01/2012 - "This report describes a very rare case of synovial chondromatosis with deposition of calcium pyrophosphate dihydrate (CPPD) crystals (pseudogout) in the temporomandibular joint (TMJ) of a 46-year-old male patient. " 12/01/2012 - "Synovial chondromatosis of the temporomandibular joint with calcium pyrophosphate dihydrate crystal deposition disease (pseudogout)." 08/01/1997 - "There were two cases of synovial chondromatosis, two of calcium pyrophosphate dihydrate crystal deposition disease, one nodular synovitis and one synovial sarcoma. "

Therapies and Procedures

1.	Activities of Daily Living (ADL) 05/01/2007 - "We report a case of synovial chondromatosis of the ankle joint, which has been successfully treated with arthroscopic removal of loose bodies and synovectomy, with the patient immediately returning to school and activities of daily living. "
2.	Arthroplasty 02/01/2013 - "This case illustrates that the diagnosis of synovial chondromatosis cannot be excluded in a patient with chronic, painful swelling of a joint, even after total joint arthroplasty." 02/01/2013 - "Total joint arthroplasty is commonly recommended as a definitive treatment for synovial chondromatosis refractory to other treatment. " 02/01/2013 - "New-onset synovial chondromatosis after total knee arthroplasty." 03/01/2010 - "To our knowledge, this is the first case of hip resurfacing arthroplasty for the definitive treatment of synovial chondromatosis. " 04/01/2008 - "Results of total hip and total knee arthroplasties in patients with synovial chondromatosis."
3.	Arthrodesis 05/01/2006 - "We describe a case of highly refractory synovial chondromatosis, which recurred despite four arthroscopic synovectomies, a chemical synovectomy, two open synovectomies and an arthrodesis. " 05/01/2006 - "Recurrent synovial chondromatosis of the knee after radical synovectomy and arthrodesis." 08/01/1998 - "Arthrodesis of the shoulder for synovial osteochondromatosis." 02/01/2009 - "Although synovial chondromatosis is typically described as a benign, self-limiting process, recurrent disease and local erosion of the joint of this patient required wide excision with bone grafting and arthrodesis for definitive treatment." 05/01/2007 - "Anterior or posterior approach may be used, and various indications have become generally accepted: anterior soft tissue or bony impingement, loose bodies, osteochondral defects, synovitis (rheumatoid arthritis, infective arthritis, and hemophilic arthropathy), posterior impingement syndrome, posttraumatic conditions, osteoarthritis (arthrosis), ankle arthrodesis, tumor-like lesions (synovial osteochondromatosis, pigmented villonodular synovitis) and many combinations of these pathological entities. "
4.	Debridement 01/01/2008 - "Following a fourteen month course of conservative management, surgical debridement of the joint revealed multiple loose bodies consistent with primary articular synovial chondromatosis. " 08/01/1990 - "Synovial chondromatosis of the shoulder treated with arthroscopic debridement and synovectomy rather than traditional open arthrotomy seems not to have been reported previously." 12/01/2002 - "In this group, osteoarthritis was noted in 21 patients, avascular necrosis of the femoral head in 16, infection of the hip joint in 3, chondrosarcoma in 2, synovial-chondromatosis in 7, acetabular labral tears in 2, and spondylitis in 3. The procedures of arthroscopy consisted of removal of loose bodies, debridement, and biopsy. "
5.	Arthroscopes 05/01/2008 - "This case report describes, for the first time, the use of interventional radiology following arthroscopy with a thin arthroscope for the diagnosis and treatment of synovial chondromatosis (SC) of the temporomandibular joint (TMJ). " 05/01/2008 - "Interventional radiology of synovial chondromatosis in the temporomandibular joint using a thin arthroscope." 03/01/2003 - "Herein we report on 2 cases of synovial chondromatosis of the hip, which were managed with an arthroscope-assisted synovectomy and removal of the loose bodies. " 03/01/2003 - "Synovial chondromatosis of the hip: management with arthroscope-assisted synovectomy and removal of loose bodies: report of two cases."