Cadherins (E-Cadherin)

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

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Networked: 6849 relevant articles (102 outcomes, 1095 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seruca, Raquel: 49 articles (10/2015 - 05/2002)
2.	Oliveira, Carla: 31 articles (04/2015 - 05/2002)
3.	Paredes, Joana: 28 articles (01/2015 - 01/2002)
4.	Hirohashi, Setsuo: 26 articles (04/2011 - 01/2002)
5.	Höfler, Heinz: 24 articles (05/2012 - 06/2002)
6.	Becker, Karl-Friedrich: 23 articles (01/2013 - 06/2002)
7.	Schmitt, Fernando: 22 articles (08/2014 - 01/2002)
8.	Carneiro, Fátima: 19 articles (10/2015 - 03/2003)
9.	Zhang, Wei: 18 articles (01/2016 - 04/2005)
10.	Luber, Birgit: 18 articles (01/2015 - 06/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "While the numbers were small and conclusions should be viewed with caution, negative/low E-cadherin expression was associated with improved PFS and OS for hepatobiliary cancers (most significant in HCC) in this refractory patient population where we expected lower expression levels. " 01/01/1997 - "The lost or heterogeneous expression of E-cadherin in tumor tissue was also significantly associated with an increased incidence of tumor recurrence after apparently curative resection, a reduced overall survival rate, and a reduced disease-free patient survival rate. " 10/21/2002 - "Furthermore, absence of either CD103 from the T cells or E-cadherin expression from the cancer cells resulted in a significant reduction in cancer cell lysis. " 10/14/1994 - "A significant reduction in DXR accumulation and cytotoxicity was observed in NM-f-ras-TD-CAMx, which expresses E-cadherin, suggesting that E-cadherin could play a role in the increase of drug resistance observed in confluent cancer cells." 08/01/2013 - "When differentiating the origin of a tumor as either esophageal or pulmonary, an immunohistochemical panel consisting of IMP3, CDX2, and N-cadherin is superior to either TTF-1 or napsin A."
2.	Neoplasm Metastasis (Metastasis) 06/01/2005 - "Strong E-cadherin expression in lymph node metastases was highly predictive of improved survival. " 01/01/2013 - "Furthermore, SFN treatment resulted in a significant reduction in EMT markers Zeb-1, which correlated with increase in E-Cadherin expression suggesting the blockade of signaling involved in early metastasis. " 06/01/2005 - "A scattergram was generated which identified a subset of patients (25%) with high E-cadherin expression in nodal metastases, and this top quartile had improved survival (P = 0.028). " 06/01/2005 - "On univariate analysis, reduced E-cadherin expression was associated with a reduced disease-free interval and overall survival and also with indicators of poor prognosis including larger tumour size, higher histological grade, development of distant metastasis and tumours negative for oestrogen receptors. " 01/01/2001 - "Therefore, examination of the expression of E-cadherin and Y-K's mode of invasion would be helpful in predicting lymph node metastasis in esophageal SCC."
3.	Carcinoma (Carcinomatosis) 10/01/2009 - "DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin." 12/01/2015 - "The Minimal Carcinoma (MC) Triple Stain is a tri-chromogen multiplex immunostain (CK7, p63, and E-cadherin) helpful in classifying morphologically ambiguous and/or small carcinomas as either ductal or lobular and/or in situ or invasive. " 10/01/2015 - "The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous gland carcinoma (SGC) and to correlate with clinicopathological high-risk features. " 07/01/2014 - "The study revealed that the positive PRL-3 expression and abnormal E-cadherin expression were associated with mucinous gastric carcinoma and lymph node involvement. " 03/01/2014 - "The aim of this study is to examine the expression of β-catenin, APC and E-cadherin in tumour tissues of 80 Tunisian patients with gastric carcinoma and to determine the methylation status of the APC promoter in tumour tissues. "
4.	Breast Neoplasms (Breast Cancer) 12/07/2010 - "the findings support the evidence that high expression values of E-cadherin are not predictive for a good prognosis and may help to explain conflicting evidence on the prognostic impact of E-cadherin in breast cancer when assessed on dichotomic basis." 11/01/2007 - "A progressive and statistically significant reduction of E-cadherin expression was detected in the histologically well- to moderately to poorly differentiated breast cancer cells (p < 0.001). " 05/01/2011 - "E-cadherin immunohistochemistry is helpful in classifying breast cancer cases with indeterminate histopathologic features. " 08/28/2015 - "In the present study, ERα upregulated the expression of the epithelial marker, E-cadherin, in breast cancer cells through the transcriptional down-regulation of Bmi1. " 06/01/2015 - "This study confirmed that FOXA2 inhibited EMT in breast cancer cells by regulating the transcription of EMT-related genes such as E-cadherin and ZEB2. "
5.	Adenocarcinoma 11/01/2005 - "The tumoral expression of c-erbB-2 and E-cadherin did not demonstrate a correlation with the staging and degree of cell differentiation, and it did not present prognostic value regarding disease recurrence, disease-free interval, survival and specific mortality among patients with colorectal adenocarcinoma." 09/01/2014 - "We here report the first study to investigate the expression of epithelial-mesenchymal transition (EMT) markers Snail1 and E-cadherin in GEJ adenocarcinoma. " 11/01/2013 - "Recent studies have demonstrated that partial or complete loss of E-cadherin (EC) and nuclear accumulation of zeste homolog 2 (EZH2) are hallmarks of poorly differentiated pancreatic adenocarcinoma (PAC). " 08/01/2013 - "In this study, 24 cases each of pulmonary and esophageal adenocarcinomas were stained with TTF-1, napsin A, CDX2, 34βE12, N-cadherin, and IMP3 in an attempt to define an optimal panel for differentiation. " 03/01/2013 - "In this study, we evaluated the prevalence of abnormal E-cadherin expression in Iranian patients with gastric adenocarcinoma, and tried to find its correlation with H. "

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	beta Catenin
3.	Messenger RNA (mRNA)
4.	Vimentin
5.	Biological Markers (Surrogate Marker)
6.	Estrogens (Estrogen)
7.	Fibronectins (Fibronectin)
8.	Antigens
9.	Syndecan-1 (Syndecan 1)
10.	Collagenases (Collagenase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplantation (Transplant Recipients)
4.	Gastrectomy
5.	Radioimmunotherapy